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| 1 | Jianpijiedu Fang improves survival of hepatocarcinoma mice by affecting phosphatase and tensin homolog, phosphoinositide 3-kinase, and focal adhesion kinase显示文摘OBJECTIVE: To investigate the effect of Jianpijiedu Fang (JPJDF) on phosphatase and tensin homolog (PTEN), phosphoinositide 3-kinase (PI3K), and focal adhesion kinase (FAK), and on the survival of hepatocellular carcinoma (HCC) nude mice. METHODS: Forty male nude mice were randomly divided into 4 groups. Human HCC tissue was implanted in the livers of three groups. After 24 h, the three groups were treated respectively with JPJDF (37.5 g/kg), saline (20 mL/kg) and Tegafur (FT-207, 160 mg/kg) once a day for 10 weeks. The control group without implanting the tissue was concurrently treated with saline (20 mL/kg). The survival data and body weight of all mice were recorded, and expression levels of PTEN, PI3K and FAK in normal tissue and cancer tissue of the livers were eval-uated with immunohistochemical method. RESULTS: The cumulative survival rate of the mice in the JPJDF group was higher than those of the other groups. The rate of weight loss was the lowest in JPJDF group. The survivability and weight loss rate in FT-207 group were the poorest in all groups. The expression intensity of PTEN was higher in normal tissues than in cancer tissues, and lower in the normal tissues of HCC models than in that of mice without HCC. The PTEN expression intensity in normal tissue and cancer tissue from mice treated with FT-207 were lower than that from the mice treated with JPJDF or saline.The expression intensity of PI3K was higher in cancer tissue than in normal tissue. The PI3K expression intensity was the lowest in normal tissue and cancer tissue from mice treated with JPJDF, and the intensity from mice treated with FT-207 was the highest. In mice treated with JPJDF, the expression intensity of FAK was higher in the normal tissue and lower in the cancer tissue than those of the other treatment groups. CONCLUSION: The mechanism accounting for the prolonged survival of HCC-bearing mice treated with JPJDF might be related to the reduction in weight loss and the benign regulation of PTEN, PI3K, and FAK. | Baoguo Sun Jun Meng Ting Xiang Zexiong Chen Yulong Li Lisha Lu Shijun Zhang Xiaolin Chen | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 12 |
| 2 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 3 | Structure of the receptor-activated human TRPC6 and TRPC3 ion channels显示文摘TRPC6 和 TRPC3 是属于正规短暂受体潜力(TRPC ) 的家庭的激活受体的 nonselective 阳离子隧道隧道。他们被 diacylglycerol 激活,一个类脂化合物秒送信人。TRPC6 和 TRPC3 涉及许多生理的过程并且在人的基因疾病含有。这里我们在场在有最新识别的高亲密关系的禁止者 BTDM 的建筑群的人的 TRPC6 homotetramer 的结构由单个粒子的 cryo 电子显微镜学解决了到 3.8?分辨率。我们也在 4.4 点介绍人的 TRPC3 的结构吗?分辨率。这些结构显示出塑造钟的 cytosolic 层在保持 transmembrane 层的二层的体系结构。包括 N 终端 ankyrin 重复和 C 终端卷卷, cytosolic 领域的广泛的内部子单元的相互作用贡献 tetramer 集会。高亲密关系的禁止者 BTDM 在 S5-S6 毛孔领域和电压之间挤像传感器的领域禁止隧道开。我们的结构揭开 TRPC 隧道的分子的建筑学并且为理解这些隧道的机制提供一个结构的基础。 | Qinglin Tang Wenjun Guo Li Zheng Jing-Xiang Wu Meng Liu Xindi Zhou Xiaolin Zhang Lei Chen | 2018 | Cell Research2018，28，7： | 10 |
