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| 1 | Neuroimaging the brain-gut axis in patients with irritable bowel syndrome显示文摘AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. | Kristen R Weaver Lee Anne B Sherwin Brian Walitt Gail D'Eramo Melkus Wendy A Henderson | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 8 |
| 2 | The effect of a diabetes education,coping skills training,and care intervention on physiological and psychoogcial outcomes in black women with type 2 diabetes显示文摘 | DEramo Melkus G Chyun D Vordestrasse A | 2010 | Biological Research For Nursing2010，12，1： | 1 |
| 3 | Diffusion-tensor imaging of hu- man articular cartilage specimens with early signs of cartilage dam- age 显示文摘 | Jos6 GR Melkus G Silvia AN | 2013 | Radiolo~2013，266，： | 1 |
| 4 | Scheduled and unscheduled hospital readmissions among diabetes patients显示文摘 | Kim H Ross JS Melkus GD | 2010 | Am J Manag Care2010，16，10： | 1 |
| 5 | MRI quantification of fatty infiltration and muscle atrophy in a mouse model of rotator cuff tears显示文摘 | Samagh SP Kramer EJ Melkus G | 2013 | J Orthop Res2013，31，3： | 1 |
| 6 | Diffusion-tensor ima- ging of human articular cartilage specimens with early signs of car- tilage damage显示文摘 | Raya J G Melkus G Adam-Neumair S | 2013 | Radiology2013，266，3： | 1 |
| 7 | Change of diffusion tensor imaging parameters in articular cartilage with progressive proteoglycan extraction显示文摘 | Raya J G Melkus G Adam-Neumair S | 2011 | lnwest Radiol2011，46，6： | 1 |
| 8 | The association of psychological factors,physical activity,neuropathy,and quality of life in type 2 diabetes显示文摘 | Chyun DA Melkus GD Katten DM | | 0，，04： | 1 |
| 9 | Reducing the risks ofdiabetes complications through diabetes self-management educationand support显示文摘 | Kent D D’Eramo Melkus G Stuart PM | 2013 | PopuI Health Manag2013，16，2： | 1 |
| 10 | Change of diffusion tensor imaging parameters in articular cartilage with progressive proteoglycan extraction显示文摘 | Raya JG Melkus G Adam-Neumair S | | 0，，6： | 1 |
| 11 | Diffusion-tensor imaging of human articular cartilage specimens with early signs of cartilage damage显示文摘 | Raya JG Melkus G Adam-Neumair S | | 0，，3： | 1 |
| 12 | The effect of a diabetes education, coping skills training, and care intervention on physiological and psychosocial outcomes in black women with type 2 diabetes显示文摘 | D'Eramo Melkus G Chyun D Vorderstrasse A | 2010 | Biol Res Nuts2010，12，1： | 1 |
| 13 | The Effect of a DiabetesEducation,Coping Skills Training,and Care Intervention onPhysiological and Psychosocial Outcomes in Black Women WithType 2 Diabetes显示文摘 | Melkus GD Chyun D Vorderstrasse A | 2010 | Biol Res Nurs2010，12，1： | 1 |
| 14 | Diffusion tensor imaging and T2 relaxometry of bilateral lumbar nerve roots: feasibility of in-plane imaging 显示文摘 | Karampinos DC Melkus G Shepherd TM | 2013 | NMR Biomed2013，26，6： | 1 |
| 15 | An Experimental Study of Heat of Immersion o Coal显示文摘 | Melkus T G Chiang S H | 1987 | Colloids and Surfaces1987，28，： | 1 |
| 16 | Diffusion tensor im- aging and T2 relaxometry of bilateral lumbar nerve roots: feasibility of in-plane imaging显示文摘 | Karampinos DC Melkus G Shepherd TM | 2013 | NMR Biomed2013，26，6： | 1 |
| 17 | Bio- logical effects of T315I-mutated BCR-ABL in an embry- onic stem cell--derived hematopoiesis model 显示文摘 | Melkus M Bennaceur-Griscelli A Valogne Y | 2013 | Exp Hema- tol2013，41，4： | 1 |
| 18 | Reducing the risks of diabetes complications through diabetes self- man- agement education and support 显示文摘 | Kent D D'Eramo Melkus G Stuart PM | 2013 | Popul Health Manag2013，16，2： | 1 |
| 19 | The association of psychological factors,physical activity,neuropathy,and quality of life in type 2 diabetes显示文摘 | Chyun DA Melkus GD Katten DM | 2006 | Biol Res Nurs2006，7，4： | 1 |
| 20 | Barriers to medical nutrition therapy in black women with type 2 diabetes mellitus显示文摘 | Galasso P Amend A Melkus GD | 2005 | Diabetes Educ2005，31，5： | 1 |
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