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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Macroinvertebrate drift density in relation to abiotic factors in the Missouri river 显示文摘 | Hay C H Franti T G Marx D B | 2008 | Hydrobiologia2008，598，： | 1 |
| 3 | The influence of recent life experience on the health of college freshmen显示文摘 | Marx M B Garring T F Bowers F R | 1975 | Journal of psychosomatic research1975，，19： | 1 |
| 4 | Reliability of an ear-bow transferinstrument 显示文摘 | Dae Gyun Choi John F Bowley David B Marx | 1999 | J Prosthet Dent1999，82，： | 1 |
| 5 | Flexible Smoothing with B-Splines and Penalties显示文摘 | Eilers P H C Marx B D | 1996 | Statistical Science1996，11，2： | 1 |
| 6 | Thioredoxin and germinating barely:targets and protein redox changes显示文摘 | MARX C WONG J H BUCHANAN B B | 2003 | Planta2003，216，： | 1 |
| 7 | Immunization with beta-amyloid:Could T-cell activation have a harmful effect?显示文摘 | Grubeck-Loebenstein B Blasko I Marx F K | 2000 | Trends Neurosci2000，23，3： | 1 |
| 8 | Cloning, structural organization and regulation of expression of the Penicillium chrysogenum paf gene encoding an abundantly secreted protein with antifungal activity显示文摘 | Marx F Haas H Reindl M Stoffler G Lottspeich F Redl B | 1995 | Gene1995，167，1： | 1 |
| 9 | Evaluation of prognostic features in thymic epithelial tumors显示文摘 | Schalke B Marx A | 1989 | Thymus1989，14，： | 1 |
| 10 | Evaluation of non invasive determinants for capillary leakage syndrome in septic shock patients显示文摘 | Marx G Vangerow B Burczyk C | 2000 | Intensive Care Med2000，26，9： | 1 |
| 11 | Linking teacher and student learning to improve professional development in systemic reform显示文摘 | Fishman B J Marx R W | 2003 | Teaching and Teacher Education2003，19，6： | 1 |
| 12 | Thrombinactivatable fibrinolysis inhi-bitor (TAFI, Plasma procarboxypeptidase B, procarboxypeptidase R, procarboxypeptidase U) 显示文摘 | Bouma B N Marx P F Mosnier L O | 2001 | Thromb Res2001，101，5： | 1 |
| 13 | Rhabdomyosarcoma lysis by T cells expressing a human autoantibody-based chimeric re- ceptor targeting the fetal acetylcholine receptor 显示文摘 | Gattenlohner S Marx A Markfort B | 2006 | Cancer Res2006，66，1： | 1 |
| 14 | Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients显示文摘 | Marx G Vangerw B Burczyk C | 2000 | Intensive Care Med2000，26，9： | 1 |
| 15 | Assessing Distress in Pediatric Intensive Care Environments:the COMFORT Scale显示文摘 | Ambuel B Hamlett K W Marx C M | | 0，，01： | 1 |
| 16 | Metabolic phenotype of phosphoglucose isomerase mutants of Corynebocterium glutamicum显示文摘 | Marx A Hans S Mkel B | | 0，，： | 1 |
| 17 | Medication beliefs predict medication adherence in older adults with multiple illnesses显示文摘 | Schüz B Marx C Wurm S | 2011 | Journal of Psychosomatic Research2011，70，2： | 1 |
| 18 | Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients 显示文摘 | Marx G Vangerow B Burezy KC | 2000 | Intensive Care Med2000，26，9： | 1 |
| 19 | Evaluation of noninvasive determinants for capillary leakage syndrome in septic shock patients 显示文摘 | Marx G Vangerow B Burczyk C | 2000 | Intensive Care Med2000，26，9： | 1 |
| 20 | Hl-fihering and state feedback control for dis- crete-time switched descriptor systems显示文摘 | Koenig D Marx B | 2009 | IET Control Theory and Applications2009，3，6： | 1 |
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