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| 1 | Role of systemic inflammation in cirrhosis:From pathogenesis to prognosis显示文摘The natural history of cirrhosis can be divided into an initial stage, known as compensated cirrhosis, and an advanced stage which encompasses both decompensated cirrhosis and acute-on-chronic liver failure(ACLF). The latter syndrome has been recently described as an acute deterioration of liver function in patients with cirrhosis, which is usually triggered by a precipitating event and results in the failure of one or more organs and high short-term mortality rates. Each stage is characterized by distinctive clinical manifestations and prognoses. One of the key elements involved in cirrhosis physiopathology is systemic inflammation, recently described as one of the components in the cirrhosis-associated immune dysfunction syndrome. This syndrome refers to the combination of immune deficiency and exacerbated inflammation that coexist during the course of cirrhosis and relates to the appearance of clinical complications. Since systemic inflammation is often difficult to assess in cirrhosis patients, new objective, reproducible and readily-available markers are needed in order to optimize prognosis and lengthen survival. Thus, surrogate serum markers and clinical parameters of systemic inflammation have been sought to improve disease follow-up and management, especially in decompensated cirrhosis and ACLF. Leukocyte counts(evaluated as total leukocytes, total eosinophils or neutrophil:lymphocyte ratio) and plasma levels of procalcitonin or C-reactive protein have been proposed as prognostic markers, each with advantages and shortcomings. Research and prospective randomized studies that validate these and other markers are clearly warranted. | Melisa Dirchwolf Andres Eduardo Ruf | 2015 | World Journal of Hepatology2015，7，16： | 18 |
| 2 | Management of hepatitis B reactivation in immunosuppressed patients: An update on current recommendations显示文摘The proportion of hepatitis B virus(HBV) previously exposed patients who receive immunosuppressive treatment is usually very small. However, if these individuals are exposed to potent immunosuppressive compounds, the risk of HBV reactivation(HBVr) increases with the presence of hepatitis B surface antigen(HBsAg) in the serum. Chronic HBsAg carriers have a higher risk than those who have a total IgG anticore as the only marker of resolved/occult HBV disease. The loss of immune control in these patients may results in the reactivation of HBV replication within hepatocytes. Upon reconstitution of the immune system, infected hepatocytes are once again targeted and damaged by immune surveillance in an effort to clear the virus. There are different virological scenarios, and a wide spectrum of associated drugs with specific and stratified risk for the development of HBVr. Some of this agents can trigger a severe degree of hepatocellular damage, including hepatitis, acute liver failure, and even death despite employment of effective antiviral therapies. Currently, HBVr incidence seems to be increasing around the world; a fact mainly related to the incessant appearance of more powerful immunosuppressive drugs launched to the market. Moreover, there is no consensus on the length of prophylactic treatment before the patients are treated with immunosuppressive therapy, and for how long this therapy should be extended once treatment is completed. Therefore, this review article will focus on when to treat, when to monitor, what patients should receive HBV therapy, and what drugs should be selected for each scenario. Lastly, we will update the definition, risk factors, screening, and treatment recommendations based on both current and different HBV management guidelines. | Fernando Bessone Melisa Dirchwolf | 2016 | World Journal of Hepatology2016，8，8： | 10 |
