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| 1 | Immune checkpoint inhibitor-induced colitis:A comprehensive review显示文摘Immune checkpoint inhibitors(ICIs) are monoclonal antibodies that target downregulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen-4, programmed cell death protein-1, and its ligand programmed death-ligand 1.ICIs have revolutionized the treatment of a variety of malignancies. However,many immune-related adverse events have also been described which mainly occurs as the immune system becomes less suppressed, affecting various organs including the gastrointestinal tract and causing diarrhea and colitis. The incidence of immune-mediated colitis(IMC) ranges from 1%-25% depending on the type of ICI and if used in combination. Endoscopically and histologically there is a significant overlap between IMC and inflammatory bowel disease,however more neutrophilic inflammation without chronic inflammation is usually present in IMC. Corticosteroids are recommended for grade 2 or more severe colitis while holding the immunotherapy. About one third to two thirds of patients are steroid refractory and benefit from infliximab. Recently vedolizumab has been found to be efficacious in steroid and infliximab refractory cases. While in grade 4 colitis, the immunotherapy is permanently discontinued, the decision is controversial in grade 3 colitis. | Aniruddh Som Rohan Mandaliya Dana Alsaadi Maham Farshidpour Aline Charabaty Nidhi Malhotra Mark C Mattar | 2019 | World Journal of Clinical Cases2019，7，4： | 14 |
| 2 | Improving sessile serrated adenoma detection rates with high definition colonoscopy:A retrospective study显示文摘BACKGROUND Sessile serrated adenomas(SSAs)are important premalignant lesions that are difficult to detect during colonoscopy due to poor definition,concealment by mucous caps,and flat appearance.High definition(HD)colonoscopy may uniquely aid in the detection of these inconspicuous lesions compared to standard definition(SD)colonoscopes.In the absence of existing clinical guidelines to obligate the use of HD colonoscopy for colorectal cancer screening in average-risk patients,demonstrating the benefit of HD colonoscopy on SSA detection rate(SSADR)may help strengthen the evidence to recommend its use in all settings.AIM To evaluate the benefit of HD colonoscopy compared to SD colonoscopy on SSADR in average-risk patients undergoing screening colonoscopy.METHODS Data from screening colonoscopies for patients aged 50-76 years two years before and two years after the transition from SD colonoscopy to HD colonoscopy at our large,academic teaching center were collected.Patients with symptoms of colorectal disease,positive occult blood test,history of colon polyps,cancer,polyposis syndrome,inflammatory bowel disease or family history of colon cancer or polyps were excluded.Patients whose endoscopists did not perform colonoscopies both before and after scope definition change were also excluded.Differences in individual endoscopist SSADR,average SSADR,and overall SSADR with SD colonoscopy vs HD colonoscopy were also evaluated for significance.RESULTS A total of 3657 colonoscopies met eligibility criteria with 2012 colonoscopies from the SD colonoscopy period and 1645 colonoscopies from the HD colonoscopy period from a pool of 11 endoscopists.Statistically significant improvements of 2.30%in mean SSADR and 2.53%in overall SSADR were noted with HD colonoscopy(P=0.00028 and P=0.00849,respectively).On the individual level,three endoscopists experienced statistically significant benefit with HD colonoscopy(+5.74%,P=0.0056;+4.50%,P=0.0278;+4.84%,P=0.03486).CONCLUSION Our study suggests that HD colonoscopy statistically