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| 1 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 2 | All solid-state high power mi- crowave source with high repetition frequency显示文摘 | Bragg J Sullivan W Manch D | 2013 | Review of Scientific Instruments2013，84，05： | 1 |
| 3 | HIV-activated human plas- macytoid DCs induce Tregs through an indoleamine 2,3-dioxygen- /tse-dependent mechanism 显示文摘 | Manches O Mann D Fallahi A | 2008 | J Clin Invest2008，118，10： | 1 |
| 4 | HIV-activated hu- man plasmacytoid DCs induce Tregs through an indoleamine 2, 3-dioxygenase-dependent mechanism 显示文摘 | Manches O Munn D Fallahi A | 2008 | J Clin Invest2008，118，10： | 1 |
| 5 | Two-year results of conductive keratoplasty for the correction of low to moderate hyperopia显示文摘 | Lin D Y Manche E E | 2003 | J Cataract Refract Surg2003，29，12： | 1 |
| 6 | HlV-activated hu- man plasmacytoid DCs induce Tregs through an indoleamine 2, 3-dioxygenase-dcpendent mechanism 显示文摘 | Manches O Munn D Fallahi A | 2008 | J Clin Invest2008，118，10： | 1 |
| 7 | HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2,3-dioxygenase- dependent mechanism 显示文摘 | Manches O Munn D Fallahi A Lifson J Chaperot L Plumas J Bhardwai N | 2008 | J Clin Invest2008，118，10： | 1 |
| 8 | TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity 显示文摘 | Bogunovic D Manches O Godefroy E | 2011 | Cancer Res2011，71，16： | 1 |
| 9 | Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNAinteractions显示文摘 | Beignon A S Mckenna K Skoberne M Manches O DaSilva I Kavanagh D G Larsson M Gorelick R J Lif- son J D Bhardwaj N | 2005 | J Clin Invest2005，115，： | 1 |
| 10 | Custom-contoured ablation pattern method for the treatment of decentered laser ablations显示文摘 | LIN D Y MANCHE E E | 2004 | J Cataract Refract Surg2004，30，8： | 1 |
| 11 | HIV-activated human plasmacy- toid DCs induce Tregs through an indoleamine 2,3-dioxygenase-de- pendent mechanism显示文摘 | Manches O Munn D Fallahi A | 2008 | J Clin Invest2008，118，10： | 1 |
| 12 | Steroid-in- duced glaucoma after laser in situ keratomileusis associat- ed with interface fluid显示文摘 | Hamilton D R Manche E E Rich L F | 2002 | Ophthalmol2002，109，4： | 1 |
| 13 | HIV-activated hu- man plasmacytoid DCs induce Tregs through an indoleamine 2, 3- dioxygenasedependent mechanism显示文摘 | MANCHES O MUNN D FALLAHI A | 2008 | J Clin Invest2008，118，10： | 1 |
| 14 | Endocytosis of HIV-1 activates plasmaey toid dendritic cells via Toll-like receptor-viral RNA interactions 显示文摘 | Beignon A S Mckenna K Skobene M Manches O DaSilva I Kavanagh D G | 2005 | J Clin Invest2005，115，： | 1 |
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