| 3 | Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis显示文摘The nonalcoholic fatty liver disease(NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD encompasses a wide histological spectrum ranging from benign simple steatosis to non-alcoholic steatohepatitis(NASH). Sustained inflammation in the liver is critical in this process. Hepatic macrophages, including liver resident macropaghes(Kupffer cells), monocytes infiltrating the injured liver, as well as specific lymphocytes subsets play a pivotal role in the initiation and perpetuation of the inflammatory response, with a major deleterious impact on the progression of fatty liver to fibrosis. During the last years, Th17 cells have been involved in the development of inflammation not only in liver but also in other organs, such as adipose tissue or lung. Differentiation of a na?ve T cell into a Th17 cell leads to pro-inflammatory cytokine and chemokine production with subsequent myeloid cell recruitment to the inflamed tissue. Th17 response can be mitigated by T regulatory cells that secrete anti-inflammatory cytokines. Both T cell subsets need TGF-β for their differentiation and a characteristic plasticity in their phenotype may render them new therapeutic targets. In this review, we discuss the role of the Th17 pathway in NAFLD progression to NASH and to liver fibrosis analyzing different animal models of liver injury and human studies. | Carla Melisa Chackelevicius Sabrina Eliana Gambaro Claudio Tiribelli Natalia Rosso | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 4 | 医院家长式领导对医护人员离职意愿影响机制的跨层次研究显示文摘家长式领导深刻影响着东方文化情境下的组织与员工。本文基于资源保存理论视角,通过两个不同文化情境下的子研究,采用多层次结构方程模型分析,建构并检验了医院科室家长式领导对员工离职意愿的跨层次影响机制,表明了工作-家庭文化、情绪疲惫以及幸福感的中介作用。研究成果拓展了领导方式、组织文化、个人情绪特征之间关系的理论认识,为医院留住与激励医护人员提供借鉴。 | 赵新元 王甲乐 Melisa Santjoko 林彩虹 | 2020 | 管理评论2020，32，9： | 4 |
| 5 | Medical management of metabolic and cardiovascular complications after liver transplantation显示文摘Liver transplantation represents the only curative option for patients with endstage liver disease,fulminant hepatitis and advanced hepatocellular carcinoma.Even though major advances in transplantation in the last decades have achieved excellent survival rates in the early post-transplantation period,long-term survival is hampered by the lack of improvement in survival in the late post transplantation period(over 5 years after transplantation).The main etiologies for late mortality are malignancies and cardiovascular complications.The latter are increasingly prevalent in liver transplant recipients due to the development or worsening of metabolic syndrome and all its components(arterial hypertension,dyslipidemia,obesity,renal injury,etc.).These comorbidities result from a combination of pre-liver transplant features,immunosuppressive agent side-effects,changes in metabolism and hemodynamics after liver transplantation and the adoption of a sedentary lifestyle.In this review we describe the most prevalent metabolic and cardiovascular complications present after liver transplantation,as well as proposing management strategies. | Chiara Becchetti Melisa Dirchwolf Vanessa Banz Jean-Francois Dufour | 2020 | World Journal of Gastroenterology2020，26，18： | 4 |
| 6 | The microbial content of unexpired pasteurized milk from selected supermarkets in a developing country显示文摘Objective:To determine the presence and levels of microbes in unexpired pasteurized milk from randomly selected supermarkets in Kingston,Jamaica.Methods:The quantitative study used a stratified random sampling technique in the selection of the 20 representative milk samples from six(6) supermarkets.Microbiological tests such as methylene blue reduction,standard plate count(SPC),coliform plate count(CPC),purity plate culture,gram staining and biochemical tests were performed to examine the microbes in purchased unexpired pasteurized milk.Results:One sample(BCr016) had a pH of 4.0.a rancid odour and curdled appearance.It decolourized within one hour during the methylene blue reduction test and was classified as class 4 milk.Seven of the samples were sterile with no microbe growth on the plate count agar and violet red bile salt agar(VRBA).The milk samples that appeared to be safe for consumption were all 10,11,12 and 13 days before expiration.The VRBA sample BCr016,had a colony count of 13 400 CFU/ mL.There was the presence of Escherichia coli in sample LCr021 which had a standard plate count of 1 580 SPC/mL and a coliform count of 500 CFU/mL.Enterobacter sp.was present in colonies from BCr016 and all the other milk samples.Conclusions:Unacceptable levels of Entembacter spp.and Escherichia coli were found in most of the samples.Effective measures to ensure safe milk for human consumption such as the phosphatase test and methylene blue reduction test should be routinely performed on each batch of milk processed by dairy plants. | Melisa Anderson Patrice Hinds Stacyann Hurditt Princena Miller Donovan McGrowder Ruby Alexander-Lindo | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 3 |
