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| 1 | The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study显示文摘Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group study.Methods:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-time.Subjects received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total score.Results:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was demonstrated.The incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole IR.The safety profiles of pramipexole ER and IR were similar.These results were based on comparable mean daily doses and durations of treatment for both formulations. | Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng Liu Yiming Liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 2 | Deep Bayesian local crystallography显示文摘The advent of high-resolution electron and scanning probe microscopy imaging has opened the floodgates for acquiring atomically resolved images of bulk materials,2D materials,and surfaces.This plethora of data contains an immense volume of information on materials structures,structural distortions,and physical functionalities.Harnessing this knowledge regarding local physical phenomena necessitates the development of the mathematical frameworks for extraction of relevant information.However,the analysis of atomically resolved images is often based on the adaptation of concepts from macroscopic physics,notably translational and point group symmetries and symmetry lowering phenomena.Here,we explore the bottom-up definition of structural units and symmetry in atomically resolved data using a Bayesian framework.We demonstrate the need for a Bayesian definition of symmetry using a simple toy model and demonstrate how this definition can be extended to the experimental data using deep learning networks in a Bayesian setting,namely rotationally invariant variational autoencoders. | Sergei V.Kalinin Mark P.Oxley Mani Valleti Junjie Zhang Raphael P.Hermann Hong Zheng Wenrui Zhang Gyula Eres Rama K.Vasudevan Maxim Ziatdinov | 2021 | npj Computational Materials2021，，1： | 3 |
| 3 | Fragmented nature: consequences for biodiversity显示文摘 | Han O Mark ER | 2002 | Landscape and Urban Planning2002，，58： | 1 |
| 4 | Effect of a Herbal-Leucine mix on the IL-1β induced cartilage degradation and inflammatory gene expression in human chondrocytes显示文摘 | Nahid Akhtar Mark JS Mil er Tariq M Haqqi | | 0，，： | 1 |
| 5 | It's time to rethink mite allergen avoidance显示文摘 | Tovey ER Marks GB | 2011 | J Allergy Clin Immunol2011，128，4： | 1 |
| 6 | Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients显示文摘 | Marks L Altman NH Podack ER | 2004 | Transplantation2004，77，6： | 1 |
| 7 | The Strenth of Weak Tie 显示文摘 | GRANNOVETI'ER MARK | 1973 | American Journal of Sociology1973，，78： | 1 |
| 8 | A Balance Sheet Approach to FinancialCrisis显示文摘 | Allen Mark Christoph Rosenberg Christian Keller Brad Seds- er and Nouriel Roubini | 2003 | IMF Working Paper2003，，： | 1 |
| 9 | The establishment success of native versus non-native herbaceous seed mixes on a revegetated roadside in Central Texas 显示文摘 | M Jeannine Tinsley Mark T Simmons Steve Windhag- er | 2006 | Ecological Engineering2006，，26： | 1 |
| 10 | Assessment of disease progress in psoriasis显示文摘 | Marks R Barton SP Shuttleworth D er al | 1989 | Arch Dermatol1989，125，2： | 1 |
| 11 | It' s time to rethink mite allergen avoidance 显示文摘 | Tovey ER Marks GB | 2011 | J Allergy Clin Immunol2011，128，： | 1 |
| 12 | Administration of colony stimulating factor-1 corrects some macrophage,dental,and skeletal defects in an osteopetrotic mutation (toothless,tl) in the rat显示文摘 | Marks SC Jr Wojtowicz A Szperl M Urbanowska E MacKay CA Wiktor-Jedrzejczak W Stanley ER Aukerman SL | | 0，，： | 1 |
| 13 | The Strength of Weak Tie显示文摘 | Mark Granovet er | | 0，，： | 1 |
| 14 | Gamma knife thalamommy for treatment of tremor: long-term results 显示文摘 | Young RF Jacques S Mark R er al | 2000 | J Neurosurg2000，93，3： | 1 |
| 15 | Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity显示文摘 | Gerencser AA Mark KA Hubbard AE er al | 2009 | J Neurochcm2009，110，3： | 1 |
| 16 | Anterior access to the lumbar spine:laparoscopic versus open/discussion显示文摘 | Heron ER Mark MC Henna D | 2002 | The American Surgeon2002，68，11： | 1 |
| 17 | Role of the Renin-Angiotensin-Aldosterone System in the progression of renal disease:A critical review显示文摘 | Hassan NI Mark ER Thomas H | 1997 | Semi in Nephrol1997，17，： | 1 |
| 18 | Donor T cells lacking fas ligand and perforin retain the capacity to induce severe GVHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipieuts 显示文摘 | Marks L Altman NH Podack ER | 2004 | Transplantation2004，77，6： | 1 |
| 19 | A Role for the P2X Receptor in Urinary Tract Physiology and in the Pathophysiology of Urinary Dysfunction显示文摘 | DAVID ER MARK BL GREGORY TB | 2005 | Euro Urol2005，48，2： | 1 |
| 20 | A Critical Com- parison of the 4-Intesection and 9-Intersection Mod els for Spatial Relations: Formal Analysis显示文摘 | Egenho{er M Sharma J Mark D | 1993 | Au- toCarto1993，11，： | 1 |
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