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| 1 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 2 | Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro显示文摘 | Han SY Li HX Ma Xu | 2009 | Phytomedicine2009，16，2： | 1 |
| 3 | ImmunoCyt and cytokeratin,20 immunocytochemistry as adjunct markers for urine cytologic detection of bladder cancer:a prospective study显示文摘 | Li HX Li M Li CL Ma JH Wang MR Rao J | | 0，，： | 1 |
| 4 | Depressive symptoms,social isolation,and progression of coronary artery atherosclerosis:the Stockholm Female Coronary Angiography Study显示文摘 | Wang HX Mittleman MA Leineweber C | | 0，，： | 1 |
| 5 | Construction of 4'-isovalerylspiramycin-I-producing strain by in-frame partial deletion of 3-O-acyltransferase gene in Streptomyces spiramyceticus WSJ-1,the bitespiramycin producer显示文摘 | Ma CY Zhou HX Li JY | | 0，，01： | 1 |
| 6 | Radar echo and lightning characteris-tics analysis on a strong thunderstorm weather in Fuxin显示文摘 | MA HX YANG ZJ WANG W | 2010 | Meteorological and Environmental Research2010，1，50： | 1 |
| 7 | The nonosonic allogeneic cell phagocytosis of macrophages detected by flow cytometry and two photon fluorescence microscope 显示文摘 | Liu GW Ma HX Wu Y | 2006 | Transphant Immunology2006，16，： | 1 |
| 8 | Tribological properties of bismaleimide composites with surface-modified SiO2 nanopartieles显示文摘 | Yan HX Li PB Ning RC Ma X Y Zhang Z P | 2008 | Journal of Applied Polymer Science2008，110，3： | 1 |
| 9 | Aluminum-induced oxidative stress and changes in antioxidant defenses in the roots of rice varieties differing in Al tolerance 显示文摘 | Ma BH Gao L Zhang HX Cui J Shen ZG | 2012 | Plant Cell Rep2012，31，： | 1 |
| 10 | Polyphyllin D exerts potent anti-tumoureffects on lewis cancer cells under hypoxic conditions显示文摘 | Ma DD Lu HX Xu IS | 2009 | J Int Med Res2009，37，3： | 1 |
| 11 | Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats 显示文摘 | Han SY Li HX Ma X | 2013 | Journal of Ethnopharmacology2013，145，3： | 1 |
| 12 | Capecitabine for the treatment for ad- vanced gastric cancer:efficacy, safety and ethnicity 显示文摘 | Ma Y Tang L Wang HX | 2012 | J Clin Pharm Ther2012，37，3： | 1 |
| 13 | Risk factors associated with biliary pancreatitis in children 显示文摘 | Ma MH Bai HX Park AJ | 2012 | J Pediatr Gastroenterol Nutr2012，54，5： | 1 |
| 14 | Study on the factors affecting smoking a- mong high schools in China 显示文摘 | Ma JM Tao Q Song HX | 2002 | Dis Surv2002，17，2： | 1 |
| 15 | Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro 显示文摘 | Han SY Li HX Ma X | 2009 | Phytomedicine2009，16，8： | 1 |
| 16 | Comparison of minimum alveolar Concentration between intravenous isoflurane lipidemulsion and inhaled isoflurane in dogs 显示文摘 | Yang XL Ma HX Yang ZB | 2006 | Anesthesiology2006，104，3： | 1 |
| 17 | Application of bench mark dose approach in risk assessment 显示文摘 | Song XY Zhang L Sui HX Li JW Ma J Liu N | 2011 | 卫生研究2011，40，1： | 1 |
| 18 | Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression 显示文摘 | Zu XY Ma J Liu HX | 2011 | Breast Cancer Res2011，13，2： | 1 |
| 19 | Depression symptoms, social isolation, and progression of coronary artery atherosclerosis: the Stockholm Female Coronary Angiography Study 显示文摘 | Wang HX Mitteleman MA Leineweber C | 2006 | Psychother Psychother Psychosom2006，75，2： | 1 |
| 20 | Recombination in human coxsac-kievirus B5 strains that caused an outbreak of viral encephalitis in Henan, China 显示文摘 | Ma HX Huang XE Kang K | 2013 | Arch Viro12013，158，10： | 1 |
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