|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Methylation of TIMP3 in esophageal squamous cell carcinoma显示文摘AIM: To measure the frequency of DNA methylation of the tissue inhibitor of metalloproteinase 3 (TIMP3) promoter and relate this to any change of gene expression in esophageal squamous cell carcinoma in patients from a region of high incidence in China.METHODS: Cancer cell lines were treated with or without the demethylating reagent 5-aza-2’-deoxycytidine. Methylation of the TIMP3 promoter was assessed in three regions by melt curve analysis and its expression was assessed by real-time RT-PCR. Tumors and proximal resection margins were obtained from 64 patients with esophageal squamous cell carcinoma from a region of high incidence in China. Methylation was assessed by melt curve analysis and expression by immunohistochemistry.RESULTS: Methylation in one of the three promoter regions assessed correlated with gene silencing in esophageal cell lines. A degree of methylation of TIMP3 was found in only four esophageal squamous cell carcinomas, and partial loss of TIMP3 protein expression in just one.CONCLUSION: Methylation and loss of expression of TIMP3 occurs infrequently in esophageal squamous cell carcinoma in a region of high incidence in China. | Eric Smith Neville J De Young Zi-Qiang Tian Maria Caruso Andrew R Ruszkiewicz Jun-Feng Liu Glyn G Jamieson Paul A Drew | 2008 | World Journal of Gastroenterology2008，14，2： | 2 |
| 3 | Quantification of Listeria monoeytogenes in minimally processed leafy vegetables using a combined method based on enrichment and 16SrRNAreal-time PCR显示文摘 | Maria A O Eliana G R Alzira M B | 2010 | Food Microbiology2010，，27： | 1 |
| 4 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 5 | A sliding manifold approach for vibration reduction of flexible systems显示文摘 | Cavallo A de Maria G Setola R | 1999 | Automatica1999，35，10： | 1 |
| 6 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 7 | Sulfide measurements by flow injection analysis and ion chromatography with electrochemical detection 显示文摘 | Innoeenzo G C Maria R G Elio D | 2000 | Analytica Chimica Acta2000，409，： | 1 |
| 8 | Development of a biosensor microarray towards food screening using imaging surface plasmon resonance 显示文摘 | SABINA R R MARIA G B GIESBERS M | 2008 | Biosensors and Bioelectronics2008，24，： | 1 |
| 9 | Screening analysis of beer ageing using near infrared spectroscopy and the successive projections algorithm for variable selection显示文摘 | MAHDI G V SEYED S M MARIA L R M | 2012 | Talanta2012，89，1： | 1 |
| 10 | Evolution of octopod sperm Ⅰ:Comparison of nuclear morphogenesis in Eledone and Octopus显示文摘 | PEPITA G B ENRIC R MARIA J Z | | 0，，62： | 1 |
| 11 | NK cell increase in neonales from the preterm to the full-term period of gestation显示文摘 | Alicia P Maria D G Salvador R | 2007 | Neonatology2007，92，： | 1 |
| 12 | Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis 显示文摘 | Giordano C Stassi G De Maria R | 1997 | Science1997，275，5302： | 1 |
| 13 | Genome-wide analysis of differentially expressed genes during the early stages of tomato infection by a potyvirus显示文摘 | ALFENAS-ZERBINI P MARIA I G F(A)VARO R D | | 0，，3： | 1 |
| 14 | Improvement of the waste oil vacuum distillation recycling by continuous extraction with dense propane 显示文摘 | Jesusa R Pablo C Maria T G | 2007 | Industrial & Engineering Chemistry Research2007，46，1： | 1 |
| 15 | Regeneration of used lubricant oil by ethane extraction 显示文摘 | Jesusa R Pablo C Maria T G | 2007 | Journal of Supercritical Fluids2007，39，3： | 1 |
| 16 | Prognostic value of human telomerase reverse transcriptase gene expression in oral carcinogenesis 显示文摘 | Pannone G De Maria S Zamparese R | 2007 | Int J Oncol2007，30，6： | 1 |
| 17 | Potential of extra cellular enzymes in remediation of polluted soils : a review 显示文摘 | Liliana G Maria A R | 2004 | Enzyme and Microbial Technology2004，35，4： | 1 |
| 18 | Attention-deficit hyperactivity disorder(ADHD) and glial integrity:S100B,cytokines and kynurenine metabolism-ef- fects of medication显示文摘 | Robert D Oades Maria R Dauvermann Benno G Schimmel- mann | 2010 | Behavioral and Brain Functions2010，6，： | 1 |
| 19 | Urban mobility and urban form: The social and environment costs of different patterns of urban expansion 显示文摘 | Roberto C Maria C G Paolo R | 2002 | Ecological Economics2002，40，2： | 1 |
| 20 | Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis 显示文摘 | Giordano C Stassi G De Maria R | 1997 | Science1997，275，5302： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员