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10篇 您的检索式：作者名="Mazzolini L"

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		题名	作者	年代	出处	被引量
	1	Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.	Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero	2007	World Journal of Gastroenterology2007，13，44：	4
	2	A method for the elimination of false positives generated by the mRNA differential display technique显示文摘	Callard D Lescure B Mazzolini L	1994	Bio Techniques1994，16，6：	1
	3	Inhibition ofgene expression in mice muscle by in vivo electrically mediated siRNA delivery 显示文摘	GOLZIO M MAZZOLINI L MOLLER P	2005	Gene Ther2005，12，3：	1
	4	In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery显示文摘	Golzio M Mazzolini L Ledoux A	2007	Gene Therapy2007，14，9：	1
	5	Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery显示文摘	Golzio M Mazzolini L Moiler P	2005	Gene Ther2005，12，3：	1
	6	A method for the elimination of false positives generated by the mRNA differential display technique显示文摘	CALLARD D LESCURE B MAZZOLINI L	1994	Biotechniques1994，16，：	1
	7	A protocol for transient expression in Arabidopsis thaliana protoplasts isolated from cell suspension culture 显示文摘	Axelos M Curie C Mazzolini L Bardet C Lescure B	1992	Plant Physiol Biochem1992，30，：	1
	8	Targeted Gene Silencing into Solid Tumors with Electrically Mediated siRNAi Delivery显示文摘	Golzio M Mazzolini L Paganin-Gioanni A	2009	Methods Mol Biol2009，，555：	1
	9	Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease显示文摘	Bizeto L Mazzolini AB Ribeiro M	2008	Braz J Med Biol Res2008，41，3：	1
	10	Pulsing dendritic cells with whole tumor cell lysates 显示文摘	Alaniz L Rizzo MM Mazzolini G	2014	Methods Mol Biol2014，1139，3：	1

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