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| 1 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 2 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 3 | Scalable microfabrication of three-dimensional porous interconnected graphene scaffolds with carbon spheres for high-performance all carbon-based micro-supercapacitors显示文摘As one of the most important micro energy storage devices(MESDs),graphene-based micro-supercapacitors(G-MSCs)possess the advantages of excellent flexibility,long cycle life,affordability and high reliability.In most cases,constructing three-dimensional(3D)graphene networks is widely utilized to promote the permeation of electrolyte and enhance the utilization of active materials.In this work,conventional freeze-drying process is utilized in the fabrication of G-MSCs to constitute 3D interconnected networks micro-electrodes,and further by regulating the composition of inks,carbon spheres(CSs)at different mass loadings are introduced into the graphene scaffolds to further increase the active sites of the micro-electrodes.The fabricated all carbon-based MSC with the optimal mass loading of CSs(0.406 mg cm^(-2))exhibits a high specific areal capacitance of 17.01mF cm^(-2)at the scan rate of 10mV s^(-1)and a capacitance retention of 93.14%after 10000 cycles at the scan rate of 500 mV s^(-1).The proposed microfabrication process is facile and fully compatible with modern microtechnologies and will be highly suitable for large-scale production and integration. | Yiming Chen Minghao Guo Liang He Wei Yang Lin Xu Jiashen Meng Xiaocong Tian Xinyu Ma Qiang Yu Kaichun Yang Xufeng Hong Liqiang Mai | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 4 | The analysis of electrical performances of nanowires silicon solar cells显示文摘A theoretical model of silicon solar cells with ultra-small textured surface has been established based on depletion approximation and drift diffusion theory. The ultra-small textured surface achieves the low reflectance by multiple reflections among the silicon nanowires(NWs) . The electrical performances of the solar cells,including open circuit voltage(Voc),short circuit current(Isc) and conversion efficiency(η),are analyzed by the theoretical model. The results show that the low reflectance is not the only pursuit in manufacturing the Si NWs solar cells. Other factors including optimizing the surface passivation,improving the silicon wafers quality and designing the proper nanowire length should be considered together with NWs structure. | LI HaoFeng JIA Rui DING WuChang CHEN Chen MENG YanLong LIU XinYu | 2011 | Science China(Technological Sciences)2011，54，12： | 4 |
| 5 | LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM)is a common complication in diabetic patients.The molecular mechanisms of DCM remain to be fully elucidated.The intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac regeneration.In this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular mechanisms.The expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes.Knockout of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM mice.Overexpression of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose.Lnc DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts.In addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in cardiomyocytes.In summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts.Inhibition of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy. | Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang | 2022 | Science China(Life Sciences)2022，65，6： | 4 |
| 6 | Multifunctional aramid nanofibers reinforced RGO aerogels integrated with high-efciency microwave absorption, sound absorption and heat insulation performance显示文摘Although lightweight and three-dimensional(3 D) graphene aerogels are highly desirable for microwave absorption(MA) due to their high porosity,specific surface area,and 3 D conductive network,it still remains a large challenge to construct a multifunctional application framework to quickly adapt to the complex practical environment,making it to be efficiently applied in a variety of complex situation.Herein,multifunctional aramid nanofibers(ANFs) reinforced reduced graphene oxide aerogels(RGO@ANF) have been achieved by in-situ gel reaction,freeze-drying,and thermal annealing processes.The introduced ANFs in RGO aerogels can prevent the graphene sheets from over-stacking and enhance the connectivity of cell walls,thus leading to excellent compression resistance,MA,sound absorption,and thermal insulation performance.Under 70% strain,the maximum compressive stress of RGO@ANF aerogel reaches78.8 kPa,and reversible compressibility with reliable