| 7 | 老年癌症患者的免疫治疗显示文摘癌症常见于老年人。初诊为恶性肿瘤的患者的中位年龄为66岁,癌症相关死亡的中位年龄为72岁[1]。老年人是癌症患病率增长最快的人群之一[2]。免疫治疗的发展,尤其是免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)的问世,彻底改变了所有年龄层包括老年人在内的肿瘤患者的常规治疗方案。细胞毒性T淋巴细胞相关抗原4、程序性死亡受体1(programmed death receptor-1,PD-1)及其配体(programmed death-ligand 1,PD-L1)的抑制剂可改善多种肿瘤患者的总生存期(overall survival,OS)[3],且部分患者可获得持续缓解[4]。 | Carolyn J.PRESLEY Fabio GOMES Christin E.BURD Ravindran KANESVARAN Melisa L.WONG 李昕(翻译) 陈军(校对) | 2021 | 中国肺癌杂志2021，24，10： | 2 |
| 8 | Attitudes toward marriage and p remaritalsexual activity of college freshmen显示文摘 | Salts Connie J Seismore Melisa D L indholm Byron W Smith&Thomas | | 0，，116： | 1 |
| 9 | Spatial and temporal variability in forest growth in the Olympic Mountains, Washington:sensitivity to climatic variability 显示文摘 | Melisa L H David L P | 2006 | Can J For Res2006，36，1： | 1 |
| 10 | Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β1 subunit显示文摘 | Pedro MARTIN Melisa MONCADA Guruprasad KUNTAMALLAPPANAVAR Alex M DOPICO Veronica MILESI | 2018 | Acta Pharmacologica Sinica2018，39，3： | 1 |
| 11 | Long-Term Propagation of Distinct Hematopoietic Differentiation Programs In Vivo显示文摘 | Brad Dykstra David Kent Michelle Bowie Lindsay McCaffrey Melisa Hamilton Kristin Lyons Shang-Jung Lee Ryan Brinkman Connie Eaves | 2007 | Cell Stem Cell2007，，2： | 1 |
| 12 | Mycoplasma pneumoniae Protein P30 Is Required for Cytadherence and Associated with Proper Cell Development显示文摘 | Cynthia E Susan J Melisa J | 1999 | Journal of Bacteriology1999，181，4： | 1 |
| 13 | Correlation between Waardenburg syndrome phenotype and genotype in a population of individuals with identified PAX3 mutations显示文摘 | Anita L. DeStefano L. Adrienne Cupples Kathleen S. Arnos J. H. Jr. Asher Clinton T. Baldwin Susan Blanton Melisa L. Carey Elias O. da Silva T. B. Friedman Jacquie Greenberg Anil K. Lalwani Aubrey Milunsky Walter E. Nance Arti Pandya Rajkumar S. Ramesar An | 1998 | Human Genetics1998，，5： | 1 |
| 14 | Immunogenicity of a new purified fusion protein vaccine to respiratory syncytial virus: a multi-center trial in children with cystic fibrosis显示文摘 | Pedro A. Piedra Stanley G. Cron Alan Jewell Nicole Hamblett Ruth McBride Melisa A. Palacio Richard Ginsberg Christopher M. Oermann Peter W. Hiatt | 2003 | Vaccine2003，，19： | 1 |
| 15 | Social inequality in Pap smear coverage:identifying under-users of cervical cancer screening in Argentina显示文摘 | Silvina A Silvina R Melisa P | 2008 | Reprod Health Matters2008，16，32： | 1 |
| 16 | Medical tourism: A review of the literature and analy- sis of a role for bi-lateral trade显示文摘 | Richard Melisa Martinez ?lvarez Rupa Chanda | 2011 | Health Policy2011，，103： | 1 |
| 17 | Ficus carica L. (Moraceae): An ancient source of food and health显示文摘 | Melisa I. Barolo Nathalie Ruiz Mostacero Silvia N. López | 2014 | Food Chemistry2014，，： | 1 |
| 18 | Spatial and temporal variability in forest growth in the Olympic Mountains, Washington: sensitivity to cli- matic variability 显示文摘 | Melisa L H David L P | 2006 | Canadian Journal of Forest Research2006，36，1： | 1 |
| 19 | Lottery‑like preferences and the MAX effect in the cryptocurrency market显示文摘We investigate the significance of extreme positive returns in the cross-sectional pricing of cryptocurrencies.Through portfolio-level analyses and weekly cross-sectional regressions on all cryptocurrencies in our sample period,we provide evidence for a positive and statistically significant relationship between the maximum daily return within the previous month(MAX)and the expected returns on cryptocurrencies.In particular,the univariate portfolio analysis shows that weekly average raw and riskadjusted return differences between portfolios of cryptocurrencies with the highest and lowest MAX deciles are 3.03%and 1.99%,respectively.The results are robust with respect to the differences in size,price,momentum,short-term reversal,liquidity,volatility,skewness,and investor sentiment. | Melisa Ozdamar Levent Akdeniz Ahmet Sensoy | 2021 | Financial Innovation2021，7，1： | 1 |
| 20 | 汉语与西班牙语中动物词汇象征意义的对比研究显示文摘汉语和西班牙语中有大量与动物有关的词汇。由于语言与文化关系密切,动物词汇除了本身具有的字面意义外,还承载着丰富的文化内涵。对比汉语和西班牙语中的动物词汇发现,一些动物词汇在两种不同文化中具有相同或类似的象征意义;一些动物词汇在两种文化中具有不同的象征意义;还有一些动物词汇在一种文化中具有象征意义而在另一种文化中没有任何象征意义。探究动物词汇象征意义异同背后的原因,有助于更好地了解中国和母语为西班牙语的秘鲁两国文化,促进跨文化交际,提高对外汉语教学的效果。 | Melisa Barrueto Castillo 潘飞 | 2021 | 浙江科技学院学报2021，33，4： | 1 |
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