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| 1 | Viral evasion of DNA-stimulated innate immune responses显示文摘导出病毒的 nucleic 酸的细胞的察觉到为对病毒感染的早防卫是必要的。在最近的年里,包括周期的 GMP 安培 synthase (cGAS ) 和 gamma-interferon-inducible 蛋白质(IFI16 ) ,察觉到蛋白质的 DNA 的发现导致了房间怎么对带 DNA 染色体的到来的病原体唤起强壮的天生的有免疫力的回答的理解。发信号由 DNA 传感器刺激了取决于适配器蛋白质圈套(干扰素基因的激发器) ,到启用抗病毒的蛋白质的表示,包括类型我干扰素。便于有效感染,病毒发展了大量避免策略,指向的主人 DNA 传感器,适配器蛋白质和抄写因素。在这评论, STING 小径的导致病毒的激活上的当前的文学被介绍,我们讨论在这条抗病毒的小径指向不同的步的最近识别的病毒的避免机制。 | Maria H Christensen Sфren R Paludan | 2017 | Cellular & Molecular Immunology2017，14，1： | 4 |
| 2 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 3 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 4 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 5 | Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study显示文摘 | Nauck Michael Frid Anders Hermansen Kjeld Shah Nalini S Tankova Tsvetalina Mitha Ismail H Zdravkovic Milan Düring Maria Matthews David R | 2009 | Diabetes Care2009，，： | 2 |
| 6 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 7 | Understanding the Effects of Market Orientation and E-Marketing on Service Performance显示文摘 | Tsiotsou R H Maria V | 2011 | Marketing Intelligence & Planning2011，，2： | 1 |
| 8 | A study on reducing substrates of manganese-oxidizing peroxidases from Pleurotus eryngii and Bjerkandera adusta 显示文摘 | Annette H Francisco J R D Maria J M | 1998 | FEBS Lett1998，428，3： | 1 |
| 9 | Hydroresin dispersions: New emulsifier free binders for aqueous coatings显示文摘 | Bernhard S Maria G R Sylke H | 1995 | Prog Org Coatings1995，26，2： | 1 |
| 10 | Asynahronous development of stigmatic re- ceptivity in the pear(Pyrus communis, Rosaceae) flower显示文摘 | Javier S Pilar R Maria H | 2003 | American Journal of Botany2003，90，1： | 1 |
| 11 | Electron absorption spectrum of nitrate ion and boron trihalides显示文摘 | Maria H J McDonald J R McGlynn S P | 1973 | Am Chem Soc1973，95，4： | 1 |
| 12 | Transfer of quinolone resistance gene qnrA1 to Escherichia coli through a 50 kb conjugative plasmid resulting from the splitting of a 300 kb plasmid显示文摘 | Ulises G R Humberto B Maria Jose H V | 2012 | Antimicrob Chemother2012，67，7： | 1 |
| 13 | Polyphosphate kinase 1, a conserved bacterial enzyme in a eukaryote Dictyostelium discoideum with a role in cytokinesis显示文摘 | ZHANG H MARIA R Gomez-Garcia | 2007 | Proc Natl Acad Sci U S A2007，104，16： | 1 |
| 14 | Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signaling 显示文摘 | Barbel S Johanna R Maria H | 2009 | Biochem J2009，421，： | 1 |
| 15 | Efficacy and safety of valsartan compared with enalapril at different altitudes显示文摘 | Botero R Matiz H Maria E | 2000 | Int J Cardiol2000，72，3： | 1 |
| 16 | Microbial degradation of the benzonitrile herbicides dichlobenil, bromoxynil and ioxynil in soil and subsurface environments-Insights into degradation pathways, persistent metabolites and involved degrader organisms显示文摘 | Maria S H Sebastian R S Jan S | 2008 | Environmental Pollution2008，154，： | 1 |
| 17 | Human endothelial cells express CCR2 and respond to MCP-1:direct role of MCP-1 in angiogenesis and tumor progression显示文摘 | Maria L P Young H A | 2000 | Blood2000，96，1： | 1 |
| 18 | Evaluation of fungal burden and aflatoxin presence in packed medicinal plants treated by gamma radiation显示文摘 | SIMONE A EDLAYNE G MARIA H R | 2010 | J Food Protect2010，73，5： | 1 |
| 19 | Neolignans, styrylpyrones and flavonoids from an Aniba species 显示文摘 | Maria H R Massayoshi Y Jose G S M | 1997 | Phytochemistry1997，45，6： | 1 |
| 20 | A kinetic model for methanol conversion to hydrocarabons显示文摘 | Mihail R Straja S Maria G H etal | 1983 | Chem Eng Sci1983，38，9： | 1 |
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