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| 1 | Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas显示文摘Invasive nonfunctional pituitary adenomas(NFPAs) are difficult to completely resect and often develop tumor recurrence after initial surgery.Currently,no medications are clinically effective in the control of NFPA.Although radiation therapy and radiosurgery are useful to prevent tumor regrowth,they are frequently withheld because of severe complications.Boron neutron capture therapy(BNCT) is a binary radiotherapy that selectively and maximally damages tumor cells without harming the surrounding normal tissue.Folate receptor(FR)-targeted boron-10 containing carbon nanoparticles is a novel boron delivery agent that can be selectively taken up by FR-expressing cells via FR-mediated endocytosis.In this study,FR-targeted boron-10 containing carbon nanoparticles were selectively taken up by NFPAs cells expressing FR but not other types of non-FR expressing pituitary adenomas.After incubation with boron-10 containing carbon nanoparticles and following irradiation with thermal neutrons,the cell viability of NFPAs was significantly decreased,while apoptotic cells were simultaneously increased.However,cells administered the same dose of FR-targeted boron-10 containing carbon nanoparticles without neutron irradiation or received the same neutron irradiation alone did not show significant decrease in cell viability or increase in apoptotic cells.The expression of Bcl-2 was down-regulated and the expression of Bax was up-regulated in NFPAs after treatment with FR-mediated BNCT.In conclusion,FR-targeted boron-10 containing carbon nanoparticles may be an ideal delivery system of boron to NFPAs cells for BNCT.Furthermore,our study also provides a novel insight into therapeutic strategies for invasive NFPA refractory to conventional therapy,while exploring these new applications of BNCT for tumors,especially benign tumors. | DAI CongXin CAI Feng HWANG Kuo Chu ZHOU YongMao ZHANG ZiZhu LIU XiaoHai MA SiHai YANG YaKun YAO Yong FENG Ming BAO XinJie LI GuiLin WEI JunJi JIAO YongHui WEI ZhenQing MA WenBin WANG RenZhi | 2013 | Science China(Life Sciences)2013，56，2： | 8 |
| 2 | Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats显示文摘Dihydromyricetin(DHM),as a bioactive flavanonol compound,is mainly found in“Tengcha”(Ampelopsis grossedentata)cultivated in south of China.This study aimed to investigate the anti-hyperglycemic and antidyslipidemic activities of DHM using type 2 diabetes mellitus(T2D)rats,which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin.Forty-eight freshlyweaned rats were randomly assigned into the negative control(Blank),low dose(100 mg/kg),medium dose(200 mg/kg),high dose(400 mg/kg),and positive(40 mg/kg,met)groups.Fasting blood glucose and body weight were measured at weekly interval.Oral glucose tolerance tests were performed on days 42.The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects.Moreover,after the DHM treatment,p-Akt and p-AMPK expression was upregulated,and glycogen synthase kinase-3β(GSK-3β)expression was downregulated,indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3βsignaling pathway. | Maojun Yao Hui Teng Qiyan Lv Huifang Gao Tengming Guo Yiwen Lin Sihai Gao Meihu Ma Lei Chen | 2021 | Food Science and Human Wellness2021，10，2： | 6 |
| 3 | Dynamic Recrystallization Behaviour of Nb-Ti Microalloyed Steels显示文摘The dynamic recrystallization(DRX)behavior of Nb-Ti microalloyed steels was investigated by isothermal single compression tests in the temperature range of 900-1 150℃ at constant strain rates of 0.1-5 s-1.DRX was retarded effectively at low temperature due to the onset of dynamic precipitation of Nb and Ti carbonitrides,resulting in higher values of the peak strain.An expression was developed for the activation energy of deformation as a function of the contents of Nb and Ti in solution as well as other alloying elements.A new value of corrective factor was determined and applied to quantify the retardation produced by increase in the amount of Nb and Ti dissolved at the reheating temperature.The ratio of critical strain to peak strain decreases with increasing equivalent Nb content.In addition,the effects of Ti content and deformation conditions on DRX kinetics and steady state grain size were determined.Finally,the kinetics of dynamic precipitation was determined and effect of dynamic precipitation on the onset of DRX was clarified based on the comparison between precipitate pinning force and recrystallization driving force. | MA Liqiang LIU Zhenyu JIAO Sihai YUAN Xiangqian WU Di | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 3 |
