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6篇 您的检索式:作者名="Marnix L"
    题名 作者 年代 出处 被引量
1Averaged EMG profiles in jogging and running at different speeds显示文摘MARNIX G J GAZENDAM A AT L HOF 2007Gait Posture2007,,25:1
2Proof of super valent doping in olivine LiFePO4 显示文摘Marnix Wagemaker Brian L Ellis 2008Chem Mater2008,,20:1
3Current methods for loading dendritic cells with tumor antigen for the induction of antitumor immunity显示文摘Bosch Z Marnix L Michael L 2002Immunotherapy2002,25,:1
4Foot and ankle sonography显示文摘David P Fessel L Marnix T 0,,04:1
5Foot and ankle sonography显示文摘David P Fessel L Marnix T 1999Radiol Clin North Am1999,37,4:1
6Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis显示文摘AIM: To investigate if azathioprine could reduce adenoma formation in ApcMin/+, a mouse model of sporadic intestinal tumorigenesis.METHODS:Azathioprine was administered via drinking water(estimated 6-20 mg/kg body weight per day)to ApcMin/+and wildtype mice.Control animals received vehicle only(DMSO)dissolved in drinking water.At 15wk of age all mice were sacrificed and intestines of ApcMin/+were harvested for evaluation of polyp number.Azathioprine induced toxicity was investigated by immunohistochemical analysis on spleens.RESULTS:All azathioprine treated mice showed signs of drug-associated toxicity such as weight loss and development of splenic T-cell lymphomas.Although this suggests that the thiopurine concentration was clearly in the therapeutic range,it did not reduce tumor formation(48±3.1 adenomas vs 59±5.7 adenomas,P=0.148).CONCLUSION:We conclude that in the absence of inflammation,azathioprine does not affect intestinal tumorigenesis.Mattheus CB Wielenga Jooske F van Lidth de Jeude Sanne L Rosekrans Alon D Levin Monique Schukking Geert RAM D'Haens Jarom Heijmans Marnix Jansen Vanesa Muncan Gijs R van den Brink 2014World Journal of Gastroenterology2014,20,44:0
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