8篇
您的检索式：作者名="Matthew WT"
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| 1 | Indications and surgical options for small bowel, large bowel and perianal Crohn's disease显示文摘Despite advancements in medical therapy of Crohn's disease(CD), majority of patients with CD will eventually require surgical intervention, with at least a third of patients requiring multiple surgeries. It is important to understand the role and timing of surgery, with the goals of therapy to reduce the need for surgery without increasing the odds of emergency surgery and its associated morbidity, as well as to limit surgical recurrence and avoid intestinal failure. The profile of CD patients requiring surgical intervention has changed over the decades with improvements in medical therapy with immunomodulators and biological agents. The most common indication for surgery is obstruction from stricturing disease, followed by abscesses and fistulae. The risk of gastrointestinal bleeding in CD is high but the likelihood of needing surgery for bleeding is low. Most major gastrointestinal bleeding episodes resolve spontaneously, albeit the risk of re-bleeding is high. The risk of colorectal cancer associated with CD is low. While current surgical guidelines recommend a total proctocolectomy for colorectal cancer associated with CD, subtotal colectomy or segmental colectomy with endoscopic surveillance may be a reasonable option. Approximately 20%-40% of CD patients will need perianal surgery during their lifetime. This review assesses the practice parameters and guidelines in the surgical management of CD, with a focus on the indications for surgery in CD(and when not to operate), and a critical evaluation of the timing and surgical options available to improve outcomes and reduce recurrence rates. | James WT Toh Peter Stewart Matthew JFX Rickard Rupert Leong Nelson Wang Christopher J Young | 2016 | World Journal of Gastroenterology2016，22，40： | 2 |
| 2 | Socioeconomic differences in children' s health: how and why do these relationships change with age? 显示文摘 | Chen E Matthews KA Boyce WT | 2002 | Psychol Bull2002，128，2： | 1 |
| 3 | Obstruvtuve sleep apnea is independently associated with insulin resistance显示文摘 | Mary SM Matthew MT Kenneth WT | 2002 | Am J Respir Crit Care Med2002，165，5： | 1 |
| 4 | Is synovial C-reactive protein a useful marker for periprosthetic joint infection显示文摘 | Matthew WT Nathan GW Mario M | 2014 | Clin Orthop2014，472，12： | 1 |
| 5 | Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review显示文摘 | Matthew WT | 2000 | Biomaterials2000，21，： | 1 |
| 6 | Relationship between seed exudation and fieldemergence in peas and French beans显示文摘 | Matthews S Bradnock WT | 1968 | Horticultural Research1968，8，： | 1 |
| 7 | Albumin-induced plasma volume expansion:diurnal and temperature effects显示文摘 | Hubbard RW Matthew WT Horstman D Francesconi R Mager M Sawka MN | | 0，，05： | 1 |
| 8 | Inflammatory response after neonatal cardiac surgery and its relationship to clinical outcomes显示文摘 | Mahle WT Matthews E Kanter KR | 2014 | Ann Thorac Surg2014，97，3： | 1 |
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