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| 1 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | Correlation of high numbers of intratumoral FOXP3 regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin ' s lymphoma 显示文摘 | Tzankov A Meier C Hirschmann P Went P Pileri S A Dirnborer S | 2008 | Haernatologica2008，93，： | 1 |
| 3 | Rational treatment of empyema in children显示文摘 | Meier AH Smith B Baghavan A | 2000 | pediatr surg2000，135，8： | 1 |
| 4 | Ventilator-Associated Pneumonia in Neonatal and Pediatric Intensive Care Unit Patients 显示文摘 | Foglia E Meier M D Elward A | 2007 | Clin Microbiol Rev2007，20，3： | 1 |
| 5 | High-Performance Liquid Chromatographic Determination of Five Widespread Aglycones显示文摘 | Hasler A Stieher O Meier B | 1990 | J Chromatogr1990，508，： | 1 |
| 6 | Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury显示文摘 | Wennersten A Meier X Holmin S | 2004 | Neurosurg2004，100，1： | 1 |
| 7 | An overview of fast pyrolysis of biomass显示文摘 | Bridwater A V Meier D Radlein D | 1999 | Organic Geochemistry1999，30，： | 1 |
| 8 | Frequent EpCam protein expression in human carcinomas显示文摘 | Went PT Lugli A Meier S | 2004 | Hum Pathol2004，35，1： | 1 |
| 9 | Measured impedanceof vertical antennas over finite ground planes 显示文摘 | MEIER A S SUMMERS W P | 1949 | Proc IEEE1949，37，6： | 1 |
| 10 | Identification and determination of the flavonoids from Ginkgo biloba by high-performance liquid chromatography 显示文摘 | Hasler A Sticher O Meier B | 1992 | Journal of Chromatography A1992，605，1： | 1 |
| 11 | Identification and determination of the flavonoids from Ginkgo biloba by high performance liquid chromatography显示文摘 | Hasler A Sticher O Meier B | 1992 | J Chromatogr1992，605，： | 1 |
| 12 | Determination of lithium isotopes at natural abundance levels by atomic absorption spectrometry显示文摘 | Meier A L | 1982 | Analytical Chemistry1982，54，： | 1 |
| 13 | Mechanisms controlling the durability of thermal barrier coatings显示文摘 | EVANS A G MUMM D R HUTCHINSON J W MEIER G H Pettit F S | 2001 | Progress in Materials Science2001，46，5： | 1 |
| 14 | Correlation of molecular resist- ance mechanisms and phenotypic resistance levels in streptomycin- resistant Mycobacterium tuberculosis 显示文摘 | Meier A Sander P Schaper K J | 1996 | Antimicrob Agents Che- mother1996，40，： | 1 |
| 15 | Unexpected high com- plication rate following internal fixation of unstable proximal humerus fractures with an angled blade pate显示文摘 | Meier R A Messmer P Regazzoni P | 2006 | J Orthop Trauma2006，20，4： | 1 |
| 16 | Material and solar cell research in microcrystalline silicon显示文摘 | A V Shah J Meier Vallat-Sauvain E | | 0，，： | 1 |
| 17 | Mafic dikes displacing Witwatersrand gold reefs: evidence against metamorphic-hy drothermal ore formation显示文摘 | Meier D L Heinrich C A Watts M A | 2009 | Geology2009，37，7： | 1 |
| 18 | An overview of fast pyrolysis of biomass 显示文摘 | Bridgwater A V D Meier D Radlein | 1999 | Organic Geochemistry1999，30，12： | 1 |
| 19 | An overview of fast pyrolysis of biomass 显示文摘 | Bridgwater A V Meier D | 1999 | Organic Geochemistry1999，，3： | 1 |
| 20 | Improved sleep continuty and increased slow wave sleep and REM latency during ziprasidone treatment : a randomized, controlled, crossover trial of 12 healthy male subjects显示文摘 | Chors S Meier A Neumann AC | 2005 | J Clin Psychiatry2005，66，8： | 1 |
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