|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 3 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 4 | Outcome of cytomegalovirus infections in patients with inflammatory bowel disease显示文摘 | Konstantinos A Papadakis Jim K Tung Scott W Binder Lori Y Kam Maria T Abreu Stephan R Targan Eric A Vasiliauskas | 2001 | The American Journal of Gastroenterology2001，，7： | 2 |
| 5 | Car- diovagal response to acute mild exercise in young healthy subjects显示文摘 | Gizegore R Gian D P Maria T L R | 2005 | Circ J2005，69，： | 1 |
| 6 | Improvement of the waste oil vacuum distillation recycling by continuous extraction with dense propane 显示文摘 | Jesusa R Pablo C Maria T G | 2007 | Industrial & Engineering Chemistry Research2007，46，1： | 1 |
| 7 | Processof Lemongrass Essential oil: Physicochemical Characteriza-tion and Assessment Quality of the Distillate and the ResidueProducts 显示文摘 | LAURA P T GLAUCIA M F P MARIA R W | 2011 | Industrial & Engineering Chemistry Research2011，50，13： | 1 |
| 8 | Regeneration of used lubricant oil by ethane extraction 显示文摘 | Jesusa R Pablo C Maria T G | 2007 | Journal of Supercritical Fluids2007，39，3： | 1 |
| 9 | Three-dimensional model of the melt blowing process显示文摘 | Maria V T Shambaugh R L | 2003 | Industrial & Engineering Chemistry Research2003，42，26： | 1 |
| 10 | Metal -ion sensing fluorophores with large two - photon absorption cross sections: aza - crown ether substituted donor - acceptor - donor distyryjbenzenes 显示文摘 | Stephanie J K P Osamu T Maria C R | 2004 | J Am Chem Soc2004，126，： | 1 |
| 11 | High Temperature Mechanical Behavior of a 30% Ni - 19% Cr Steel 显示文摘 | Jose A J Oscar A R Maria T L | 2003 | ISIJ International2003，，12： | 1 |
| 12 | Spectrophotometric assay using o - phtaldialdehyde for thedetermination of transglutaminase activity on casein 显示文摘 | Caterina D Maria T G Rocco R | 2002 | Food Chemistry2002，78，： | 1 |
| 13 | Nucleation and growth of hydroxyapatite on titanium pretreated in NaOH solution: Experiments and thermody- namic explanation显示文摘 | de Andrade M C Filgueiras Maria R T Ogasawara Tsune- haru | 1999 | J Biomed Mater Res Part B1999，46，4： | 1 |
| 14 | Oxidative stability ofpork meat lipids as related to high-loeic sunflower oil andvitamin E diet supplementation and storage conditions 显示文摘 | Vladimiro C Maria T R Fabio C | 2011 | Meat Science2011，88，2： | 1 |
| 15 | Acetylcholinesterase-based biosensors for quantification of carbofuran,carbaryl,methylparaoxon,and dichlorvosin 5% acetonitrile显示文摘 | GABRIELA V R MONTSERRAT C MARIA T R S | 2008 | Anal Bioanal Chem2008，392，： | 1 |
| 16 | Characterization of short chain fatty acid microcapsules produced by spray drying 显示文摘 | Maria I T Leonardo R A Farina M | 2004 | Materials Science and Engineering2004，24，5： | 1 |
| 17 | Health-related quali- ty of life in coronary heart disease compared to norms in Spanish population显示文摘 | Maria S T Soledad M C Ignacio R D | 2004 | Quality of Life Research2004，13，8： | 1 |
| 18 | The role of capillary water in the stability of tailing dams显示文摘 | MARIA T Z LUCIANO A O ROBERTO R | 2009 | Engineering Geology2009，105，2： | 1 |
| 19 | Acetate as a carbon source for hydrogen production by photosynthetic bacteria显示文摘 | MARIA J B JORGE M S R JOHANNES T | 2001 | J Biotechnol2001，85，1： | 1 |
| 20 | Study of Some Physical Properties of Biodegradable Films Based on Blends of Gelatin and Poly( vinyl alcohol) using a Response-surface Methodology显示文摘 | Carvalho R A Maria T M C Moraes I C F | 2009 | Materials Science and Engineering C2009，29，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员