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| 1 | Combination drug regimens for metastatic clear cell renal cell carcinoma显示文摘Renal cell carcinomas(RCC)make up about 90%of kidney cancers,of which 80%are of the clear cell subtype.About 20%of patients are already metastatic at the time of diagnosis.Initial treatment is often cytoreductive nephrectomy,but systemic therapy is required for advanced RCC.Single agent targeted therapies are moderately toxic and only somewhat effective,leading to development of immunotherapies and combination therapies.This review identifies limitations of monotherapies for metastatic renal cell carcinoma,discusses recent advances in combination therapies,and highlights therapeutic options under development.The goal behind combining various modalities of systemic therapy is to potentiate a synergistic antitumor effect.However,combining targeted therapies may cause increased toxicity.The initial attempts to create therapeutic combinations based on inhibition of the vascular endothelial growth factor or mammalian target of rapamycin pathways were largely unsuccessful in achieving a profile of increased synergy without increased toxicity.To date,five combination therapies have been approved by the U.S.Food and Drug Administration,with the most recently approved therapies being a combination of checkpoint inhibition plus targeted therapy.Several other combination therapies are under development,including some in the phase 3 stage.The new wave of combination therapies for metastatic RCC has the potential to increase response rates and improve survival outcomes while maintaining tolerable side effect profiles. | Viraj V Khetani Daniella E Portal Mansi R Shah Tina Mayer Eric A Singer | 2020 | World Journal of Clinical Oncology2020，11，8： | 2 |
| 2 | Finite element and experimental studies of diameter errors in cantilever bar turning 显示文摘 | PHAN A V BARON L MAYER J | 2003 | Applied Mathematical Modeling2003，，27： | 1 |
| 3 | The Journal of Organic Chemistry显示文摘 | Mayer S F Steinreiber A Orru R V A Faber K | 2003 | 67(26):91152003，67，26： | 1 |
| 4 | ESCA-Untersuchungen an geatzten polytetrafluorathylen-folien 显示文摘 | BRECHT V H MAYER F BINDER H | 1973 | Die Angewandte Makromolekulare Chemie1973，33，1： | 1 |
| 5 | Activation of clones producing self-reactive antibodies by foreign antigen and anti-idiotype antibody carrying the internal image of the antigen显示文摘 | Bailey N C Fidanza V Mayer R | 1989 | J Clin Invest1989，84，： | 1 |
| 6 | Genetic disposition to addictive disorders - current knowledge and future perspectives 显示文摘 | Mayer P Hollt V | 2005 | Curt Opin Pharmacol2005，5，1： | 1 |
| 7 | A prospective diffusion tensor imaging study in mild traumatic brain injury显示文摘 | Mayer A R Ling J Mannell M V et aI | 2010 | Neurology2010，74，8： | 1 |
| 8 | Identification of the transcriptional activator controlling the butanediol fermentation pathway in Klebsiella terrigena显示文摘 | MAYER D SCHLENSOG V BOCK A | 1995 | Journal of Bacteriology1995，177，18： | 1 |
| 9 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 10 | Why Employees do Bad Things:Moral Disengagement and Uneth- ical Organizational Behavior 显示文摘 | Moore C Detert J R Trevifio L K Baker V L Mayer D M | 2012 | Personnel Psychology2012，65，1： | 1 |
| 11 | Shimoni bat virus,a new representative of the Lyssavirus genus显示文摘 | Kuzmin I V Mayer A E Niezgoda M | 2010 | Virus Res2010，149，： | 1 |
| 12 | Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study显示文摘 | Wiznitzer A Mayer A Novack V | 2009 | Am J Obstet Gynecnl2009，201，5： | 1 |
| 13 | Quality Labeling of Medical Web Content显示文摘 | Mayer M Karkaletsis V Archer P | 2006 | Health Informatics Journal2006，12，1： | 1 |
| 14 | A low- threshold, high-efficiency microfluidic waveguide laser 显示文摘 | Vezenov D V Mayers B T Conroy R S | 2005 | Journal of the American Chemical Society2005，127，25： | 1 |
| 15 | Prediction of diametral errors in bar turning: a computationally effective model 显示文摘 | Mayer J R R Phan A V Cloutier G | 2000 | Applied Mathematical Modelling2000，24，12： | 1 |
| 16 | Association of hipid levels during gestation with preeelampsia and gestational diavbetes mellli- tus : A population-based study 显示文摘 | Wiznitzer A Mayer A Novack V | 2009 | Am J Obstet Gynecol2009，201，5： | 1 |
| 17 | Quantifying Postoperative deficits of Physion following Spinal surgery显示文摘 | Mooney V Gatchel RT | 1989 | clin orthop1989，244，： | 1 |
| 18 | Tumor necrosis factor alpha is a key modulator of inflammation in cerebral aneurysms 显示文摘 | Javaraman T Berenstein V Mayer J | 2005 | Neurosurgery2005，57，3： | 1 |
| 19 | Aurora Kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo显示文摘 | Solc P Baran V Mayer A | 2012 | Biol Reprod2012，87，4： | 1 |
| 20 | Single cell analysis of mutations in the APC gene显示文摘 | Mayer V Schoen U Holinski-Feder E | 2009 | Fetal Diagn Ther2009，26，3： | 1 |
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