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| 1 | Blown sand motion within the sand-control system in the southern section of the Taklimakan Desert Highway显示文摘Although scientists have performed many studies in the Taklimakan Desert, few of them have reported the blown sand motion along the southern edge of the Taklimakan Desert Highway, which differs significantly from the northern region in terms of aeolian sand geomorphology and formation environment. Based on the field observation data of airflow and aeolian sand transport, continuous monitoring data of erosional and depositional processes between 14 April 2009 and 9 April 2011 and data of surface sand grains from the classical section along the southern edge of the Taklimakan Desert Highway, this paper reported the blown sand motion within the sand-control system of the highway. The main results are as follows: 1) The existing sand-control system is highly effective in preventing and controlling desertification. Wind velocities within the sand-control system were approximately 33%–100% of those for the same height above the mobile sand surface. Aeolian sand fluxes were approximately 0–31.21% of those of the mobile sand surface. Sand grains inside the system, with a mean diameter of 2.89 φ, were finer than those(2.15 φ) outside the system. In addition, wind velocities basically followed a logarithmic law, but the airflow along the classical section was mainly determined by topography and vegetation. 2) There were obvious erosional and depositional phenomena above the surface within the sand-control system, and these phenomena have very consistent patterns for all observation points in the two observed years. The total thicknesses of erosion and deposition ranged from 0.30 to 14.60 cm, with a mean value of 3.67 cm. In contrast, the deposition thicknesses were 1.90–22.10 cm, with a mean value of 7.59 cm, and the erosion thicknesses were 3.51–15.10 cm, with a mean value of 8.75 cm. The results will aid our understanding of blown sand within the sand-control system and provide a strong foundation for optimizing the sand-control system. | CHENG Hong HE Jiajia XU Xingri ZOU Xueyong WU Yongqiu LIU Chenchen DONG Yifan PAN Meihui WANG Yanzai ZHANG Hongyan | 2015 | Journal of Arid Land2015，7，5： | 8 |
| 2 | Isolation and expression pattern analysis of novel ESTs from human fetal brain显示文摘In order to learn the mechanism of brain development and differentiation, 90 expressed sequence tags (ESTs) were isolated by differential display from the cerebrum and cerebellum of 13-week and 33-week fetal brains. After searching database, 74 of them represented novel genes, some of them were homologous to the brain development related genes. Using total cDNA probes, 79 of the ESTs and their expression differences in fetal brain were further characterized. | Meihui Pan Jiangang Yuan Guangwei Du Yan Zhou Hui Yao Boqin Qiang | 1998 | Chinese Science Bulletin1998，43，21： | 3 |
| 3 | A micro-nano optogenetic system based on probiotics for in situ host metabolism regulation显示文摘Genetically engineered bacteria have aroused attention as micro-nano drug delivery systems in situ.However,conventional designs of engineered bacteria usually function constantly or autonomously,which might be non-specific or imprecise.Therefore,designing and optimizing in situ control strategy are important methodological progress for therapeutic researches of intestinal engineered bacteria.Here,a micro-nano optogenetic system based on probiotic was developed combining microelectronics,nanotechnology,and synthetic biology to achieve in situ controllable drug delivery.Firstly,optogenetic engineered Lactococcus lactis was orally administrated in the intestinal tract.A wearable optical device was designed to control optical signals remotely.Then,L.lactis could be customized to secrete peptides according to optical signals.As an example,optogenetic L.lactis system can be constructed to secrete glucagon-like peptide-1(GLP-1)under the control of the wearable optical device to regulate metabolism.To improve the half-life of GLP-1 in vivo,Fc-domain fused GLP-1 was optimally used.Using this strategy,blood glucose,weight,and other features were well controlled in rats and mice models.Furthermore,upconversion microcapsules were introduced to increase the excitation wavelength of the optogenetic system for better penetrability.This strategy has biomedical potential to expand the toolbox for intestinal engineered bacteria. | Xinyu Zhang Ning Ma Wei Ling Gaoju Pang Tao Sun Jing Liu Huizhuo Pan Meihui Cui Chunli Han Chun Yang Jin Chang Xian Huang Hanjie Wang | 2023 | Nano Research2023，16，2： | 2 |
