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| 1 | Trefoil factors:Tumor progression markers and mitogens via EGFR/MAPK activation in cholangiocarcinoma显示文摘AIM:To investigate trefoil factor(TFF) gene copy number,mRNA and protein expression as potential biomarkers in cholangiocarcinoma(CCA).METHODS:TFF mRNA levels,gene copy number and protein expression were determined respectively by quantitative reverse transcription polymerase chain reaction(PCR),quantitative PCR and immunohistochemistry in bile duct epithelium biopsies collected from individuals with CCA,precancerous bile duct dysplasia and from disease-free controls.The functional impact of recombinant human(rh) TFF2 peptide treatment on proliferation and epidermal growth factor receptor(EGFR) /mitogenactivated protein kinase(MAPK) signaling was assessed in the CCA cell line,KMBC,by viable cell counting and immunoblotting,respectively.RESULTS:TFF1,TFF2 and TFF3 mRNA expression was significantly increased in CCA tissue compared to disease-free controls,and was unrelated to gene copy number.TFF1 immunoreactivity was strongly increased in both dysplasia and CCA,whereas TFF2 immunoreactivity was increased only in CCA compared to diseasefree controls.By contrast,TFF3 immunoreactivity was moderately decreased in dysplasia and further decreased in CCA.Kaplan-Meier analysis found no association of TFF mRNA,protein and copy number with age,gender,histological subtype,and patient survival time.Treatment of KMBC cells with rhTFF2 stimulated proliferation,triggered phosphorylation of EGFR and downstream extracellular signal related kinase(ERK),whereas co-incubation with the EGFR tyrosine kinase inhibitor,PD153035,blocked rhTFF2-dependent proliferation and EGFR/ERK responses.CONCLUSION:TFF mRNA/protein expression is indicative of CCA tumor progression,but not predictive for histological sub-type or survival time.TFF2 is mitogenic in CCA via EGFR/MAPK activation. | Kanuengnuch Kosriwong Trevelyan R Menheniott Andrew S Giraud Patcharee Jearanaikoon Banchob Sripa Temduang Limpaiboon | 2011 | World Journal of Gastroenterology2011，17，12： | 16 |
| 2 | Targeting STAT3 in gastric cancer显示文摘 | Andrew S Giraud Trevelyan R Menheniott Louise M Judd | 2012 | Expert Opinion on Therapeutic Targets2012，，9： | 3 |
| 3 | A novel Gastrokine,Gkn3,marks gastric atrophy and shows evidence of adaptive gene loss in humans显示文摘 | Menheniott TR Peterson AJ O'Connor L | 2010 | Gastroenterology2010，138，5： | 1 |
| 4 | Cytokine signalling via gpl30 in gastric cancer显示文摘 | Howlett M Menheniott T R Judd L M | 2009 | Biochim Bio- phy Acta2009，1793，11： | 1 |
| 5 | lnhibition of gastric carcinogenesis by the hormone gastrin is mediated by sup-pression of TFF1 epigenetic silencing显示文摘 | Tomita H Takaishi S Menheniott TR | 2011 | Gastroenterology2011，140，3： | 1 |
| 6 | Helicobaeter pylnri infect- ion promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and 0 humans显示文摘 | Peterson A J Menheniott T R O Connor L | 2010 | Gastroenterology2010，139，6： | 1 |
| 7 | Gastrokines: stomach-specific proteins with putative homeostatic and tumor suppressor roles显示文摘 | Menheniott TR Kurklu B Giraud AS | 2013 | Am J Physiol Gastrointest Liver Physiol2013，304，2： | 1 |
| 8 | Gastrokines: stom- ach-specific proteins with putative homeostatic and tumor suppressor roles 显示文摘 | Menheniott T R Kurklu B Giraud A S | 2013 | Am J Physiol Gastrointest LiverPhysiol2013，304，2： | 1 |
| 9 | A novel gastrokine, C, kn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans 显示文摘 | Menheniott TR Peterson AJ O'Connor L | 2010 | Gastroenterology2010，138，5： | 1 |
| 10 | An enhancer element at the Igf2/ H19 locus drives gene expression in both imprinted and non-imprinted tissues显示文摘 | Charalambous M Menheniott T R Bennett W R Bennett W R Kelly S M Dell G | 2004 | Dev Biol2004，271，： | 1 |
| 11 | An enhancer element at the Igf2/H19 locus drives gene expression in both imprinted and non - imprinted tissues 显示文摘 | Charalambous M Menheniott TR Bennett WR | 2004 | Dev Biol2004，271，2： | 1 |
| 12 | Targeting STAT3 in gas- tric caneer显示文摘 | Giraud A S Menheniott T R Judd L M | 2012 | Expert Opin Ther Targets2012，16，9： | 1 |
| 13 | Targeting STAT3 in gastric cancer 显示文摘 | Giraud AS Menheniott TR Judd LM | 2012 | Expert Opin Ther Targets2012，16，9： | 1 |
| 14 | Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo显示文摘 | Judd LM Menheniott TR Ling H | 2014 | PLo S One2014，9，95： | 1 |
| 15 | An enhance relement at the Igf2/H19 locus drives gene expressionin both imprinted and non-imprinted tissues显示文摘 | CHARALAMBOUS M MENHENIOTT T R BENNETT W R | 2004 | Dev Biol2004，271，2： | 1 |
| 16 | Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo 显示文摘 | Judd LM Menheniott TR Ling H | 2014 | PLoS One2014，9，95： | 1 |
| 17 | An enhancer element at the Igf 2/H19 locus drives gene expression in both imprinted and non-imprinted tissues显示文摘 | Charalambous M Menheniott TR Bennett WR | 2004 | Dev Biol2004，271，2： | 1 |
| 18 | An enhancer element at the Igf2/H19 locus drives gene expression in both imprinted and non-imprinted tissues显示文摘 | Charalambous M Menheniott TR Bennett WR | 2004 | Dev Biol2004，271，： | 1 |
| 19 | An enhancer element at the igf2/h19 locus drives gene expression in both imprinted and non-imprinted tissues显示文摘 | Charalambous M Menheniott T R Bennett W R | | 0，，2： | 1 |
| 20 | Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing 显示文摘 | Tomita H Takaishi S Menheniott TR | 2011 | Gastroenterology2011，140，： | 1 |
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