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| 1 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022,28,14: | 3 |
| 2 | The persistence in the liver of residual duck hepatitis B virus covalently closed circular DNA is not dependent upon new viral DNA synthesis显示文摘 | Reaiche GY Le Mire MF Mason WS | 2010 | Virology2010,406,2: | 1 |
| 3 | Multi kJ level Laser Concepts for HiPER Facility显示文摘 | J-C Chanteloup D Albach A Lucianetti K Ertel S Banerjee P D Mason C Hernandez-Gomez J L Collier J Hein M Wolf J K?rner B J Le Garrec | 2010 | Journal of Physics: Conference Series2010,,1: | 1 |
| 4 | Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats 显示文摘 | Wold LE Dutta K Mason MM | 2005 | J Mol Cell Cardiol2005,39,: | 1 |
| 5 | The persistence in the liver of residual duck hepatitis B virus covalently closed circular DNA is not dependent upon new viral DNA synthesis显示文摘 | Reaiche GY Le Mire MF Mason WS Jilbert AR | | Virology0,,: | 1 |
| 6 | Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats显示文摘 | Wold LE Dutta K Mason MM | | 0,,02: | 1 |
| 7 | A highly hydratedα-cyclodextrin/1-undecanol inclusion complex:crystal structure and hydrogen-bond network from high-resolution neutron diffraction at 20 K Tetrahedron Letters显示文摘 | Delphine Gallois-Montbrun Geneviève Le Bas Sax A Mason | 2013 | Acta Cryst2013,69,2: | 1 |
| 8 | Kinetics of Cryptosporidium parvum sporozoite neutralization by monoclonal anti- bodies, immune bovine serum, and immune bovine colostrum显示文摘 | Perryman LE Riggs MW Mason PH | 1990 | Infect Immun1990,58,1: | 1 |
| 9 | A recombinant ca narypox virus protects rabbits against a lethal rabbit hemor rhagic disease virus (RHDV) challenge显示文摘 | Fischer L Le Gros F X Mason P W | 1997 | Vaccine1997,15,1: | 1 |
| 10 | Three-dimension- al sonography of the endometrium and adjacent myometri- um: preliminary observations 显示文摘 | Andreotti RF Fleischer AC Mason LE | 2006 | J Ultrasound Med2006,25,10: | 1 |
| 11 | Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats显示文摘 | Wold LE Dutta K Mason MM | 2005 | J Mol Cell Cardiol2005,39,2: | 1 |
| 12 | Podoeyte detachment and reduced glomerular capillary endothelial fenestration pro- mote kidney disease in type 2 diabetic nephropathy显示文摘 | Weil Le mLey KV Mason CC | 2012 | Kidney Int2012,82,9: | 1 |
| 13 | Primary structure and biological activity of human-derived neurotrophic factor显示文摘 | Rosenthal A Goeddel DV Nguyen T Martin E Burton LE Shih A Laramee GR Wurm F Mason A Nikolics K Winslow JW | | 0,,: | 1 |
| 14 | Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice显示文摘 | Perryman LE Mason PH Chrisp CE | 1994 | Infect Immun1994,62,: | 1 |
| 15 | TOBI image processing-the state of the art显示文摘 | LE BAST P MASON D C MILLARD N C | 1995 | IEEE Journal of Oceanic Engineering1995,20,1: | 1 |
| 16 | Intensivemethotrexate and cytarabine followed by high-dosechemotherapy with autologous stem-cell rescue in patientswith newly diagnosed primary CNS lymphoma:an intent-to-treat analysis显示文摘 | Abrey LE Moskowitz CH Mason WP | 2003 | J Clin Oncol2003,21,22: | 1 |
| 17 | A double-blind, placebo-controlled, randomized trial of oral sodium clodronate for metastatic prostate cancer (MRC PR05 Trial)显示文摘 | Dearnaley DP Sydes MR Mason MD Stott M Powell CS Robinson AC Thompson PM Moffat LE Naylor SL Parmar MK Mrc Pr05 Collaborators | 2003 | Journal of the National Cancer Institute2003,95,17: | 1 |