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| 1 | Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study显示文摘AIM:To determine the long-term hepatobiliary complications of alveolar echinococcosis(AE) and treatment options using interventional methods.METHODS:Included in the study were 35 patients with AE enrolled in the Echinococcus Multilocularis Data Bank of the University Hospital of Ulm.Patients underwent endoscopic intervention for treatment of hepatobiliary complications between 1979 and 2012.Patients' epidemiologic data, clinical symptoms, and indications for the intervention, the type of intervention and any additional procedures, hepatic laboratory parameters(pre- and post-intervention), medication and surgical treatment(pre- and post-intervention), as well as complications associated with the intervention and patients‘ subsequent clinical courses were analyzed.In order to compare patients with AE with and without history of intervention, data from an additional 322 patients with AE who had not experienced hepatobiliary complications and had not undergone endoscopic intervention were retrieved and analyzed.RESULTS:Included in the study were 22 male and 13 female patients whose average age at first diagnosis was 48.1 years and 52.7 years at the time of intervention.The average time elapsed between first diagnosis and onset of hepatobiliary complications was 3.7 years.The most common symptoms were jaundice, abdominal pains, and weight loss.Thenumber of interventions per patient ranged from one to ten.Endoscopic retrograde cholangiopancreatography(ERCP)was most frequently performed in combination with stent placement(82.9%),followed by percutaneous transhepatic cholangiodrainage(31.4%)and ERCP without stent placement(22.9%).In 14.3%of cases,magnetic resonance cholangiopancreatography was performed.A total of eight patients received a biliary stent.A comparison of biochemical hepatic function parameters at first diagnosis between patients who had or had not undergone intervention revealed that these were significantly elevated in six patients who had undergone intervention.Complications(cholangitis,pancreatitis)occurred in six patients during and in 12patients following the intervention.The average survival following onset of hepatobiliary complications was 8.8years.CONCLUSION:Hepatobiliary complications occur in about 10%of patients.A significant increase in hepatic transaminase concentrations facilitates the diagnosis.Interventional methods represent viable management options. | Tilmann Graeter Franziska Ehing Suemeyra Oeztuerk Richard Andrew Mason Mark Martin Haenle Wolfgang Kratzer Thomas Seufferlein Beate Gruener | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 2 | Brain GABA levels in patients with bipolar disorder显示文摘 | Kaufman RE Ostacher MJ Marks EH | 2009 | Prog Neuropsychopharmacol Biol Psychiatry2009，33，3： | 1 |
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| 4 | Susceptibility weighted imaging (SWI)显示文摘 | Mark EH | 2004 | Magnetic Resonance in Medicine2004，52，： | 1 |
| 5 | The diagnostic and therapeutic roles of colonoscopy: a review显示文摘 | HUANG EH MARKS JM | 2001 | Surg Endosc2001，15，12： | 1 |
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| 7 | The hERG potassium channel and hERG screening for drug - induced torsades de pointes显示文摘 | Jules CH Mark JM Aziza EH | 2008 | Phar- macol Ther2008，119，2： | 1 |
| 8 | Brain GABA levels in patients with bipolar disorder显示文摘 | Kaufman RE Ostacher MJ Marks EH | 2009 | Progress in Neuro-Psychopharmacology & Biological Psychiatry2009，33，3： | 1 |
| 9 | Long-term dynamics of pine and hardwood litter in contrasting environments: toward a global model of decomposition 显示文摘 | Gholz HL Wedin DA Smitherman SM Mark EH William JP | 2000 | Global Change Biol2000，6，： | 1 |
| 10 | Anterior tibial tendon transfer in re- sidual dynamic elubfoot deformity显示文摘 | Ken NK Shawn PH Mark EH | 2001 | J Pediatr Orthop2001，21，： | 1 |
| 11 | Changes in neurite outgrowth but not in cell division induced by low EMF exposure,influence of field strength and culture condition on responses in rat PC12 pheochromocytoma cells显示文摘 | McFarlane EH Dawe GS Marks M | 2000 | Bioelectrochemistry2000，52，1： | 1 |
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