| 4 | Cloning of a novel gene encoding human thioredoxin-like protein显示文摘mRNA differential display (DDRT-PCR) has been used to analyze different human fetal brain tissues of different developmental stages (13- and 33-week). According to the sequence of one EST obtained in this assay, a pair of primers have been designed to screen the arrayed human fetal brain cDNA library. A 1 .2-kb cDNA clone has been found. This cDNA con- | Yan Zhou Meihui Pan Jiangang Yuan Guangwei Du Boqin Qiang | 1999 | Chinese Science Bulletin1999，44，18： | 1 |
| 5 | Material patterning on substrates by manipulation of fluidic behavior显示文摘Patterned materials on substrates are of great importance for a wide variety of applications.In solution-based approaches to material patterning;fluidic flow is inevitable.Here we demonstrate not only the importance of fluidic behavior but also the methodology of engineering the flow pattern to guide the material crystallization and assembly.We show by both experiment and simulation that substrate heating;which is generally used to accelerate evaporation,produces irregular complex vortexes.Instead;a top-heating-bottom-cooling(THBC)set-up offers an inverse temperature gradient and results in a single Marangoni vortex,which is desired for ordered nanomaterial patterning near the contact line.We then realize the fabrication of large-scale patterns of iodide perovskite crystals on different substrates under THBC conditions.We further demonstrate that harnessing the flow behavior is a general strategy with great feasibility to pattern various functional materials ranging from inorganic;organic,hybrid to biological categories on different substrates,presenting great potential for practical applications. | Yitan Li Hao Wang Henglu Xu Shiting Wu Xuemei Li Jiapeng Yu Chaoyu Huang Zeyao Zhang Hao Sun Lu Han Meihui Li Anyuan Cao Zhenhai Pan Yan Li | 2019 | National Science Review2019，6，4： | 0 |
| 6 | Dust transport information and paleoclimatic changes revealed by the loess in Ranwu,south-eastern Xizang显示文摘The loess accumulation process has great potential to record patterns of atmospheric circulation change,paleoclimate,and paleoenvironmental evolution.South-eastern Xizang is a climatically sensitive region and here,we analyze a loess profile at Ranwu in order to explore the processes and interactions of dust transport and paleoclimate evolution in the region.Based on parametric grain size end-member analysis,optically stimulated luminescence(OSL)dating,and environmental proxies we show that the Ranwu loess profile comprises five end members(EMs).EM1 represents the fine silt fraction transported by high-altitude westerly winds over long distances;EM2 represents the medium silt fraction accumulated by glacier winds;EM3 is the coarse silt fraction transported by local dust storms under the action of strong glacier winds;EM4 represents the very fine sand fraction transported by strong local dust storms,different wind strengths controls the relative proportion of EM3 and EM4 over time.EM5 is the coarse sand fraction formed from the product of strong weathering of gravels.OSL dating shows loess sedimentation at Ranwu started around 11.16 ka.The prevailing climate was generally warm and wet between 11.6 and 4.2 ka,with four cooling events at 10.50,9.18,7.85,and 6.37 ka.Extensive paleosol development between 8.2 and 4.2 ka,a change to dry and cold climate conditions was favorable for loess formation after 4.2 ka.The palaeoenvironmental changes and abrupt climate events recorded in the Ranwu loess sequence are consistent with Holocene global environmental changes. | Meihui PAN Huimin ZHAO Anna YANG Yougui CHEN Chenlu LI | 2023 | Frontiers of Earth Science2023，17，4： | 0 |
