|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 青藏高原羌塘中部蓝片岩的地球化学特征及其构造意义显示文摘青藏高原羌塘中部的冈玛日 -桃形错地区蓝片岩被认为是板块构造边界的产物 ,通过对其主量元素、微量元素和稀土元素的地球化学特征的综合研究 ,其原岩属于洋岛型碱性玄武岩。再结合该地区的地质研究 ,表明在该地区存在一个古特提斯洋 。 | 邓希光 丁林 刘小汉 An Yin Paul A KAPP Michael A MURPHY Craig E MANNING | 2002 | 岩石学报2002，18，4： | 58 |
| 2 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 3 | Logistics outsourcing relationships:Customer perspectives显示文摘 | A Michael Knemeyer Thomas M Corsi and Paul R Murphy | 2003 | Journal of Business Logistics2003，24，1： | 1 |
| 4 | Evaluating the Performance of Third-Parth Logistics Arrangements:A Relationship Marketing Perspective显示文摘 | A Michael Knemeyer Paul R Murphy | 2004 | Journal of Supply Chain Management2004，40，1： | 1 |
| 5 | Measurements of protein carbonyls, ortho - and meta -tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats显示文摘 | Stefan M.K Davies Anne Poljak Mark W Duncan George A Smythe Michael P Murphy | 2001 | Free Radical Biology and Medicine2001，，2： | 1 |
| 6 | Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial显示文摘 | Gilles Montalescot Stephen D Wiviott Eugene Braunwald Sabina A Murphy C Michael Gibson Carolyn H McCabe Elliott M Antman | 2009 | The Lancet . 2009 (9665)2009，，9665： | 1 |
| 7 | Evaluating the performance of third-party logistics arrangements: a relationship marketing perspective显示文摘 | A Michael Knemeyer Paul R Murphy | 2004 | Journal of Supply Chain Management2004，40，1： | 1 |
| 8 | Neuropsy- chological impairment in patients with major depressive disorder:the effects of feedback on task performance显示文摘 | Murphy F C Michael A Robbins T W | 2003 | Psychological medicine2003，33，3： | 1 |
| 9 | Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial显示文摘 | Gilles Montalescot Stephen D Wiviott Eugene Braunwald Sabina A Murphy C Michael Gibson Carolyn H McCabe Elliott M Antman | 2009 | The Lancet2009，，9665： | 1 |
| 10 | High quality genomic DNA extraction from large milk samples显示文摘 | Michael A Murphy Mohammad Reza Shariflou and Chris Moran | 2002 | Journal of Dairy Research2002，，69： | 1 |
| 11 | Mesozoic and Cenozoic tectonic evolution of the Shiquanhe area of western Tibet显示文摘 | Paul Kapp Michael A Murphy An Yin | 2003 | Tectonic2003，22，4： | 1 |
| 12 | Tomographic evidence for wholesale underthrusting of India beneath the entire Tibetan plateau显示文摘 | Zhou Hua-wei Michael A Murphy | 2005 | Journal of Asian Earth Sciences2005，25，3： | 1 |
| 13 | 普拉格雷与氯吡格雷用于拟行PCI的ST段抬高型心肌梗死患者的比较(TRITON—TIMI38):一项双盲、随机对照研究显示文摘背景对ST段抬高型心肌梗死(STEMI)患者进行采用支架的机械再灌注治疗,需要辅以阿司匹林和氯吡格雷的二联抗血小板治疗。普拉格雷是一种起效迅速的强效噻吩吡啶类药物,是氯吡格雷以外的另一种选择。本研究旨在比较拟行PCI治疗的STEMI患者应用普拉格雷与氯吡格雷的效果。方法此项双盲、随机对照研究在30个国家的707个中心进行。利用交互式语音应答系统将3534例STEMI患者随机分为两组,服用普拉格雷(负荷剂量60mg,维持剂量10mg;n=1769)或氯吡格雷(负荷剂量300mg,维持剂量75mg;n=1765)。医患双方均不了解分组情况。主要终点事件是心血管性死亡、非致死性心肌梗死或非致死性卒中。采用意向治疗方法进行疗效分析。随访15个月,在30d时进行次级分析。此研究已在Clinical Trials.gov注册,注册号为NCT00097591。结果在30d时,普拉格雷组和氯吡格雷组中出现主要终点事件的患者数分别为115例(6.5%)和166例(9.5%)(HR0.68,95%CI0.54~0.87;P=0.0017)。这一相对效果持续到15个月时[174例(10.0%)US216例(12.4%);HR0.79,95%C10.65~0.97;P:0.0221]。30d时,普拉格雷组的主要次级终点事件(心血管性死亡、心肌梗死或紧急靶血管血运重建)发生率明显较低(HR0.75,95%C10.59~0.96:P=0.0205),15个月时同样如此(HR0.79,95%C10.65—0.97;P=0.0250);普拉格雷组的支架血栓形成也明显减少。与冠状动脉搭桥(CABG)手术无关的心肌梗死溶栓(TIMI)严重出血事件,两组之间在30d(P=0.3359)和15个月(P=0.6451)时无明显差异。危及生命的TIMI严重出血以及TIMI严重或轻微出血的情况在两组间相似:普拉格雷组仅见CABG术后的TIMI严重出血显著增加(P=0.0033)。结论在拟行PCI治疗的STEMI患者中,与氯吡格雷相比,普拉格雷能更有效地预防缺血事件,而且出血风险并无明显增加。 | Gilles Montalescot Stephen D Wiviott Eugene Braunwald Sabina A Murphy C Michael Gibson Carolyn H McCabe Elliott M Antman 王海玲(译) 贾宁(译) 韩常宝(审校) | 2009 | 世界临床医学2009，，9： | 1 |