resistance to fatigue for 100 compressive cycles at20% strain.Further,the RGO@ANF aerogel exhibit a minimum reflection loss(RL_(min)) of-56.5 dB and a maximum effective absorption bandwidth(EAB) of 7.0 GHz at a thickness of 2.8 mm,basically covering the X and Ku bands.Moreover,the hybrid aerogel exhibited excellent sound absorption with an average absorption coefficient> 0.56 at 2-6 kHz and good thermal insulation performance with low thermal conductivity of about 49.18 mW m-1K-1.The integrated graphene aerogels with such multifunctional performances hold a great promise for applications such as MA,sound absorption,and heat insulation. | Qian Liu Liang Tang Jinzhe Li Yao Chen Zhengkang Xu Jiatong Li Xinyu Chen Fanbin Meng | 2022 | Journal of Materials Science & Technology2022，，35： | 4 |
| 7 | Blockchain and MEC-Assisted Reliable Billing Data Transmission over Electric Vehicular Network:An Actor–Critic RL Approach显示文摘Recently,electric vehicles(EVs)have been widely used under the call of green travel and environmental protection,and diverse requirements for charging are also increasing gradually.In order to ensure the authenticity and privacy of charging information interaction,blockchain technology is proposed and applied in charging station billing systems.However,there are some issues in blockchain itself,including lower computing efficiency of the nodes and higher energy consumption in the consensus process.To handle the above issues,in this paper,combining blockchain and mobile edge computing(MEC),we develop a reliable billing data transmission scheme to improve the computing capacity of nodes and reduce the energy consumption of the consensus process.By jointly optimizing the primary and replica nodes offloading decisions,block size and block interval,the transaction throughput of the blockchain system is maximized,as well as the latency and energy consumption of the system are minimized.Moreover,we formulate the joint optimization problem as a Markov decision process(MDP).To tackle the dynamic and continuity of the system state,the reinforcement learning(RL)is introduced to solve the MDP problem.Finally,simulation results demonstrate that the performance improvement of the proposed scheme through comparison with other existing schemes. | Xinyu Ye Meng Li Pengbo Si Ruizhe Yang Enchang Sun Yanhua Zhang | 2021 | China Communications2021，18，8： | 3 |
| 8 | Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice显示文摘亲爱的编辑, | Dekun Wang Qingwen Meng Lihong Huo Meng Yang Lingling Wang Xinyu Chen JianchaoWang Zhiguo Li Xiaoying Ye Na Liu Qiuyan Li Zhen Dai Hongsheng Ouyang Ning Li Jun Zhou Lingyi Chen Lin Liu | 2015 | Protein & Cell2015，6，2： | 3 |
| 9 | Microfluidic-enabled ambient-temperature synthesis of ultrasmall bimetallic nanoparticles显示文摘The production of bimetallic nanoparticles with ultrasmall sizes is the constant pursuit in chemistry and materials science because of their promising applications in catalysis,electronics and sensing.Here we report ambient-temperature preparation of bimetallic NPs with tunable size and composition using microfluidic-controlled co-reduction of two metal precursors on silicon surface.Instead of free diffusion of metal ions in bulk system,microfluidic flow could well control the local ions concentration,thus leading to homogenous and controllable reduction rate among different nucleation sites.By controlling precursor concentration,flow rate and reaction time,we rationally design a series of bimetallic NPs including Ag-Cu,Ag-Pd,Cu-Pt,Cu-Pd and Pt-Pd NPs with ultrasmall sizes(~3.0 nm),tight size distributions(relative standard deviation(RSD)<21%),clean surface,and homogenous elemental compositions among particles(standard deviation(SD)of weight ratios<3.5%).This approach provides a facile,green and scalable method toward the synthesis of diverse bimetallic NPs with excellent activity. | Huayi Shi Bin Song Runzhi Chen Qiang Zhang Guyue Hu Jing Li Jinhua Wang Xinyu Meng Houyu Wang Yao He | 2022 | Nano Research2022，15，1： | 2 |
| 10 | Research on ultra-small textured surface of multicrystalline silicon solar cell显示文摘The ultra-small textured surface of multicrystalline silicon solar cell,prepared by electroless chemical-etching method,shows an excellent anti-reflection property over a wide spectral bandwidth.A novel back surface protection method and front surface passivation method have been used in the multicrystalline solar cells with ultra-small textured surfaces.With these improvements,the back surface remains intact after the etch process and the efficient minority lifetime is apparently increased.The test result shows that the solar cell with ultra-small textured surface can obtain better electrical performances by these improvements. | LI HaoFeng JIA Rui DOU BingFei CHEN Chen XING Zhao YANG YongZhou DING WuChang MENG YanLong LIU XinYu YE TianChun LI ShangQing | 2013 | Science China(Technological Sciences)2013，56，4： | 2 |