| 4 | Optical switch basvd on vanadium dioxide thin films 显示文摘 | CHEN sihai MA Hong YI Xirrjian | 2004 | Infrared Physics Technology2004，45，4： | 1 |
| 5 | Vanadium oxide thin films deposited on silicon dioxide buffer layers by magnetron sputtering显示文摘 | CI-IEN Sihai MA Hong WANG Shuangbao | 2006 | Thin Solid Films2006，497，： | 1 |
| 6 | MOVPE Growth and Fabrication of 1.3μm High Power InGaAsP-InP Polarization-Insensitive Superluminescent Diodes with Complex Strained Quantum Wells显示文摘 | Hong Ma Sihai Chen Xinjian Yi Guangxi Zhu Jinyan Jin | 2004 | Optical and Quantum Electronics2004，，6： | 1 |
| 7 | Optical switchbased on vanadium dioxide thin films 显示文摘 | Chen Sihai Ma Hong Yi Xinjian | 2004 | Infrared Physics &Technology2004，45，4： | 1 |
| 8 | Vanadium oxide thin films deposited on silicon dioxide buffer layers by magnetron sputtering 显示文摘 | Chen Sihai Ma Hong Wang Shuangbao | 2006 | Thin Solid Films2006，497，12： | 1 |
| 9 | Vanadium oxide thin films deposited on silicon dioxide buffer layers by magnetron sputtering显示文摘 | CHEN Sihai MA Hong WANG Shuangbao | 2006 | Thin Solid Films2006，497，： | 1 |
| 10 | Smart VO 2 thin film for protection of sensitive infrared detectors from strong laser radiation显示文摘 | Sihai Chen Hong Ma Xinjian Yi Tao Xiong Hongcheng Wang Caijun Ke | 2004 | Sensors & Actuators: A Physical2004，，1： | 1 |
| 11 | 显示文摘 | Sihai Chen Hong Ma Xinjian Yi | 2004 | Sensors and Actuators A2004，115，： | 1 |
| 12 | Development of a roll-bonded UNS N08825 alloy clad pipeline steel in Baosteel显示文摘In this study,a roll-bonded UNS N088225 alloy clad pipeline steel was investigated and developed in Baosteel. Based on the requirements of a number of potential projects,we performed a series of strict evaluations including mechanical and corrosion tests. The results show the mechanical properties and corrosion resistance of this clad steel to be excellent and to meet the requirements of all the design parameters. | LIANG Xiaojun MA Tianjun FU Yanhong JIAO Sihai DING Jianhua YUAN Xiangqian WANG Baosen ZHANG Qingfeng | 2017 | Baosteel Technical Research2017，11，1： | 1 |
| 13 | Vanadium oxide thin films deposited on silicon dioxide buffer layers by magnetron sputtering显示文摘 | i Chen Sihai Ma Hong Wang Shuangbao | 2006 | Thin Solid Films2006，497，12： | 1 |
| 14 | Smart VO2 thin film for protection of sensitive infrared detectors from strong laser radiation显示文摘 | Chen Sihai Ma Hong Yi Xinjian | 2004 | Sensors and Actuators A2004，115，1： | 1 |
| 15 | Vanadium Oxide Thin Films Deposited on Silicon Dioxide Buffer Layers by Magnetron Sputtering 显示文摘 | Chen Sihai Ma Hong Wang Shuangbao | 2006 | Thin Solid Films2006，497，： | 1 |
| 16 | Vanadium Oxide Thin Films Deposited on Silicon Dioxide Buffer Layers by Magnetron Sputtering显示文摘 | Chen Sihai Ma Hong Wang Shuangbao | 2006 | Hin Solid Films2006，497，： | 1 |
| 17 | Optical switch based on vanadium dioxide thin films显示文摘 | CHEN Sihai MA Hong YI Xinjian | 2004 | Infrared Physics & Technology2004，45，4： | 1 |
| 18 | Dynamic recrystallization behaviour of Nb-Ti microalloyed steels显示文摘 | Liqiang Ma Zhenyu Liu Sihai Jiao Xiangqian Yuan Di Wu | 2008 | Journal of Wuhan University of Technology - Mater Sci Ed2008，，4： | 1 |
| 19 | 显示文摘 | Chen Sihai Ma Hong Yi Xinjian | 2004 | Infrared Physics & Technology2004，45，44： | 1 |
| 20 | Nanostructured vanadium dioxide thin films with low phase transition temperature显示文摘 | Chen Sihai Ma Hong Dai Jun | 2007 | Applied Physics Letters2007，90，10： | 1 |
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