| 4 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 5 | Glycerol aerobic oxidation to glyceric acid over Pt/hydrotalcite catalysts at room temperature显示文摘Glycerol(GLY) aerobic oxidation in an aqueous solution is one of the most prospective pathways in biomass transformation, where the supported catalysts based on noble metals(mainly Au, Pd, Pt) are most commonly employed. Herein, Pt nanoparticles supported on rehydrated MgxAl1-hydrotalcite(denoted as re-MgxAl1-LDH-Pt) were prepared via impregnation-reduction method followed by an in situ rehydration process, which showed high activity and selectivity towards GLY oxidation to produce glyceric acid(GLYA) at room temperature. The metal-support interfacial structure and catalyst basicity were modulated by changing the Mg/Al molar ratio of the hydrotalcite precursor, and the optimal performance was achieved on re-Mg6Al1-LDH-Pt with a GLY conversion of 87.6% and a GLYA yield of 58.6%, which exceeded the traditional activated carbon and oxide supports. A combinative study on structural characterizations(XANES, CO-FTIR spectra, and benzoic acid titration) proves that a higher Mg/Al molar ratio promotes the formation of positively charged Ptd+species at metal-support interface, which accelerates bond cleavage of a-C–H and improves catalytic activity. Moreover, a higher Mg/Al molar ratio provides a stronger basicity of support that contributes to the oxidation of terminal-hydroxyl and thus enhances the selectivity of GLYA. This catalyst with tunable metal-support interaction shows prospective applications toward transformation of biomass-based polyols. | Junbo Zhang Xiaolin Li Ming Xu Yusen Yang Yinwen Li Ning Liu Xiaoyu Meng Lifang Chen Shuxian Shi Min Wei | 2019 | Science Bulletin2019，64，23： | 8 |
| 6 | Three-dimensional interconnected Ni(Fe)OxHy nanosheets on stainless steel mesh as a robust integrated oxygen evolution electrode显示文摘 | Qi Zhang Haixia Zhong Fanlu Meng Di Bao Xinbo Zhang Xiaolin wei | 2018 | Nano Research2018，11，3： | 8 |
| 7 | The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis显示文摘MSH5,傻瓜相当或相同的事物脱氧核糖核酸失配修理蛋白质家庭的一个成员,被显示了在象老鼠,开始发育的酵母和 Caenorhabditis elegans 那样的多样的有机体为合适的同源染色体再结合被要求。在这篇论文,我们证明带通常认为的破坏 AtMSH5 基因的变异的 Arabidopsis 植物在 meiotic 期间展出缺点,生产不能生存的花粉粒和反常胚囊的一个比例,并且从而导致在富饶的减少。AtMSH5 表示被限制到 meiotic 花发芽,它在成熟分裂期间与一个可能的角色一致。男成熟分裂的 Cytological 分析从 diplotene 揭示了众多的 univalents 的存在到中期我,它在交叉频率与大减小被联系。在异种的剩余 chiasmata 的平均数字每性母细胞被归结为 2.54,它在野生型占约 25% 数量。这里,量的细胞遗传学的分析表明在 Atmsh5 异种的剩余 chiasmata 在 meiocytes 之中是随机分布式的,建议 AtMSH5 有在干扰敏感的交叉形成期间的一个必要角色。总起来说,证据显示 AtMSH5 通过在前期期间便于交叉形成支持相应再结合我在 Arabidopsis。 | Xiaoduo Lu Xiaolin Liu Lizhe An Wei Zhang Jian Sun Huijuan Pei Hongyan Meng Yunliu Fan Chunyi Zhang | 2008 | Cell Research2008，18，5： | 6 |
| 8 | Multi-constellation GNSS precise point positioning with multi-frequency raw observations and dual-frequency observations of ionospheric-free linear combination显示文摘Precise point positioning(PPP)is famous for its capability of high-precision positioning with just one station as long as the receiver can receive global navigation satellite system(GNSS)signals.With the rapid development of BDS and Galileo,the number of available satellites for positioning has increased significantly.In addition,GPS III,GLONASS-K,BDS,and Galileo satellites can transmit triple-frequency signals.The potentials of multi-constellation GNSS PPP requires further analysis on a global scale.Therefore,we selected 96 multi-GNSS experiment(MGEX)stations with a global distribution and used 1 week’s data to assess the PPP performance.The results show that the PPP based on multi-frequency raw observations with spatial and temporal constraints has better performance than PPP using dual-frequency ionospheric-free observations.The main contribution of multi-constellation GNSS PPP is to shorten the convergence time.The convergence time for GPS PPP is approximately 40 min,which can be shortened to less than 20 min in multi-GNSS PPP.After convergence,the positioning accuracy of multi-GNSS PPP is improved by 0.5 to 1.0 cm compared with GPS or GLONASS PPP.The positioning accuracy of multi-GNSS could be further improved in the future with the BDS and Galileo precise products of orbits,clock and phase center offset/variation. | Xiangdong An Xiaolin Meng Weiping Jiang | 2020 | Satellite Navigation2020，1，1： | 3 |
