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| 1 | Short-term effectiveness of golimumab for ulcerative colitis: Observational multicenter study显示文摘AIM To evaluate the real-world effectiveness of golimumab in ulcerative colitis(UC) and to identify predictors of response.METHODS We conducted an observational, prospective and multi-center study in UC patients treated with golimumab, from September 2014 to September 2015. Clinical activity was assessed at wk 0 and 14 with the physician's global clinical assessment(PGA) and the partial Mayo score. Colonoscopies and blood tests were performed, following daily-practice clinical criteria, and the results were recorded in an SPSS database.RESULTS Thirty-three consecutive patients with moderately to severely active UC were included. Among them, 54.5% were female and 42 years was the average age. Thirty percent had left-sided UC(E2) and 70% had extensive UC(E3). All patients had an endoscopic Mayo score of 2 or 3 at baseline. Twenty-seven point three percent were anti-tumor necrosis factor(TNF) treatment na?ve, whereas 72.7% had previously received infliximab and/or adalimumab. Sixty-nine point seven percent showed clinical response and were steroid-free at wk 14(a decrease from baseline in the partial Mayo score of at least 3 points). Based on PGA, the clinical remission and clinical response rates were 24% and 55% respectively. Withdrawal of corticosteroids was observed in 70.8% of steroid-dependent patients at the end of the study. Three out of 10 clinical non-responders needed a colectomy. Mean fecal calprotectin value at baseline was 300 μg/g, and 170.5 μg/g at wk 14. Being anti-TNF treatment na?ve was a protection factor, which was related to better chances of reaching clinical remission. Twenty-seven point three percent of the patients required treatment intensification at 14 wk of followup. Only three adverse effects(AEs) were observed during the study; all were mild and golimumab was not interrupted.CONCLUSION This real-life practice study endorses golimumab's promising results, demonstrating its short-term effectiveness and confirming it as a safe drug during the induction phase. | Marta Maia Bosca-Watts Xavier Cortes Marisa Iborra Jose Maria Huguet Laura Sempere Gloria Garcia Rafa Gil Mari Fe Garcia Marga Munoz Pedro Almela Nuria Maroto Jose Maria Paredes | 2016 | World Journal of Gastroenterology2016，22，47： | 5 |
| 2 | The grafting of triploid watermelon is an advantageous alternative to soil fumigation by methyl bromide for control of Fusarium wilt显示文摘 | A. Miguel J.V. Maroto A. San Bautista C. Baixauli V. Cebolla B. Pascual S. López J.L. Guardiola | 2004 | Scientia Horticulturae2004，，1： | 2 |
| 3 | Fast detection of salmonella infantis with carbon nanotube field effect transistors显示文摘 | VILLAMIZAR R A MAROTO A RIUS F X | 2008 | Biosensors & Bioelectronies2008，24，2： | 1 |
| 4 | Cosmic magnetic fields and dark energy in extended electromagnetism显示文摘 | JIMENEZ J B MAROTO A L | 2011 | J Phys Conf Ser2011，314，01： | 1 |
| 5 | Dilared and contracted forms of primary endocardial fibroelastosis:a single fetal disease with two stages of development显示文摘 | CARCELLER A M MAROTO E FOURON J C | 1990 | Br Heart J1990，63，5： | 1 |
| 6 | A robust genetic algorithm for resource allocation in project scheduling显示文摘 | ALCARAZ J MAROTO C | 2001 | Annals of Operations Research2001，102，1234： | 1 |
| 7 | Solving the flowshop scheduling problem with sequence dependent setup times using advanced metaheuristics 显示文摘 | RUIZ R MAROTO C ALCARAZ J | 2005 | European Journal of Operational Research2005，，165： | 1 |
| 8 | Improved detection of Candida alblcans with carbon nanotube field-effect transistors显示文摘 | VILLAMIZAR R A MAROTO A RIUS F X | 2009 | Sensors and Actuators B-Chemical2009，136，2： | 1 |
| 9 | Effect of grafting and cytolinin-induced fruit setting on colour and sugar-content traits in glasshouse-grow triploid watermelon显示文摘 | Lopez-Galarza S Bautista A S Perez D M Miguel A Baixauh C Pascual B Maroto J V Guardiola J L | 2004 | Journal of Horticultural Science&Biotechnology2004，79，6： | 1 |
| 10 | A robust genetic algorithm for resource allocation in project scheduling 显示文摘 | ALCARAZ J MAROTO C | 2001 | Annals of Operation Research2001，102，1： | 1 |
| 11 | Treatment of a non -vitaimmature incisor with mineral trioxide aggregate(MTA)显示文摘 | Maroto M Barberia E Planells P et ai | 2003 | Dentaltraumatology2003，19，： | 1 |
| 12 | The grafting of triploid watermelon is an advantageous alternative to soil fumigation by methyl bromide for control of Fusarium wilt 显示文摘 | Miguel A Maroto J V San Bautista A | 2004 | Scientia Horticulturae2004，103，： | 1 |
| 13 | Dilated and contracted forms of pri mary endocardial fibroelastosis:A single fetal disease with two stages of development 显示文摘 | Carceller AM Maroto E Fouron JC | 1990 | Br Heart J1990，63，5： | 1 |
| 14 | A comprehensive review and evaluation of permutation flow shop heuristics显示文摘 | Ruiz R Maroto C | 2005 | European Journal of Operational Research2005，165，： | 1 |
| 15 | Two new robust genetic algorithms for the flowshop scheduling problem显示文摘 | RUIZ R MAROTO C ALCARAZ J | 2006 | Omega2006，34，5： | 1 |
| 16 | A comprehensive review and evaluation of permutation flowshop heuristics 显示文摘 | Ruiz R Maroto C | 2005 | European Journal of Operational Research2005，165，： | 1 |
| 17 | A comprehensive review and evaluation of permutation flowshop heuristies显示文摘 | RUBEN R MAROTO C | 2005 | European Journal of Operational Research2005，165，2： | 1 |
| 18 | Plants as chemical factories for the production of polyunsaturated fatty acids 显示文摘 | Lopez Alonso D Garcia Maroto F | 2000 | Biotechnology Advances2000，18，： | 1 |
| 19 | Contribution of free and g显示文摘 | ?AI OMO E S PEREZ COELLO M S DIAZ MAROTO M C | 2006 | Food Chemistry2006，95，2： | 1 |
| 20 | Rufilanchas intracardiae thrombus trapped in a patent foramen ovale 显示文摘 | Maroto LC Molina L Carrascal Y | 1997 | Eur J Cardiothorac Surg1997，12，： | 1 |
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