|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Alterations in the function of circulating mononuclear cells derived from patients with Crohn’s disease treated with mastic显示文摘AIM: To assess the effects of mastic administration on cytokine production of circulating mononuclear cells of patients with active Crohn's disease (CD). METHODS: The study was conducted in patients with established mildly to moderately active CD, attending the outpatient clinics of the hospital, and in healthy controls. Recruited to a 4 wk treatment with mastic caps (6 caps/d, 0.37 g/cap) were 10 patients and 8 controls, all of who successfully completed the protocol. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), macrophage migration inhibitory factor (MIF) and intracellular antioxidant glutathione (GSH) were evaluated in peripheral blood mononuclear cells (PBMC) before and after treatment. RESULTS: Treating CD patients with mastic resulted in the reduction of TNF-α secretion (2.1 ± 0.9 ng/mL vs 0.5 ± 0.4 ng/mL, P = 0.028). MIF release was signif icantly increased (1.2 ± 0.4 ng/mL vs 2.5 ± 0.7 ng/mL, P = 0.026) meaning that random migration and chemotaxis of monocytes/macrophages was inhibited. No signifi cant changes were observed in IL-6, MCP-1 and GSH concentrations. CONCLUSION: This study shows that mastic acts as an immunomodulator on PBMC, acting as a TNF-α inhibitor and a MIF stimulator. Although further double-blind, placebo-controlled studies in a large number of patients is required to clarify the role of this natural product, this f inding provides strong evidence that mastic might be an important regulator of immunity in CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantaf illidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 3 | Apparent diffusion coefficient values of normal testis and variations with age显示文摘在阴囊的病理的评估的散开加权的磁性的回声成像(DWI ) 的实用性最近被报导了。当解释正常阴囊的解剖和病理时,阴囊的明显的散开系数(模数转换器) 珍视的正常和他们有年龄的变化的一本标准参考书是必要的。我们用 DWI 评估了 147 个正常睾丸,包括从 20-39 年(组 1 ) 的 53 个人的 71 个睾丸,从 40-69 年(组 2 ) 的 42 个人的 67 个睾丸和从比 70 年(组 3 ) 老的六个人的九个睾丸。DWI 沿着轴的飞机被执行,用单个射击, multislice 纺纱回响平面散开脉搏顺序和 0 和 900 s 公里 −2 的 b 值。正常阴囊的实质的模数转换器价值的平均数和标准差独立为每个年龄组被计算。柱子 hoc 分析(Dunnett T3 ) 跟随的变化(ANOVA ) 的分析被用于统计目的。模数转换器价值(×正常阴囊的织物的 10 −3 公里 2 s −1) 在年龄组之中是不同的(组 1:1.08 ±0.13;组 2:1.15 ±0.15 和组 3:1.31 ±0.22 ) 。ANOVA 在年龄组之中在吝啬的模数转换器揭示了差别(F = 11.391, P <0.001 ) 。波斯特 hoc 分析显示出组之间的差别 1 和 2 (P = 0.008 ) 并且在组之间 1 和 3 (P = 0.043 ) ,然而并非在组之间 2 和 3 (P = 0.197 ) 。我们的调查结果建议正常阴囊的织物的模数转换器价值与推进年龄增加。 | Athina C Tsili Dimitrios Giannakis Anastasios Sylakos Alexandra Ntorkou Loukas G Astrakas Nikolaos Sofikitis Maria I Argyropoulou | 2014 | Asian Journal of Andrology2014，16，3： | 8 |
| 4 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 5 | Chios mastic treatment of patients with active Crohn's disease显示文摘AIM: To evaluate the effectiveness of mastic administra-tion on the clinical course and plasma inflammatory me-diators of patients with active Crohn’s disease (CD).METHODS: This pilot study was conducted in patients with established mild to moderately active CD, attend-ing the outpatient clinics of the hospital, and in healthy controls. Ten patients and 8 controls were recruited for a 4-wk treatment with mastic caps (6 caps/d, 0.37 g/cap). All patients successfully completed the protocol. CD Ac-tivity Index (CDAI), Nutritional Risk Index (NRI), C-re-active protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), monocyte chemotactic protein-1 (MCP-1), and total antioxidant potential (TAP) were evaluated in the plasma at baseline and at the end of the treatment period. Results were expressed as mean values ± SE and P < 0.05 was considered to indicate