| 9 | IGFBP7 regulates sepsis-induced epithelial-mesenchymal transition through ERK1/2 signaling显示文摘The epithelial-mesenchymal transition(EMT)process results in fibrosis of renal tubular epithelial cells and is of great importance in the development of acute kidney injury(AKI).Urinary IGF-binding protein-7(IGFBP7)was obviously increased in AKI and is considered to be a biomarker for AKI.However,whether it has an effect on the inhibition of lipopolysaccharide(LPS)-induced EMT in human HK2 cells and on that of cecal ligation and puncture(CLP)-induced EMT in human HK2 cells and in mice remains to be elucidated.Western blot analysis was performed to examine the phosphorylation of ERK1/2 level and expressions of IGFBP7,ERK1/2,EMT markers,such as E-cadherin,α-SMA,and vimentin,and EMT regulatory factors,such as Snail,transforming growth factor-β1(TGF-β1),and connective tissue growth factor(CTGF).The levels of IGFBP7,TGF-β1,and CTGF were detected by enzyme linked immunosorbent assay(ELISA).Concentrations of creatinine(Cr),blood urea nitrogen(BUN),and albumin(ALB)were measured by biochemical analysis.Here,we found that LPS promoted EMT and ERK1/2 activation in HK2 cells,which were inhibited by silencing of IGFBP7.Furthermore,IGFBP7 overexpression significantly increased EMT and ERK1/2 activation in HK2 cells,which were inhibited by ERK1/2 signaling inhibitor PD98059.IGFBP7 knockdown effectively attenuated renal fibrosis,concentrations of Cr,BUN and ALB,and activation of ERK1/2 signaling in CLP-induced mice.These results suggest that inhibiting IGFBP7 can effectively protect the renal tubular epithelial cells from EMT induced by LPS or CLP both in vitro and in vivo,which may be associated with inactivation of ERK1/2 signaling. | Xiaolin Wang Yan Li Zhenzhen Zhao Yan Meng Jinjun Bian Rui Bao Kaimin Zhu Tao Yang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，8： | 3 |
| 10 | Space qualification mechanical tests of HTS filters for satellite application显示文摘High performance high-temperature superconducting (HTS) filters have been designed and constructed for satellite application. The filters are actually a superconducting integration of an 8-pole band-pass filter with an adjustable band-stop filter onto a single piece of LaAlO3 substrate (with dimension of 0.5×45×20 mm3). Typical results of the filters, i.e., Filters A (made by YBCO) & B (made by TBCCO) will be reported. The measured responses of Filter A showed excellent specifications, e.g., an insertion loss less than 0.1 dB, a return loss better than -22.5 dB in pass-band, band-edge steepness greater than 12 dB/MHz and out-of-band rejection at a certain band deeper than -110 dB. To satisfy the requirement of rocket launch and space operation, three filters of the above design have undergone mechanical environmental simulation tests for space qualification. Detailed analysis of the response curves of Filter B measured before and after the tests showed that no noticeable change in the per-formance can be found. All the filters passed the rigorous ground simulation tests, which is the first time in China for HTS devices and provided a solid foundation for satellite applications of high-temperature superconductors in the near future. | HUANG JianDong SUN Liang LI ShunZhou MENG QingDuan ZHANG Qiang LI Fei ZHANG XueQiang LI ChunGuang HE AiSheng LI Hong GU ChangZhi LUO Qiang SUN QinFen WANG XiaoLin SUN YiFan WANG ZhiBing WANG YunFei LUO Sheng HE YuSheng | 2007 | Chinese Science Bulletin2007，52，13： | 3 |