significantly improves sessile serrated adenoma detection rate in the screening of average risk patients during screening colonoscopy.By improving the detection and removal of these lesions,adoption of HD colonoscopy may reduce the significant premalignant burden of sessile serrated adenomas. | Abhinav Sehgal Soorya Aggarwal Rohan Mandaliya Thomas Loughney Mark C Mattar | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 3 | Mycophenolate Mofetil Prevents the Development of Glomerulau Injury in Experimental Diabetes显示文摘 | Utimura R Fujihara C K Mattar A L | 2003 | Kidney Int2003，63，1： | 1 |
| 4 | Renal artery perfusion modifies ischemia/reperfusion injury显示文摘 | HUGHES J D MATTAR S G CHEN C | 1996 | J Surg Res1996，60，2： | 1 |
| 5 | Trends in column integrated water vapour over Europe from 1973 to 2003显示文摘 | Mattar C Sobrino J A Julien Y | 2011 | International Journal of Climatology2011，31，12： | 1 |
| 6 | Recent trends in solar exergy and net radiation at global scale显示文摘 | JIMéNEZ-MU?OZ J C SOBRINO J A MATTAR C | 2012 | Ecological Modelling2012，228，1： | 1 |
| 7 | Preoperative serum levels of CA72-4, CEA, CA19-9 and alpha-fetoprotein in patients with gastric cancer显示文摘 | Mattar R Andrade C R Difavero G M | 2002 | Rev Hosp Clin Fac Med Uni Sao Paulo2002，57，3： | 1 |
| 8 | A Combined Opti cal Microwave Method to Retrieve Soil Moisture over Vegeta ted Areas显示文摘 | Mattar C Wigneron J P Sobrino J A | 2012 | IEEE Transactions on Geoscience and Remote Sensing2012，50，5： | 1 |
| 9 | A combined optical-microwave method to retrieve soil moisture over vegetated areas显示文摘 | Mattar C Wigneron J P Sobrino J A | 2012 | IEEE Transactions on Geoscience and Remote Sensing2012，50，5： | 1 |
| 10 | Tight Gas Produc- tion Performance Using Decline Curves 显示文摘 | Kupchenko C L Gault B W Mattar L | 2008 | SPE1149912008，，： | 1 |
| 11 | Prescription and Adherence to Statins of Patients With Coronary Artery Disease and Hypercholesterolemia显示文摘 | Mansur A P Mattar A P Tsubo C E | 2001 | Arq Bras Cardiol2001，76，2： | 1 |
| 12 | Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes 显示文摘 | Utimura R Fujihara C K Mattar A L | 2003 | Kidney Int2003，63，1： | 1 |
| 13 | Adverse pregnancy out- comes in women with diabetes 显示文摘 | Negrato C A Mattar R Gomes M B | 2012 | Diabetol Metab Syndr2012，4，1： | 1 |
| 14 | Renal expression of COX-2,ANG Ⅱ, and AT1 receptor in remnant kidney: strong renoprotec-tion by therapy with Iosartan and a nonsteroidal anti-inflammatory 显示文摘 | Goncalves A R Fujihara C K Mattar A L et aI | 2004 | Am J Physiol Renal Physio2004，1286，： | 1 |
| 15 | A combined Optical - Microwave method to retrieve soil moisture over vegetated areas 显示文摘 | Mattar C Wigneron J P Sobrino J A | 2012 | IEEE Transactions on Geoscience and Remote Sensing2012，50，5： | 1 |
| 16 | Myeophenolate mofetil prevents the development of glomerular injury in experimental diabeles显示文摘 | Utimura R Fujihara C K Mattar A L Malheiros D M Noronha I L Zatz R | 2003 | Kidney Int2003，63，： | 1 |
| 17 | Mycophenolate mofetil prevents the development of glomerular injury in experimental diabete显示文摘 | Utimura R Fujihara C K Mattar A L | 2003 | Kidney Int2003，63，1： | 1 |
| 18 | Case report and review of literature: coronary artery fistulae 显示文摘 | Mechleb W Abboud L Mattar C | | Tenn Med0，106，7： | 1 |
| 19 | Mycophenolate mofetil prevents the development of glomerular injury in experiment Diabetes显示文摘 | Utimura R Fujihara C K Mattar A I | 2003 | Kidney Int2003，63，1： | 1 |
| 20 | Myeophenolate mofetil prevents the development of glomerular injury in experimental diabetes显示文摘 | Utimura R Fujihara C K Mattar A L | 2003 | Kidney Int2003，63，1： | 1 |
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