|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Amnion epithelial cells——a novel therapy for ischemic stroke?显示文摘Stroke is a leading cause of death and disability and new therapies are desperately needed. Given the complex nature of ischemic brain injury, it has been postulated that cell-based therapies may be useful. However, cell resources, invasive extraction procedures, immunological rejection, tumorigenesis and ethical challenges make it unlikely that many stem cell types could serve as a practical source for therapy. By contrast, these issues do not pertain to human amnion epithelial cells(h AECs), which are placenta-derived stem cells. We recently assessed the effects of systemically delivered hAECs on stroke outcome using four animal models of stroke. We demonstrated that when injected intravenously after ischemia onset, hAECs migrate preferentially to the spleen and injured brain to limit apoptosis and inflammation, and attenuate early brain infiltration of immune cells, progression of infarction and systemic immunosuppression and to ultimately ameliorate functional deficits. When administration of hAECs is delayed by 1-3 days poststroke, long-term functional recovery can still be enhanced in young and aged mice of either sex. Moreover, our proof-of-principle findings suggest that h AECs are effective at limiting post-stroke infarct development in non-human primates. Overall, the results suggest that hAECs could be a viable clinical stroke therapy. | Megan A.Evans Brad R.S.Broughton Grant R.Drummond Henry Ma Thanh G.Phan Euan M.Wallace Rebecca Lim Christopher G.Sobey | 2018 | Neural Regeneration Research2018，13，8： | 4 |
| 2 | North atlantic oscillatiodannular mode: Two paradigms—one phenomenon显示文摘 | John M.Wallace | 2007 | QJR Meteorol Soc2007，，564： | 1 |
| 3 | Comparison of the prognostic value of tumour‐ and patient‐related factors in patients undergoing potentially curative surgery for colon cancer显示文摘 | C. S. D.Roxburgh A. M.Wallace G. K.Guthrie P. G.Horgan D. C.McMillan | 2009 | Colorectal Disease2009，，： | 1 |
| 4 | Mechanical suppression of breast cancer cell invasion and paracrine signaling to osteoclasts requires nucleo-cytoskeletal connectivity显示文摘Exercise benefits the musculoskeletal system and reduces the effects of cancer.The effects of exercise are multifactorial,where metabolic changes and tissue adaptation influence outcomes.Mechanical signals,a principal component of exercise,are anabolic to the musculoskeletal system and restrict cancer progression.We examined the mechanisms through which cancer cells sense and respond to low-magnitude mechanical signals introduced in the form of vibration.Low-magnitude,high-frequency vibration was applied to human breast cancer cells in the form of low-intensity vibration(LIV).LIV decreased matrix invasion and impaired secretion of osteolytic factors PTHLH,IL-11,and RANKL.Furthermore,paracrine signals from mechanically stimulated cancer cells,reduced osteoclast differentiation and resorptive capacity.Disconnecting the nucleus by knockdown of SUN1 and SUN2 impaired LIV-mediated suppression of invasion and osteolytic factor secretion.LIV increased cell stiffness;an effect dependent on the LINC complex.These data show that mechanical vibration reduces the metastatic potential of human breast cancer cells,where the nucleus serves as a mechanosensory apparatus to alter cell structure and intercellular signaling. | Xin Yi Laura E.Wright Gabriel M.Pagnotti Gunes Uzer Katherine M.Powell Joseph M.Wallace Uma Sankar Clinton T.Rubin Khalid Mohammad Theresa A.Guise William R.Thompson | 2020 | Bone Research2020，8，4： | 1 |
| 5 | Myocardial bridging in a young patient with sudden death显示文摘 | DavidCutler John M.Wallace | 2009 | Clin Cardiol2009，，6： | 1 |
| 6 | Space–time correlations in turbulent flow: A review显示文摘This paper reviews some of the principal uses, over almost seven decades, of correlations, in both Eulerian and Lagrangian frames of reference,of properties of turbulent flows at variable spatial locations and variable time instants. Commonly called space–time correlations, they have been fundamental to theories and models of turbulence as well as for the analyses of experimental and direct numerical simulation turbulence data. | James M.Wallace | 2014 | Theoretical & Applied Mechanics Letters2014，4，2： | 0 |
| 7 | Fragile X Messenger Ribonucleoprotein 1(FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice显示文摘Fragile X Messenger Ribonucleoprotein 1(FMR1)gene mutations lead to fragile X syndrome,cognitive disorders,and,in some individuals,scoliosis and craniofacial abnormalities.Four-month-old(mo)male mice with deletion of the FMR1 gene exhibit a mild increase in cortical and cancellous femoral bone mass.However,consequences of absence of FMR1 in bone of young/aged male/female mice and the cellular basis of the skeletal phenotype remain unknown.We found that absence of FMR1 results in improved bone properties with higher bone mineral density in both sexes and in 2-and 9-mo mice.The cancellous bone mass is higher only in females,whereas,cortical bone mass is higher in 2-and 9-mo males,but higher in 2-and lower in 9-mo female FMR1-knockout mice.Furthermore,male bones show higher biomechanical properties at 2mo,and females at both ages.Absence of FMR1 increases osteoblast/mineralization/bone formation and osteocyte dendricity/gene expression in vivo/ex vivo/in vitro,without affecting osteoclasts in vivo/ex vivo.Thus,FMR1 is a novel osteoblast/osteocyte differentiation inhibitor,and its absence leads to age-,site-and sex-dependent higher bone mass/strength. | Padmini Deosthale Julián Balanta-Melo Amy Creecy Chongshan Liu Alejandro Marcial Laura Morales Julita Cridlin Sylvia Robertson Chiebuka Okpara David J.Sanchez Mahdi Ayoubi Joaquín N.Lugo Christopher J.Hernandez Joseph M.Wallace Lilian I.Plotkin | 2023 | Bone Research2023，11，2： | 0 |
| 8 | Materials Design on the Origin of Gap States in a High-κ/GaAs Interface显示文摘Given the demand for constantly scaling microelectronic devices to ever smaller dimensions, a SiO_2 gate dielectric was substituted with a higher dielectric-constant material, Hf(Zr)O_2, in order to minimize current leakage through dielectric thin film. However, upon interfacing with high dielectric constant(high-κ) dielectrics, the electron mobility in the conventional Si channel degrades due to Coulomb scattering, surface-roughness scattering, remotephonon scattering, and dielectric-charge trapping. III-V and Ge are two promising candidates with superior mobility over Si. Nevertheless, Hf(Zr)O_2/III-V(Ge) has much more complicated interface bonding than Si-based interfaces. Successful fabrication of a high-quality device critically depends on understanding and engineering the bonding conflgurations at Hf(Zr)O_2/III-V(Ge) interfaces for the optimal design of device interfaces. Thus, an accurate atomic insight into the interface bonding and mechanism of interface gap states formation becomes essential. Here, we utilize firstprinciple calculations to investigate the interface between HfO_2 and Ga As. Our study shows that As—As dimer bonding, Ga partial oxidation(between 3+ and 1+) and Ga— dangling bonds constitute the major contributions to gap states. These findings provide insightful guidance for optimum interface passivation. | Weichao Wang Cheng Gong Ka Xiong Santosh K.C. Robert M.Wallace Kyeongjae Cho | 2015 | Engineering2015，1，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员