| 11 | Integer ambiguity resolution in precise point positioning: method comparison显示文摘 | Jianghui Geng Xiaolin Meng Alan H. Dodson Felix N. Teferle | 2010 | Journal of Geodesy2010，，9： | 2 |
| 12 | Preparation of La0.67Ca0.23Sr0.1MnO3 thin films with interesting electrical and magnetic properties via pulsed-laser deposition显示文摘Manganese oxides with a perovskite-type Re_(1-x)D_xMnO_3(Re:heavy rare-earth elements,D:divalent alkali metal)structure have attracted interest because of the complex interaction between their electrons,lattices,and spins[1-5].Generally,manganese oxides with the structure Re_(1-x)D_xMnO_3 have special properties.For example,the half-metallic manganites,such as La_(2/3)Sr_(1/3)MnO_3 and La_(2/3)Ca_(1/3)MnO_3,wherein the conduction electrons are completely spin polarized。 | Shuai Xue XiaoLin Zhao JianLu Wang BoBo Tian Hai Huang CaiMin Meng Lan Liu Lei Ye JingLan Sun XiangJian Meng XiaoDong Zhang JunHao Chu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 2 |
| 13 | Development and evaluation of the refined zenith tropospheric delay(ZTD)models显示文摘The tropospheric delay is a significant error source in Global Navigation Satellite System(GNSS)positioning and navigation.It is usually projected into zenith direction by using a mapping function.It is particularly important to establish a model that can provide stable and accurate Zenith Tropospheric Delay(ZTD).Because of the regional accuracy difference and poor stability of the traditional ZTD models,this paper proposed two methods to refine the Hopfield and Saastamoinen ZTD models.One is by adding annual and semi-annual periodic terms and the other is based on Back-Propagation Artificial Neutral Network(BP-ANN).Using 5-year data from 2011 to 2015 collected at 67 GNSS reference stations in China and its surrounding regions,the four refined models were constructed.The tropospheric products at these GNSS stations were derived from the site-wise Vienna Mapping Function 1(VMP1).The spatial analysis,temporal analysis,and residual distribution analysis for all the six models were conducted using the data from 2016 to 2017.The results show that the refined models can effectively improve the accuracy compared with the traditional models.For the Hopfield model,the improvement for the Root Mean Square Error(RMSE)and bias reached 24.5/49.7 and 34.0/52.8 mm,respectively.These values became 8.8/26.7 and 14.7/28.8 mm when the Saastamoinen model was refined using the two methods.This exploration is conducive to GNSS navigation and positioning and GNSS meteorology by providing more accurate tropospheric prior information. | Fei Yang Xiaolin Meng Jiming Guo Debao Yuan Ming Chen | 2021 | Satellite Navigation2021，2，1： | 2 |
| 14 | Dry-regulated hydrogels with anisotropic mechanical performance and ionic conductivity显示文摘Nature consists of various soft tissues with well-ordered hierarchical anisotropic structures, which play essential roles in biological systems to exhibit particular functions. Mimicking bio-tissues, synthetic hydrogels with anisotropic structures have received considerable attention in recent years. However, existing approaches to fabricate anisotropic hydrogels often require complicated procedures, which are timeconsuming and labor-demanding. Inspired by the dry-induced crystallization phenomenon, we report a simple yet effective prestretching-drying-swelling method to afford anisotropic crystalline polyvinyl alcohol hydrogels. Owing to the distinct anisotropic microstructure, the hydrogels demonstrate excellent mechanical properties with noticeable directional distinction. It is revealed that both the enhancing of pre-orientation strain and the