| 14 | Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial显示文摘 | James Shepherd Gerard J Blauw Michael B Murphy Edward LEM Bollen Brendan M Buckley Stuart M Cobbe Ian Ford Allan Gaw Michael Hyland J Wouter Jukema Adriaan M Kamper Peter W Macfarlane A Edo Meinders John Norrie Chris J Packard Ivan J Perry David J Stott B | 2002 | 2002 (9346)2002，，9346： | 1 |
| 15 | Logistics outsourcing relationships:Customer perspectives显示文摘 | A Michael Knemeyer Thomas M Corsi Paul R Murphy | 2003 | Journal of Business Logistics2003，24，1： | 1 |
| 16 | Mesozoic and Cenozoic tectonic evolution of the Shiquanhe area of western Tibet显示文摘 | PAUL Kapp MICHAEL A Murphy AN Yin | 2003 | Tectonic2003，22，4： | 1 |
| 17 | Methods for improving colorectal cancer annotation efficiency for artificial intelligence-observer training显示文摘BACKGROUND Missing occult cancer lesions accounts for the most diagnostic errors in retrospective radiology reviews as early cancer can be small or subtle,making the lesions difficult to detect.Secondobserver is the most effective technique for reducing these events and can be economically implemented with the advent of artificial intelligence(AI).AIM To achieve appropriate AI model training,a large annotated dataset is necessary to train the AI models.Our goal in this research is to compare two methods for decreasing the annotation time to establish ground truth:Skip-slice annotation and AI-initiated annotation.METHODS We developed a 2D U-Net as an AI second observer for detecting colorectal cancer(CRC)and an ensemble of 5 differently initiated 2D U-Net for ensemble technique.Each model was trained with 51 cases of annotated CRC computed tomography of the abdomen and pelvis,tested with 7 cases,and validated with 20 cases from The Cancer Imaging Archive cases.The sensitivity,false positives per case,and estimated Dice coefficient were obtained for each method of training.We compared the two methods of annotations and the time reduction associated with the technique.The time differences were tested using Friedman’s two-way analysis of variance.RESULTS Sparse annotation significantly reduces the time for annotation particularly skipping 2 slices at a time(P<0.001).Reduction of up to 2/3 of the annotation does not reduce AI model sensitivity or false positives per case.Although initializing human annotation with AI reduces the annotation time,the reduction is minimal,even when using an ensemble AI to decrease false positives.CONCLUSION Our data support the sparse annotation technique as an efficient technique for reducing the time needed to establish the ground truth. | Matthew Grudza Brandon Salinel Sarah Zeien Matthew Murphy Jake Adkins Corey T Jensen Curtis Bay Vikram Kodibagkar Phillip Koo Tomislav Dragovich Michael A Choti Madappa Kundranda Tanveer Syeda-Mahmood Hong-Zhi Wang John Chang | 2023 | World Journal of Radiology2023，15，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员