| 7 | Detecting SARS-CoV-2 BA.2,BA.4,and BA.5 Variants Utilizing a Robust RT-RPA-CRISPR/Cas12a-Based Method-China,2023显示文摘Introduction:Since 2019,numerous variants of concern for severe acute respiratory syndrome virus 2(SARS-CoV-2)have emerged,leading to significant outbreaks.The development of novel,highly accurate,and rapid detection techniques for these new SARSCoV-2 variants remains a primary focus in the ongoing efforts to control and prevent the coronavirus disease 2019(COVID-19)pandemic.Methods:Reverse transcription-recombinase polymerase amplification combined with the clustered regularly interspaced short palindromic repeatsassociated protein 12a(CRISPR/Cas12a)system was used to validate the detection of the Omicron BA.2,BA.4,and BA.5 variants of SARS-CoV-2.Results:Our results demonstrate that the CRISPR/Cas12a assay is capable of effectively detecting the SARS-CoV-2 BA.2,BA.4,and BA.5 variants with a limit of detection of 10,1,and 10 copies/μL,respectively.Importantly,our assay successfully differentiated the three SARS-CoV-2 Omicron strains from one another.Additionally,we evaluated 46 SARS-CoV-2 positive clinical samples consisting of BA.2(n=20),BA.4(n=6),and BA.5(n=20)variants,and the sensitivity of our assay ranged from 90%to 100%,while the specificity was 100%.Discussion:This research presents a swift and reliable CRISPR-based method that may be employed to track the emergence of novel SARS-CoV-2 variants. | Meihui Luo Yang Pan Yaqing He Ruhan A Changcheng Wu Baoying Huang Roujian Lu Li Zhao Bo Peng Fei Ye Huijuan Wang Yuda Chen Zhen Li Daitao Zhang Wenling Wang Wenjie Tan | 2023 | China CDC weekly2023，5，26： | 0 |
| 8 | Cloning of human and mouse GRY-RBP cDNA显示文摘After screening human fetal brain cDNA library, a novel human cDNA encoding an RNA-binding protein was cloned and named GRY-RBP. Human GRY-RBP cDNA is 2 932 bp in length, and encodes a protein of 623 amino acids with a deduced molecular mass of 69.6 ku. Human GRY-RBP contains three RNA recognition motifs (RRMs) and a glycine (G), tyrosin (Y)-rich C-terminus. Computer searches with sequence database revealed its moderate homology with RRMs of many RRM RNA-binding proteins. in this study, the full coding region and partial non-coding region of mouse GRY-RBP cDNA were amplified by PCR using mouse brain cDNA library as template. Three transcripts of Gry-rbp are expressed in ali tissues as shown by Northern blot, but the amounts in heart, planceta and skeletal muscle are considerably higher than those in other tissues. | Guangwei Du Meihui Pan Yan Zhou Jianhe Chen Hui Yao Jiangang Yuan Boqin Qiang | 2000 | Chinese Science Bulletin2000，45，4： | 0 |
| 9 | Comparison of two classification methods to identify grain size fractions of aeolian sediment显示文摘Grain-size class-Std(GSCStd) and Grain-size class-dD(GSCdD) methods are simple statistical approaches for classifying bulk grain-size distributions(GSDs) into grain-size fractions. Although these two methods were developed based on similar statistical principles, the classification difference between these two methods has not been analyzed. In this study, GSCStd and GSCdD methods are conducted in thirteen grain-size data sequences to examine the applicability for identifying grain size fractions. Results show that, application of the GSCStd method is equivalent to that of the GSCdD method in identifying finer grain-size fractions, and the difference between the two methods mainly comes from the identification of coarse grain-size fractions. Thus, finer grain-size fractions are recommended for use in research of surface aeolian and paleo-aeolian sediments. In addition, our results do not completely agree with previous studies, coarser grain-size fractions in our case suggest that the GSCdD method may not be more applicable than the GSCStd method. | YanZai Wang YongQiu Wu MeiHui Pan RuiJie Lu | 2018 | Research in Cold and Arid Regions2018，10，5： | 0 |
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