extending of heating time make the hydrogels with better mechanical properties and more remarkable anisotropicity. Owing to the anisotropically aligned structure, the hydrogels exhibit remarkably differential ionic conductivity: the difference between the parallel and vertical conductivity of the same sample can reach as high as 6.6 times, making the materials possible candidates as nano-conductive materials. We anticipate that this simple yet effective approach may become highly useful for fabricating oriented hydrogels and endow the materials with more promising application prospects in the future. | Ping Li Yi Liu Ziang Wang Xuemei Xiao Guozhe Meng Xiaolin Wang Hong-Lei Guo Hui Guo | 2022 | Chinese Chemical Letters2022，33，2： | 2 |
| 15 | Therapeutic effects of a novel tylophorine analog, NK‐007, on collagen‐induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation显示文摘 | Ti Wen Yangguang Li Meng Wu Xiaolin Sun Xiucong Bao Yuquan Lin Jianlei Hao Lin Han Guangchao Cao Ziwen Wang Yuxiu Liu Zhenzhou Wu Zhangyong Hong Puyue Wang Liqing Zhao Zhanguo Li Qingmin Wang Zhinan Yin | 2012 | Arthritis & Rheumatism2012，，9： | 2 |
| 16 | Engineering of Co_(3O)_(4)@Ni_(2)P heterostructure as trifunctional electrocatalysts for rechargeable zinc-air battery and self-powered overall water splitting显示文摘Rational design of highly efficient,robust and nonprecious electrocatalysts for the oxygen reduction reaction(ORR),oxygen evolution reaction(OER)and hydrogen evolution reaction(HER)is highly demanded and challenging.Here,heterostructural Co_(3O)_(4)@Ni_(2)P arrays with numerous reaction sites,unique interfacial electronic structure and fast charge transfer kinetics are developed as electrocatalysts for rechargeable Zn-air batteries and overall water splitting.Both density functional theory calculation and X-ray absorption fine structure analysis manifest that the synergistic structural and abundant electronic modulations interfaces are formed,thus simultaneously promoting the electrocatalytic kinetics,activities and stabilities.Specifically,it can achieve an ultralow overpotential of 270 m V and 28 m V at 10 m A cm^(-2) for OER and HER,respectively.The water electrolyzer delivers a current density of 10 m A cm^(-2) at 1.563 V;furthermore,rechargeable Zn-air batteries triggered by this heterostructure can achieve excellent cyclic stability of 177 h(2 h per cycle)at 10 m A cm^(-2);both devices are superior to the Pt/C+Ir/C.This work not only designs an efficient trifunctional electrocatalyst but also paves an avenue to understand the heterostructure engineering for catalysts development and disclose the underlying relationship of interfacial electronic structures and catalytic properties. | Xiaolin Hu Tongxin Yang Zuguang Yang Zongyang Li Ronghua Wang Meng Li Guangsheng Huang Bin Jiang Chaohe Xu Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，20： | 1 |
| 17 | Physiological and biochemical responses in peach fruit to BTH treatment during storage at room temperature显示文摘 | Xiaolin Zheng Shiping Tian Xianghong Meng | 2007 | Food Chemistry2007，104，： | 1 |
| 18 | Desulfurization of model gasoline on modified bentonite显示文摘 | Tang Xiaolin Meng Xuan Shi Li | 2011 | Industrial & Engineering Chemistry Research2011，50，12： | 1 |
| 19 | Heavy oil O/W emulsion properties under the test loop conditions显示文摘 | Meng Jiang Ren Liancheng Wei Xiaolin | 2012 | OGST2012，31，3： | 1 |
| 20 | Rapid re-convergences to ambiguity-fixed solutions in precise point positioning显示文摘 | Jianghui Geng Xiaolin Meng Alan H. Dodson Maorong Ge Felix N. Teferle | 2010 | Journal of Geodesy2010，，12： | 1 |
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