| 11 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 12 | Experimental studies on ozonation of ethylenethiourea显示文摘The experimental study on ozonation of ethylenethiourea(ETU) is conducted.The reaction of gas-phase ETU with 0.63 × 10-6 mol/L ozone is carried out in a 200-L reaction chamber.The secondary organic aerosol(SOA) resulted from the ozonation of gas-phase ETU is observed with a scanning mobility particle size(SMPS).The rapid exponential growth of SOA reveals that the atmospheric lifetime of ETU vapor towards ozone reaction is less than four days.The ozonation of dry ETU particles,ETU-contained water droplets and ETU aqueous solution is investigated with a vacuum ultraviolet photoionization aerosol time-of-flight mass spectrometer(VUVATOFMS).The formation of 2-imidazoline is observed in the ozonation of dry ETU particles and ETU-contained water droplets.The formation of 2-imidazoline and ethylenerea is observed in the ozonation of ETU aqueous solution. | Xinyu Dong Junwang Meng Bo Yang Yang Zhang Jie Gan XiShu Jinian Shu | 2011 | Journal of Environmental Sciences2011，23，1： | 2 |
| 13 | Improvement in the Oxidation Resistance of Tungsten by Sol-Gel Derived Al_2O_3 Coating显示文摘An Al2O3 coating was prepared from aluminum isopropoxide as precursor on tungsten substrate.The dependences of crystalline and phase in Al2O3 coating on temperature were studied.The results show the coatings being compact,uniform and crack-free can be obtained by suitable experiment.The main phase of coating is α-Al2O3.Compared to the uncoated specimens,the ones with coatings synthesized by sol-gel process provide excellent oxidation resistance at high temperature. | Fan Ailing1,Meng Lingsheng1,Huang Lang1,2,Ma Jie1 1 College of Materials Science and Engineering,Beijing University of Technology,Beijing 100124,China 2 Department of Safety and Environment,Xinyu Iron&Steel Group Co.Ltd,Xinyu 338001,China | 2012 | 稀有金属材料与工程2012，41，S1： | 2 |
| 14 | In vitro corrosion resistance and cytocompatibility of nano-hydroxyapatite reinforced Mg–Zn–Zr composites显示文摘 | Xinyu Ye Minfang Chen Meng Yang Jun Wei Debao Liu | 2010 | Journal of Materials Science: Materials in Medicine2010，，4： | 2 |
| 15 | Peripheral blood indices to predict PFS/OS with anlotinib as a subsequent treatment in advanced small-cell lung cancer显示文摘Objective:In the phase II ALTER-1202(NCT03059797)trial,anlotinib significantly improved progression-free survival(PFS)and overall survival(OS)in patients with advanced small-cell lung cancer(SCLC)who underwent at least 2 previous chemotherapy cycles,when compared with a placebo group.To identify potential factors for predicting efficacy and prognosis with anlotinib treatment,we analyzed hematological indices at baseline and adverse events(AEs)over the course of anlotinib treatment.Methods:Data were collected from March 2017 to April 2019 from a randomized,double-blind,placebo-controlled,multicenter,phase II trial of anlotinib.Eligible patients were randomly assigned 2:1 to receive anlotinib or placebo until disease progression,intolerable toxicity,or withdrawal of consent.The patients received anlotinib(12 mg)or an analogue capsule(placebo)orally once daily for 14 days every 3 weeks.The hematological indices at baseline and AEs that occurred in the initial 2 treatment cycles were recorded.The Kaplan-Meier test and Cox regression model were used to assess survival differences.Results:A total of 82 patients(81 patients with complete data)were randomly assigned to receive anlotinib,with 38 receiving a placebo as a control.Multivariate analysis indicated that an elevated neutrophil to lymphocyte ratio>7.75 and lactate dehydrogenase>254.65 U/L at baseline were independent risk factors for PFS;basal elevated aspartate aminotransferase>26.75 U/L,neuron specific enolase>18.64 ng/mL,and fibrinogen>4.645 g/L were independent risk factors for OS.During treatment,elevatedγglutamyltransferase and hypophosphatemia were independent predictors for a poor PFS,and elevatedγ-glutamyl transferase and hypercholesterolemia were independent factors for OS.Conclusions:Our study preliminarily defined potential factors that affected the PFS and OS at baseline and during anlotinib treatment in patients with advanced SCLC.Our findings provide a basis for screening the dominant population and for dynamic efficacy monitoring with anlotinib therapy. | Cuicui Zhang Jing Wang Xinyue Wang Zhaoting Meng Ying Cheng Kai Li | 2022 | Cancer Biology & Medicine2022，19，8： | 1 |
