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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Sequence structure of 12novel Y chromosome microsatellites and PCR amplification strategies显示文摘 | Annabel GN Mike E Maria VL | 2001 | Forensic Sci Int2001，122，： | 1 |
| 3 | A- 174G/C polymorphism of the interleukin - 6 gene in pzitients with lacunar infarction显示文摘 | Maria'n Revilla Vl'ctor Obach A' lvaro Cervera | 2002 | Neuroscience Letters2002，324，： | 1 |
| 4 | Sequence structure of 12 novel Y chromosome microsatellites and PCR amplification strategies显示文摘 | Annabel GN Mike E Maria VL | 2001 | Forensic Sci Int2001，122，1： | 1 |
| 5 | Sequence structure of 12 novel Y chromosome microsatellites and PCR amplification strategies显示文摘 | Annabel GN Mike E Maria VL | 2001 | Forensic Sci Int2001，122，： | 1 |
| 6 | Successful treatment of Plasmodium falciparum malaria with a six-dose regimen of artemether-lumefantrine versus quinine-doxycycline in the western amazon region of brazil显示文摘 | Maria GA Marcus VL | 2006 | AmJ TropMed Hyg2006，74，1： | 1 |
| 7 | Clinical, genetic and molecular features in 45 patients with Prader-Willi syndrome 显示文摘 | Cortes MF Alliende RMA Barrios RA Curotto LB Santa Maria VL Barraza OX | 2005 | Rev Med Chil2005，133，1： | 1 |
| 8 | Sequence structure of 12 novel Y chromosome microsatellites and PCR amplification strategies显示文摘 | Mike E Maria VL | 2001 | Forensic Sci Int2001，122，： | 1 |
| 9 | Sequence structure of 12 novel Y chromosome microsatellites and PCR amplification strategies显示文摘 | Annabel GN Mike E Maria VL | 2001 | Forensic Sci Int2001，122，： | 1 |
| 10 | Sequence structure of 12 novel Y chromosome microsatellites and PCR amplification strategies 显示文摘 | Annabel GN Mike E Maria VL | 2001 | Forensic Sci Int2001，122，： | 1 |
| 11 | Sequence structure of novel Y chromosome micro-satelites and PCR amplification strategies显示文摘 | Annable GN Mike E Maria VL | 2001 | Forensic Sci Int2001，122，： | 1 |
| 12 | Autoimmune/inflammatory syndrome induced by adjuvants(Shoenfeld'ssyndrome):clinical and immunological spectmm显示文摘 | Olga VL Gabriela M Maria DP | 2013 | ExpertRev Clin Immuno2013，9，4： | 1 |
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