|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 2 | MIKC-type MADS- domain proteins: Structural modularity, protein interac- tions and network evolution in land plants 显示文摘 | Kaufmann K Melzer R Theissen G | 2005 | Gene2005，347，： | 1 |
| 3 | Ethylcellulose:a new type of emul-sion stabilizer显示文摘 | Melzer E Kreuter J Daniels R | 2003 | European Journal of Pharmaceutics and Biopharmaceutics2003，56，1： | 1 |
| 4 | MIKC-type MADS domain proteins: structural modularity, protein interactions and net- work evolution in land plants显示文摘 | Kaufmann K Melzer R Theil3en G | 2005 | Gene2005，347，2： | 1 |
| 5 | Srcrole synthase activity does not restrict glycolysis in roots of transgenic potato plants under hypoxic conditions显示文摘 | BIEMELT S HAJIREZAEI M R MELZER M | 1999 | Planta1999，210，1： | 1 |
| 6 | The naked and the dead : the ABCs of gymnosperm reproduction and the or- igin of the angiosperm flower 显示文摘 | Melzer R Wang Y Q Theissen G | 2010 | Semin Cell Dev Biol2010，21，1： | 1 |
| 7 | Ethylcellulose : a new type of emulsion stabilizer 显示文摘 | Melzer E Kreuter J Daniels R | 2003 | European Journal of Pharma- ceutics and Biopharmaceuties2003，56，1： | 1 |
| 8 | Preliminary data of a HAMD - 17 validated symptom scale derived from the ICD - 10 to diagnose depres- sion in outpatients显示文摘 | Melzer J Rostock M Brignoli R eta/ | 2012 | Forsch Komplement treed2012，19，： | 1 |
| 9 | A light-and temperatureentrained circadian clock controls expression of transcripts encoding nuclear proteins with homology to RNA-binding proteins in meristematic tissue 显示文摘 | Heintzen C Melzer S Fischer R | 1994 | Plant J1994，5，： | 1 |
| 10 | MIKC-type MADS-domain proteins:structural modularity,protein interactions and network evolution in land plants 显示文摘 | KAUFMANN K MELZER R THEISSEN G | 2005 | Gene2005，347，2： | 1 |
| 11 | MIKC-type MADS-domain proteins: structural modularity, protein inter- actions and network evolution in land plants 显示文摘 | KAUFMANN K MELZER R THEI~EN G | 2005 | Gene2005，347，2： | 1 |
| 12 | Grey matter atrophy in cognitively impaired Parkinson's disease 显示文摘 | Melzer TR Watts R MacAskill MR | 2012 | J Neurol Neu- rosurg Psychiatry2012，83，2： | 1 |
| 13 | Clinical studies on the efficacyand safety of padma 28,a complex herbal formulation from Tibet-an medicine: an overview显示文摘 | Vennos C Melzer J Sailer R | 2013 | Forsch Komplementarmed2013，20，2： | 1 |
| 14 | A combined system of lagoon and constructed wetland for an effective wastewater treatment显示文摘 | Weinhart S Melzer A | 2003 | Water Res2003，37，： | 1 |
| 15 | White matter microstructure deteriorates across cognitive stages in Parkinson disease显示文摘 | Melzer TR Watts R Macaskill MR | 2013 | Neurology2013，80，： | 1 |
| 16 | Srcrole synthase activity does not restrict glycolysis in roots of transgenic potato plants under hypoxia conditions显示文摘 | BIEMELT S HAJIREZAEI M R MELZER M | 1999 | Planta1999，210，1： | 1 |
| 17 | Preliminary data of a HAMD - 17 validated symptom scale derived from the ICD - 10 to diagaxose depression in outpatients 显示文摘 | Melzer J Rostock M Brignoli R | 2012 | Forschende Komple- ment ? rmedizin/Research in Complementary Medicine2012，19，4： | 1 |
| 18 | MIKC-type MADS-do- main proteins : structural modularity, protein interactions and network evolution in land plants 显示文摘 | Kaufmann K Melzer R Theissen G | 2005 | Genes2005，347，： | 1 |
| 19 | The naked and the dead: the ABCs of gymnosperm reproduction and the origin of the angiosperm flower 显示文摘 | MELZER R WANG Y Q THEISSEN G | 2010 | Semin Cell Dev Biol2010，21，1： | 1 |
| 20 | The p21-aetivated kinase Mbt is a component of the apical protein complex in central brain neuroblasts and controls cell proliferation显示文摘 | Melzer J1 Kraft KF Urbaeh R | 2013 | Development2013，140，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员