| 16 | In vitro corrosion resistance and cytocompatibility of nano-hydroxyapatite reinforced Mg–Zn–Zr composites显示文摘 | Xinyu Ye Minfang Chen Meng Yang Jun Wei Debao Liu | 2010 | Journal of Materials Science: Materials in Medicine2010，，4： | 1 |
| 17 | In vitro corrosion resistance and cytocompatibility of nano-hydroxyapatite reinforced Mg-Zn-Zr alloy composite显示文摘 | Ye Xinyu Chen Minfang Yang Meng | 2010 | Journal of Material Science:Material in Medicine2010，21，4： | 1 |
| 18 | Progress and Understanding on Catalysts with Well-defined Interface for Boosting CO_(2)Conversion显示文摘Catalytic conversion of CO_(2)into valuable chemicals like CH;OH is the most promising way to alleviate CO_(2)emission for solving the serious climate change issue.Multi-component catalysts with well-defined interface show outstanding performance in CO_(2)conversion due to the synergistic effects and multifunctional properties caused by the well-defined interface.A discharge technique,named as cold plasma,has been recognized as an excellent strategy for tuning catalyst interface properties.The temperature of cold plasma is lower than 200℃,and can be further lowered to room temperature by simply changing the operation conditions of cold plasma.The lower temperature of cold plasma can well maintain the catalyst structures,especially the porous structures.When conducting cold plasma,in addition to nontoxic working gases like Ar and air,no harmful substances are used.Cold-plasma-prepared catalysts have unique interface properties,and thereby exhibit superior performance in CO_(2)conversion over the catalysts prepared by traditional methods.The present review summarizes the progress about the cold-plasma-prepared catalysts for CO_(2)conversion,discusses the origin for the outstanding catalytic performance,and proposes the challenges and opportunities for further studies.This will stimulate more deep insights into the cold-plasma-prepared catalysts with well-defined interface properties for achieving more efficient CO_(2)conversion. | Binran Zhao Yiyi Zhao Peng Liu Yulong Men Xinyu Meng Yunxiang Pan | 2022 | Chinese Journal of Structural Chemistry2022，41，4： | 1 |
| 19 | Quantitative evaluation of fetal brainstem-vermis and brainstem-tentorium angles by three-dimensional ultrasound显示文摘 | Xinyue Meng Limei Xie | 2014 | Ultrasound in Medicine & Biology2014，，： | 1 |
| 20 | Environmental contribution to needle variation among natural populations of Pinus tabuliformis显示文摘Variations in the phenotypic characteristics of conifer needles is a consequence of genetic evolution that has been widely used in geographic variation and ecological studies.Although many studies are based on an in situ sampling strategy and generally realize the contribution of environmental effects to variation in needle traits,it is still uncertain which needle traits are most influenced by genetic effects and which are most influenced by the environment.Using both a common garden experiment to eliminate environmental heterogeneity and an in situ sampling strategy,we compared 18 Pinus tabuliformis needle traits among 10 geographical populations.Using both sampling strategies,we found significant differences in needle traits among populations and among individuals within populations.Differences in the‘‘among-population’’variance component between the two sampling strategies revealed the environmental contribution among natural populations for each trait.The among-population variance in the following traits exceeded 8%:needle length,number of stomata within 2 mm(NS2),number of stomatal lines on the planar side,number of resin canals(RCN)and the resin canal area(RCA).For the stability of needle traits,NS2,RCN,RCA,ratio of the vascular bundle area to the RCA(VBA/RCA),and MA/RCA differed significantly in more than five provenance changes between the common garden populations and natural populations,which may be susceptible to environmental effects.Conversely,the crosssectional area,mesophyll area(MA),MA/(VBA+RCA),and MA/VBA were phenotypically stable.Geographic variation patterns and systematic relation of needle traits differed between the two sampling strategies,suggesting that in situ sampling results may reflect environmental effects and deviate statistical parameters for genetic study.Future studies of genetic evolution in the context of geographic variation should be based on appropriate sampling strategies and stable phenotypic traits. | Jingxiang Meng Xinyu Chen Yujie Huang Liming Wang Fangqian Xing Yue Li | 2019 | Journal of Forestry Research2019，30，4： | 1 |
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