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| 1 | Immune cells in term and preterm labor显示文摘 | Nardhy Gomez-Lopez Derek StLouis Marcus A Lehr Elly N Sanchez-Rodriguez Marcia Arenas-Hernandez | 2014 | Cellular & Molecular Immunology2014，11，6： | 17 |
| 2 | Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability显示文摘AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric adenocarcinomas.METHODS: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). Detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact test.RESULTS: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and MSI.CONCLUSION: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression. | Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan Rodrigues Fabrício de Carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini | 2010 | World Journal of Gastroenterology2010，16，3： | 6 |
| 3 | Impact of chronic disease self-management programs on type 2 diabetes management in primary care显示文摘AIM: To assess the effectiveness of the Chronic Disease Self-Management Program(CDSMP) on glycated hemoglobin A1c(HbA1c) and selected self-reported measures.METHODS: We compared patients who received a diabetes self-care behavioral intervention, the CDSMP developed at the Stanford University, with controls whoreceived usual care on their HbA1c and selected self-reported measures, including diabetes self-care activities, health-related quality of life(HRQOL), pain and fatigue. The subjects were a subset of participants enrolled in a randomized controlled trial that took place at seven regional clinics of a university-affiliated integrated healthcare system of a multi-specialty group practice between January 2009 and June 2011. The primary outcome was change in HbA1c from randomization to 12 mo. Data were analyzed using multilevel statistical models and linear mixed models to provide unbiased estimates of intervention effects.RESULTS: Demographic and baseline clinical characteristics were generally comparable between the two groups. The average baseline HbA1c values in the CDSMP and control groups were 9.4% and 9.2%, respectively. Significant reductions in HbA1c were seen at 12 mo for the two groups, with adjusted changes around 0.6%(P < 0.0001), but the reductions did not differ significantly between the two groups(P = 0.885). Few significant differences were observed in participants' diabetes self-care activities. No significant differences were observed in the participants' HRQOL, pain, or fatigue measures.CONCLUSION: The CDSMP intervention may not lower HbA1c any better than good routine care in an integrated healthcare system. More research is needed to understand the benefits of self-management programs in primary care in different settings and populations. | Samuel N Forjuoh Marcia G Ory Luohua Jiang Ann M Vuong Jane N Bolin | 2014 | World Journal of Diabetes2014，5，3： | 6 |
| 4 | Time course of detection of viral and serologic markers preceding human immunodeficiency virus type 1 seroconversion显示文摘 | Steven N Francis Lee Marcia L | 2000 | J Infect Dis2000，175，： | 1 |
| 5 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial显示文摘 | Marcia S Brose Christopher M Nutting Barbara Jarzab Rossella Elisei Salvatore Siena Lars Bastholt Christelle de la Fouchardiere Furio Pacini Ralf Paschke Young Kee Shong Steven I Sherman Johannes W A Smit John Chung Christian Kappeler Carol Pe?a István Mo | 2014 | The Lancet2014，，： | 1 |
| 6 | Exposure to Phthalates and Breast Cancer Risk in Northern Mexico显示文摘 | López-Carrillo Lizbeth Hernández-Ramírez Raúl U Calafat Antonia M Torres-Sánchez Luisa Galván-Portillo Marcia Needham Larry L Ruiz-Ramos Rubén Cebrián Mariano E | 2010 | Environmental Health Perspectives2010，，4： | 1 |
| 7 | Time course of detection of viral and serologic markers preceding human immunodeficiency virus type 1 seroconversion显示文摘 | Teven N Francis Lee Marcia L | 2000 | J InfectDis2000，175，： | 1 |
| 8 | ?Emergent anxiety after antidepressant initiation:a retrospective cohort study of Veterans Affairs Health System patients with depression显示文摘 | Zhiguo Li Paul N Pfeiffer Katherine J Hoggatt Kara Zivin Karen Downing Dara Ganoczy Marcia Valenstein | 2011 | Clinical therapeutics2011，33，12： | 1 |
| 9 | Time course of detection of viral and aerologic markers preceding human immunodeficiency virus type 1 seroconversion显示文摘 | Strvrn N Francis Lee Marcia L | 2000 | J Infect Dis2000，175，： | 1 |
| 10 | Regulation of Telomerase and Telomeres: Human Tumor Viruses Take Control 显示文摘 | Marcia B Christophe N | 2008 | J Natl Cancer Inst2008，100，2： | 1 |
| 11 | Antimicrobial activity ofrhamnolipids against Listeria monocytogenes andtheir synergistic interaction with nisin显示文摘 | LUANA M MARCIA N | 2013 | FoodControl2013，29，： | 1 |
| 12 | Methyl tert-butyl ether and tert-butyl alcohol degradation by fusarium solani显示文摘 | Miguel Maga(n)a-Reyes Marcia Morales Sergio Revah | 2005 | Biotechnology Letters2005，27，22： | 1 |
| 13 | Role of the extensin superfamily in primary cell wall architecture显示文摘 | Lamport Derek T A Kieliszewski Marcia J Chen Y N | 2011 | Plant physiology2011，156，1： | 1 |
| 14 | Mo- lecular detection and quantification of nifH gene sequences in the rhi- zosphere of sorghum ( Sorghum bicolor) sown with two levels of nitro- gen fertilizer显示文摘 | Coelho Marcia R R Marriel Ivanildo E Jenkins Sasha N | 2009 | Applied Soil Ecology2009，42，1： | 1 |
| 15 | Regulation of Telomerase and Telomeres:Human Tumor Viruses Take Control 显示文摘 | Marcia B Christophe N | 2008 | J Natl Cancer Inst2008，100，2： | 1 |
| 16 | Determination of chlorine, bromine and iodine in milksamples by ICP-OES 显示文摘 | Juliana N Marcia A Mesquita S Pedro V Elisabeth 0 | 2003 | Journal of Analytical AtomicSpectrometry2003，18，： | 1 |
| 17 | Effective oral administration of 17-β-estradiol to female C57BL/6J mice through the drinking water 显示文摘 | Marcia N Gordon Heinz HO | 1986 | Biol of reprod1986，35，： | 1 |
| 18 | One-step enrichment of nucleated red blood cells显示文摘 | Neelima M Bhat Marcia M Bieber and Nelson N H Teng | 1993 | Journal of Immunological Methods1993，158，： | 1 |
| 19 | Producton and properties of a surfactant obtained from Bacillus subtilis grown on cassava wastewater显示文摘 | MARCIA N GLAUCIA M P | 2006 | Bioresource Technology2006，97，2： | 1 |
| 20 | Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin transgenes 显示文摘 | Leigh H Marcia N Gordon | 1998 | Nature Medicine1998，4，： | 1 |
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