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| 1 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 2 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 3 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 4 | ScaI polymorphism of the atrial natriuretic peptide gene and blood pressure in subjects without clinical manifestations of atherosclerotic disease显示文摘 | Jerzy B Marcin G Siebert J | 1999 | Arterial Hypertension1999，3，4： | 1 |
| 5 | Comparison of LaC13 : Ce and NaI (TI) Scintillators in -ray Spectrometry 显示文摘 | Marcin B Marek M Maciej K | 2005 | Nuclear Instruments and Methods in Physics Research2005，，： | 1 |
| 6 | Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice显示文摘 | Jolanta K Marcin B | 2007 | Eur J Pharmacol2007，558，： | 1 |
| 7 | Synthesis and spectral properties of colloidal Nd3 - doped NaYF4 nanocrystals 显示文摘 | Artur B Dominika W Marcin N Wieslaw S | 2011 | Optical Materials2011，33，： | 1 |
| 8 | Secure and task abortion aware GA-based hybridmetaheuristics for grid scheduling显示文摘 | JOANNA K FATOS X MARCIN B | 2010 | Computer Science2010，1，： | 1 |
| 9 | Comparison of LaCl3:Ce and NaI(TI)scintillators in γ-ray spectrometry显示文摘 | MARCIN B MAREK M MACIEJ K | 2005 | Nuclear Instruments and Methods in Physics Research A2005，537，： | 1 |
| 10 | The conceptual model of an eco-industrial park based upon ecological relationships 显示文摘 | Ewa L B Marcin B Marcinkowski A | 2009 | Journal of Cleaner Production2009，17，7： | 1 |
| 11 | Randomized clinical trialof posterior retroperitoneoscopic adrenalectomy versus lateraltransperitoneal laparoscopic adrenalectomy with a 5-year follow-up显示文摘 | Marcin B Aleksander K Wojciech N | 2014 | Ann Surg2014，260，： | 1 |
| 12 | Plasma adiponecin concentration and left ventricular hypertrophy in kidney transplant patients显示文摘 | Marcin A Anna B Aureliusa K | 2011 | Clinical Transplantation2011，，25： | 1 |
| 13 | The conceptual model of an eco-industrial park based upon ecological relationships 显示文摘 | EWA L B MARCIN B ANDRZEJ M | 2009 | Journal of Cleaner Production2009，17，： | 1 |
| 14 | TGF-β signaling in fi- brosis显示文摘 | Anna B Marcin D Nikolaos G | 2011 | Growth Factors2011，29，5： | 1 |
| 15 | Ammonolysis of(3-chloropropyl) trimethoxysilne显示文摘 | MARCIN B ROBERT P EUGENIUSZ M | 2006 | Journal of Hazardous Materials2006，136，3： | 1 |
| 16 | Plasma adiponectin concentration and left ventricular hypertrophy in kidney transplant patients 显示文摘 | Marcin A Anna B Aureliusz K | 2011 | Clinical Transplantation2011，25，： | 1 |
| 17 | Cryopreservation of embryogenic tissues of Picea omorika (Serbian spruce)显示文摘 | Teresa HP Pawe? C Marcin M Krystyna B | 2010 | Plant Cell Tissue Organ Cult2010，102，1： | 1 |
| 18 | Smad3 signaling critically regu- lates fibroblast phenotype and function in healing myocardial infarc- tion显示文摘 | Martin D Marcin B Na Li | 2010 | Circ Res2010，107，3： | 1 |
| 19 | Analysing the development of cooperation in MANETs using evolutionary game theory显示文摘 | MARCIN S PASCAL B | 2013 | Journal of Supercomputing2013，63，3： | 1 |
| 20 | Combined distiller waste utilisation and combustion gases desulphurisation method:The case study of soda-ash industry显示文摘 | Tomasz K Roman B Marcin C | 2007 | Conservation and Recycling2007，51，： | 1 |
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