statistical significance.RESULTS: Patients exhibited significant reduction of CDAI (222.9 ± 18.7 vs 136.3 ± 12.3, P = 0.05) as com-pared to pretreament values. Plasma IL-6 was signifi-cantly decreased (21.2 ± 9.3 pg/mL vs 7.2 ± 2.8 pg/ mL, P = 0.027), and so did CRP (40.3 ± 13.1 mg/mL vs 19.7 ± 5.5, P = 0.028). TAP was significantly increased (0.15 ± 0.09 vs 0.57 ± 0.15 mmol/L uric acid, P = 0.036). No patient or control exhibited any kind of side effects. CONCLUSION: The results suggest that mastic signifi-cantly decreased the activity index and the plasma levels of IL-6 and CRP in patients with mildly to moderately ac-tive CD. Further double-blind, placebo-controlled studies in a larger number of patients are required to clarify the role of this natural product in the treatment of patients with CD. | Andriana C Kaliora Maria G Stathopoulou John K Triantafillidis George VZ Dedoussis Nikolaos K Andrikopoulos | 2007 | World Journal of Gastroenterology2007，13，5： | 7 |
| 6 | Surgical treatmemt of primary supratentorial intracerebral hemorrhage in stuporous and comatose patiemt显示文摘 | Maria G Anile C Colosimo C | | 0，，01： | 1 |
| 7 | Effect of transport time on sensorial aspects of beef meat quality显示文摘 | Villarroel M Maria G A Safiudo C | 2003 | Meat Science2003，63，3： | 1 |
| 8 | Sulfide measurements by flow injection analysis and ion chromatography with electrochemical detection 显示文摘 | Innoeenzo G C Maria R G Elio D | 2000 | Analytica Chimica Acta2000，409，： | 1 |
| 9 | Determination of Tryptophan by High-performance Liquid Chromatography of Alkaline Hydrolysates With Spectrophotometric Detection 显示文摘 | Maria M Y Justo P Julio G C etal | 2004 | Food Chemistry(S0308-8146)2004，85，2： | 1 |
| 10 | Characterization and remediation of soils contaminated with uranium显示文摘 | MARIA G LUCIAN V P IGOR C | 2009 | Journal of Hazardous Materi- als2009，163，： | 1 |
| 11 | Mandarin peel wastespretreatment with steam explosion for bioethanol production显示文摘 | MARIA B A LIDIA G V FAYINY P G C | 2010 | Bioresource Technology2010，101，10： | 1 |
| 12 | Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis 显示文摘 | Giordano C Stassi G De Maria R | 1997 | Science1997，275，5302： | 1 |
| 13 | Formation of polymeric nano - emulsions by a low - energy method and their use tbr nanopar-ticle preparation显示文摘 | GABRIELA C MARIA J G SOLANS C | 2011 | Journal of Colloid and Interface Science2011，353，： | 1 |
| 14 | Improvement of the waste oil vacuum distillation recycling by continuous extraction with dense propane 显示文摘 | Jesusa R Pablo C Maria T G | 2007 | Industrial & Engineering Chemistry Research2007，46，1： | 1 |
| 15 | Regeneration of used lubricant oil by ethane extraction 显示文摘 | Jesusa R Pablo C Maria T G | 2007 | Journal of Supercritical Fluids2007，39，3： | 1 |
| 16 | Characterization of acetic acid bacteria in“traditional balsamic vinegar”显示文摘 | MARIA G CINZIA C LUCIANA D V | 2006 | International Journal of Food Microbiology2006，106，2： | 1 |
| 17 | Urban mobility and urban form: The social and environment costs of different patterns of urban expansion 显示文摘 | Roberto C Maria C G Paolo R | 2002 | Ecological Economics2002，40，2： | 1 |
| 18 | Enzyme-based bioartificial polymeric materials: the α-amylase-poly(vinyl alcohol) system 显示文摘 | Caterina C Luigi L Maria G | 1997 | Polymer International1997，44，： | 1 |
| 19 | Neuroanatomical corre- lates of category-specific semantic disorders: a critical suney 显示文摘 | Gainotti G Silveri Maria C | 1995 | Memory1995，3，34： | 1 |
| 20 | Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis 显示文摘 | Giordano C Stassi G De Maria R | 1997 | Science1997，275，5302： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员