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| 1 | Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy显示文摘AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical practice.METHODS The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were analyzed.RESULTS The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms. | Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro Masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki Kondo Shiei Yoshida Tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi Takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi Azuma | 2017 | World Journal of Gastroenterology2017，23，11： | 5 |
| 2 | Overexpression of a 60-kDa heat shock protein enhances cytoprotective function of small intestinal epithelial cells显示文摘 | Makiko Takada Michiro Otaka Taiji Takahashi Yuko Izumi Kumiko Tamaki Tomoyoshi Shibuya Naoto Sakamoto Taro Osada Sou Yamamoto Ryuichi Ishida Masaru Odashima Hideaki Itoh Sumio Watanabe | 2010 | Life Sciences2010，，13： | 2 |
| 3 | A novel current-mode active-R biquad using differential-input differential-output operational amplifiers显示文摘 | TSUKUTANI Takao TSUIKI Sumio ISHIDA Masaru | 1995 | Int J Electronices1995，79，5： | 1 |
| 4 | Graphical exergy analysis of complex cycles显示文摘 | JIN H G MASARU ISHIDA | 1993 | Energy1993，18，： | 1 |
| 5 | Graphical exergy analysis of complex cycles显示文摘 | Masaru Ishida | 1993 | Energy1993，18，6： | 1 |
| 6 | Development of high-capacity nickel-metal hydride batteries using superlattice hydrogen-absorbing alloys 显示文摘 | Shigekazu Yasuoka Yoshifumi Magari Teesuyuki Murata Tadayoshi Tanaka Jun Ishida Hiroshi Nakamura Toshiyuki Nohma Masaru Kihara Yoshitaka Baba Hirohito Teraoka | 2006 | Journal of Power Sources2006，156，： | 1 |
| 7 | Development of a novel chemical-looping combustion:syn- thesis of a looping material with a double metal oxide of CoO-NiO显示文摘 | Hongguang Jin Toshihiro Okamoto Masaru Ishida | 1998 | Energy & Fuels1998，12，6： | 1 |
| 8 | Prescreening of a High-Risk Group for Gastric Cancer by Serologically Determined Helicobacter pylori Infection and Atrophic Gastritis显示文摘 | Shigeto Mizuno Ikuya Miki Tsukasa Ishida Masaru Yoshida Mitsuko Onoyama Takeshi Azuma Yasuki Habu Hideto Inokuchi Kotaro Ozasa Kazumasa Miki Yoshiyuki Watanabe | 2010 | Digestive Diseases and Sciences2010，，11： | 1 |
| 9 | A new type of coal gas fueled chemical: Looping combustion显示文摘 | Jin H Ishida Masaru | 2004 | Fuel2004，83，： | 1 |
| 10 | Plasma ghrelin isoforms and gastric ghrelin O -acyltransferase expression are influenced by Helicobacter pylori status显示文摘 | Takashi Ando Shigeto Mizuno Tsukasa Ishida Yasuyuki Kondo Ikuya Miki Masaru Yoshida Takeshi Azuma Takeshi Ishikawa Tomohisa Takagi Nobuaki Yagi Satoshi Kokura Yuji Naito Toshikazu Yoshikawa Akihiro Asakawa Akio Inui | 2012 | Nutrition2012，，10： | 1 |
| 11 | Simulation of power cycle with energy utilization diagram 显示文摘 | Thongchai Srinophakun Sangapong Laowithayangkul Masaru Ishida | 2001 | Energy Conversion & Management2001，42，： | 1 |
| 12 | Overview of the MITI Nankai Trough wells: A milestone in the evaluation of methane hydrate resources 显示文摘 | Yoshihiro Tsuji Hisashi Ishida Masaru Nakamizu | 2004 | Resource Geology2004，54，： | 1 |
| 13 | Prescreening of a High-Risk Group for Gastric Cancer by Serologically Determined Helicobacter pylori Infection and Atrophic Gastritis显示文摘 | Shigeto Mizuno Ikuya Miki Tsukasa Ishida Masaru Yoshida Mitsuko Onoyama Takeshi Azuma Yasuki Habu Hideto Inokuchi Kotaro Ozasa Kazumasa Miki Yoshiyuki Watanabe | 2010 | Digestive Diseases and Sciences2010，，11： | 1 |
| 14 | , Overview of the MITI Nankai Trough Wells: A Milestone in the Evaluation of Methane Hydrate Resources 显示文摘 | Yoshihiro Tsuji Hisashi Ishida Masaru Nakamizu etc | 2004 | Resource Geology2004，54，1： | 1 |
| 15 | Graphical exergy analysis of complex cycles 显示文摘 | Hongguang Jin Masaru Ishida | 1993 | Energy1993，18，6： | 1 |
| 16 | A new type of coal gas fueled chemical-looping combustion显示文摘 | Jin Hongguang Masaru Ishida | 2004 | Fuel2004，83，： | 1 |
| 17 | ,Overview of the MITI Nankai Trough Wells: A Milestone in the Evaluation of Methane Hydrate Resources显示文摘 | YoshihiroTsuji Hisashi Ishida Masaru Nakamizu etc | 2004 | Resource Geology2004，54，1： | 1 |
| 18 | A new type of coal gas fueled chemical-looping combustion显示文摘 | Jin H Ishida Masaru | 2004 | Fuel2004，83，1718： | 1 |
| 19 | A new type of coal gas fueled chemical-looping combustion显示文摘 | Hongguang Jin Masaru Ishida | 2004 | Fuel2004，83，4： | 1 |
| 20 | A novel gas turbine cycle with hydrogen-fueled chemical-looping combustion显示文摘 | Jin H Ishida Masaru | 2000 | Intemational Journal of Hydrogen Energy2000，25，12： | 1 |
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