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| 1 | Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks显示文摘Avian infectious bronchitis virus(IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopathological lesions were observed in the tracheal mucosa at 3–5days post inoculation(dpi) and in the kidney at 8 dpi, with heavy viral loads at 1–11 and 1–28 dpi,respectively. The expression of m RNAs encoding Toll-like receptor(TLR) 3 and TLR7 were upregulated at 3–8 dpi, and that of TIR-domain-containing adapter-inducing interferon(IFN) β(TRIF) was upregulated at 21 dpi in the trachea and kidney. Myeloid differentiation primary response protein 88(My D88) was upregulated in the trachea during early infection. Tumor necrosis factor receptor-associated factor(TRAF) 3 and TRAF6 were upregulated expression in both tissues.Moreover, melanoma differentiation-associated protein 5(MDA5), laboratory of genetics and physiology 2(LGP2), stimulator of IFN genes(STING), and mitochondrial antiviral signaling protein(MAVS), as well as TANK binding kinase 1(TBK1), inhibitor of kappa B kinase(IKK) ?, IKKα, IKKβ,IFN regulatory factor(IRF) 7, nuclear factor of kappa B(NF-κB), IFN-α, IFN-β, various interleukins(ILs), and macrophage inflammatory protein-1β(MIP-1β) were significantly upregulated in the trachea and downregulated in the kidney. These results suggested that the TLR and MDA5 signaling pathways and innate immune cytokine were induced after IBV infection. Additionally,consistent responses to IBV infection were observed during early infection, with differential and complicated responses in the kidney. | Yining He Zhiwen Xie Jinglong Dai Yanjie Cao Jinlian Hou Yansheng Zheng Tianchao Wei Meilan Mo Ping Wei | 2016 | Virologica Sinica2016，31，1： | 14 |
| 2 | Protective effects of a new metalloporphyrin on paraquat-induced oxidative stress and apoptosis in N27 cells显示文摘Paraquat (PQ, 1,1'-dimethyl-4,4'-bipyridinium ) ,使用得广泛地的除草剂,为 Parkinson 的疾病的发展作为一个潜在的 etiologic 因素被建议了。在最近的年里,许多研究集中于 PQ neurotoxicity 的机制。在这研究,我们检验了锰( III )的 neuroprotective 效果 meso-tetrakis ( N , N'-diethylimidazolium )卟啉( MnTDM ),超级氧化物 dismutase/catalase 模仿,在在 1RB ( 3 )的 导致PQ 的氧化应力和 apoptosis 上一( 27 )( N27 )房间,一根 dopaminergic neuronal 房间线。结果显示 MnTDM 显著地稀释了房间生存能力,谷胱甘肽弄空,和反应的氧种类生产的导致 PQ 的损失。MnTDM 也改善了 apoptosis 的导致 PQ 的词法原子变化和 apoptosis 的增加的率。另外,我们的数据提供 MnTDM 压制了导致 PQ 的 caspase-3 劈开的直接证据,可能 PQ neurotoxicity 的一个关键事件。这些观察建议了那个氧化压力, apoptosis 在导致 PQ 的 neurotoxicity 被含有,这毒性能被 MnTDM 阻止。这些调查结果也为 Parkinson 与氧化应力联系的疾病和另外的混乱建议了一条新奇治疗学的途径。 | Ping Chen Ang Li Mengjie Zhang Meilan He Zhen Chen Xiaokang Wu Chunjun Zhao Shilong Wang Liping Liang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，2： | 4 |
| 3 | Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury显示文摘 | Guofang Xue Meilan He Jie Zhao Yan Chen Yun Tian Baozhen Zhao Bo Niu | 2011 | Regenerative medicine2011，6，6： | 1 |
| 4 | Comprehensive Analysis of Peripheral Blood Lymphocytes in 76 Women with Recurrent Miscarriage before and after Lymphocyte Immunotherapy显示文摘 | Peiyan Liang Meilan Mo Guan‐Gui Li Biao Yin Jing Cai Tonghua Wu Xuebing He Xu Zhang Yong Zeng | 2012 | Am J Reprod Immunol2012，，2： | 1 |
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