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| 1 | Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro显示文摘Sertoli 房间紧密的连接(TJ ) 是血睾丸障碍的关键部件,在它扣押开发在生精的小管以内经历精子发生的细菌房间的地方。神经质地调整的 claudin-11 是在不孕涉及障碍功能和它的鼠科的猛烈结果的批评 transmembrane 蛋白质。我们试图估计份量上到 TJ 功能的 claudin-11 的贡献的意义在 vitro,使用调停 siRNA 的基因 silencing。我们也进行了 occludin 的贡献的分析, TJ 的另一内在的 transmembrane 蛋白质。claudin-11 或 occludin 的 Silencing 在一个不成熟的老鼠 Sertoli 房间文化模型用 siRNA 被进行。Transepithelial 电的抵抗被用来在整个文化估计份量上 TJ 功能。在 siRNA 处理以后的二天,房间为对 mRNA 的 RT-PCR 评价为连接蛋白质或 lyzed 的 immunocytochemical 本地化被修理表示。claudin-11, occludin,或两个的 Silencing 在 55% 的 TJ 功能导致了重要减少(P <0.01 ) , 51%(P <0.01 ) ,并且 62%(P <0.01 ) 分别地。数据在到 Sertoli 房间 TJ 的指向的蛋白质的本地化是有在 mRNA 表示和显著减小的重要减少的伴随物。我们提供 claudin-11 显著地贡献的量的证据(P <0.01 ) 到 Sertoli 房间 TJ 在 vitro 工作。有趣地, occludin,神经质地在不孕被调整然而并非含有直到迟了的成人生活,也是一重要(P <0.01 ) 贡献者到障碍功能。我们的数据与一致在清楚地为这些表明一个角色的 vivo 研究,在维持正常 TJ 障碍的蛋白质组织并且工作。 | Mark J McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G Stanton | 2016 | Asian Journal of Andrology2016，18，4： | 7 |
| 2 | Design and testing of a three-break 800 kV SF6 circuit breaker with ZnO arrestors for shunt reactor switching 显示文摘 | McCABE A K SEYRLING G | 1992 | IEEE Transactions on Power Delivery1992，7，2： | 1 |
| 3 | EZH2inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations显示文摘 | McCabe MT Ott HM Ganji G | 2012 | Nature2012，492，： | 1 |
| 4 | Evaluating the use of goodness of fit measures in hydropic and hydro-climatic model validation 显示文摘 | LEGATES D R MCCABE G J | 1999 | Water Re- sources1999，35，1： | 1 |
| 5 | Rapid enumeration of respiratory viruses 显示文摘 | Ferris M M McCabe M O Doan L G | 2002 | Analytical Chemistry2002，74，8： | 1 |
| 6 | Multimicronutrient interventions but not vitamin A or iron interventions alone improve child growth:results of 3 meta-analyses显示文摘 | Ramakrishnan U Aburto N McCabe G | 2004 | J Nutr2004，134，10： | 1 |
| 7 | A matrix metalloproteinase gene is expressed at the boundary of senescence and programmed cell death in cucumber显示文摘 | DELORME V G R MCCABE P F KIM D J | 2000 | Plant Physiology2000，123，3： | 1 |
| 8 | The preparation of high-surface-area cordierite monolith by acid treatment显示文摘 | Shigapov A N Graham G W McCabe R W | 1999 | Applied Catalysis A: General1999，182，1： | 1 |
| 9 | Phosphorus sorption experiments and the potential for internal phosphorus loading in littoral areas of a stratified lake 显示文摘 | CYR H MCCABE S K NURNBERG G K | 2009 | Water Research2009，43，： | 1 |
| 10 | The effects of suspended silt on feeding and reproduction of Daphnia pulex 显示文摘 | McCabe G D O' Brine W J | 1983 | American Midland Naturalist1983，110，2： | 1 |
| 11 | Spatial topological con- straints in a bimanual task 显示文摘 | Franz EA Zelaznik HN McCabe G | 1991 | Acta Psychol [Amst]1991，77，2： | 1 |
| 12 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 13 | Determination of gas-bearing stability by response to a step-jump 显示文摘 | Elrod H G McCabe J T Chu T Y | 1967 | ASME J Tribology1967，89，4： | 1 |
| 14 | Cognitive functioning in chronic fatigue syndrome and the role of depression,anxiety,and fatigue显示文摘 | McCabe M Tooley G | 2002 | Psychosom Res2002，52，6： | 1 |
| 15 | Quantitative analysis of deformation twinning in zirconium 显示文摘 | McCabe R J Proust G K E | 2009 | International Journal of Plasticity2009，25，： | 1 |
| 16 | EZH2 inhibition as a thera- peutic strategy for lymphoma with EZH2 - activating mutations 显示文摘 | McCabe MT Ott HM Ganji G | 2012 | Nature2012，492，7427： | 1 |
| 17 | Spatial topological constraints in a bimanual task 显示文摘 | Franz EA Zelaznik HN McCabe G | 1991 | Acta Psychol [Amst]1991，77，2： | 1 |
| 18 | Transgenic cotton resistant to herbicide bialaphos显示文摘 | KELLER G SPATOLA L McCABE D | 1997 | Transgenic Research1997，6，： | 1 |
| 19 | Comparison of Single and Multiple Flow Direction Algorithms for Computing Topographic Parameters in TOPMODEL 显示文摘 | Wolock D M Mccabe G J | 1995 | Water Resource Research1995，，31： | 1 |
| 20 | Diabetes and mortality following acute coronary syndromes显示文摘 | DONAHOE S M STEWART G C MCCABE C H | 2007 | JAMA2007，298，： | 1 |
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