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47篇 您的检索式:作者名="MAIELLO M"
    题名 作者 年代 出处 被引量
1一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P 2014中华神经外科疾病研究杂志2014,13,5:6
2EGFR and MEK blockade in tri- ple negative breast cancer ceils 显示文摘MAIELLO M R D'ALESSIO A 2015J Cell Biochem2015,116,12:1
3Defense mechanisms as outcome measure in short-term psychotherapy related to symptoms, severity and overall functioning: a preliminary study显示文摘Coccanari de' Fornari MA Piccione M Maiello L 2011Res Psychiatry2011,46,1:1
4Evaluation of cytotoxic concentration-time response in A549 cells exposed to respirable α-quartz显示文摘FANIZZA C FRESEGNA A M MAIELLO R 2009J Appl Toxicol2009,29,:1
5Percutaneous translumi- nal coronary revascularization in women: Higher risk of dissection and need for stenting显示文摘Carcagni A Carnellini M Maiello L 2000ItaI Heart J2000,1,:1
6Fetal lung lesions diagnosis:the crucial role of ultrasonography显示文摘Pedata R Palermo M Maiello M 2009J Prenat Med2009,3,4:1
7Fate of octamethylcyclotetrasiloxane (OMCTS) in the atmosphere and in sewage treatment plants as an estimation of aquatic exposure显示文摘Mueller J A Di Tom D M Maiello J A 1995Environmental Toxicology and Chemistry1995,14,10:1
8Epidermal growth factor receptor tyrosine kinase inhibitors (EG- FR-TKIs) : simple drugs with a complex mechanism of action显示文摘Normanno N Maiello M R De Luca A 2003J''Cell Physiol2003,194,:1
9Increased expression of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevated glucose显示文摘Maiello M Boeri D Podesta F 0,,:1
10The RAS/RAF/MEK/ ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches 显示文摘De Luca A Maiello M R D'Alessio A 2012Expert Opin Ther Targets2012,16,:1
11Hypercoagulability during pregnancy: evidences for a thrombopllilic state显示文摘Maiello M Torella M Caserta L 2006Minerva Gineeol2006,58,41:1
12Resveratrol plus carbossimetyl-β-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis显示文摘Del Giudice M M Maiello N Capristo C 2014Curr Med Res Opin2014,30,10:1
13Arrhythmie risk in essential hypertension: late potentials 显示文摘PALMIERO P MAIELLO M 2004Minerva Cardioangiol2004,52,1:1
14Differential left atrial remodeling in LV diastolic dysfunction and mitral regurgitation显示文摘Maiello M Sharma RK Matteo CM 2009Echocardiography2009,26,:1
15Increased expressin of tissue plasminogen activator and its inhibitor and reduced fibrinolytic potential of human endothelial cells cultured in elevatedglucose显示文摘Maiello M Boeri D Podesta F 1992Diabetes1992,41,8:1
16Hypercoagulability during pregnancy: evidences for a thrombopllilic state显示文摘MAIELLO M TORELLA M CASERTA L 2006Minerva Ginecol2006,58,:1
17Fetal lung lesions diagnosis:the crucial role of ultrasonography显示文摘Pedata R Palermo M Maiello M 0,,4:1
18Spinal cord stimulation for the treatment of progressive systemic sclerosis and Raynaud's syndrome显示文摘FraneavigIia N Silvestro C Maiello M 1994Br J Neurosurg1994,8,5:1
19Arrhythmic risk in essential hypertension:late potentials显示文摘 Maiello M 2004Minerva Cardioangiol2004,52,:1
20Hypercoagulability during pregn-ancy; evidences for a thrombophilic state 显示文摘Maiello M Torella M Caserta L 2006Minerva Ginecol2006,58,5:1
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