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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | MIMO Wireless Linear Precoding 显示文摘 | M Vu A Paulraj | 2007 | IEEE Signal Processing Magazine (S1053-5888)2007，24，5： | 1 |
| 3 | The barriers to energy efficiency in China: Assessing household electricity saving and consumer behavior in Liaoning Province 显示文摘 | FENG D SOCACOL B K VU K M | 2010 | Energy Policy2010，38，： | 1 |
| 4 | Diagnostic evaluation of patients with a high suspicion of malignancy:comorbidities and clinical predictors of cancer显示文摘 | Weiser MA Cabanillas M Vu K | 2005 | Am J Med Sci2005，330，1： | 1 |
| 5 | Selective formation of para-xylene over H-ZSM-5 coated with polycrystalline sili- calite crystals 显示文摘 | Van Vu D Miyamoto M Nishiyama N | 2006 | Journal of Catalysis2006，243，： | 1 |
| 6 | The Cytomegaloviral Protein pUL138Acts as Potentiator of Tumor Necrosis Factor(TNF)Receptor 1Surface Density To Enhance ULb'-Encoded Mod?lation of TNF-alpha Signaling显示文摘 | Vu T Trilling M Hengel H | 2011 | JOURNAL OF VIROLOGY2011，85，13： | 1 |
| 7 | Brand and product integration in horizontal mergers and ~quisitions 显示文摘 | VU D A SHI Y J GREGORY M | 2010 | European Journal of International Management2010，4，1： | 1 |
| 8 | Evidence for high trans- lational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke 显示文摘 | Eckert M A Vu Q Xie K | 2013 | J Cereb Blood Flow Metab2013，33，9： | 1 |
| 9 | On the capacity of MIMO wireless channels with dynamic CSIT显示文摘 | Vu M Paulraj A | 2007 | IEEE J Sel Areas Com- mun2007，25，7： | 1 |
| 10 | Corrosion-induced cracking : experimental data and predictive models 显示文摘 | Vu K Stewart M G Mullard J | 2005 | ACI Structural Journal2005，102，5： | 1 |
| 11 | Neuroimaging insights into thepathophysiology of sleep disorders 显示文摘 | Desseilles M Dang - Vu T Schabus M | 2008 | Sleep2008，31，6： | 1 |
| 12 | Use of local measurements to estimate voltage-stability margin 显示文摘 | VU K BEGOVIC M NOVOSEL D | 1999 | IEEE Trans on Power Systems1999，14，3： | 1 |
| 13 | RFI Suppression in ultrawideband SAR using an adaptive line enhancer显示文摘 | VU V T SJ?GREN T K PETTERSSON M I | 2010 | IEEE Geoscience and Remote Sensing Letters2010，7，4： | 1 |
| 14 | TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression显示文摘 | Tang B Vu M Booker T | 2003 | J Clin Invest2003，112，7： | 1 |
| 15 | Rosiglitazone and pioglitazone:update on cardiovascular and hepatic adverse reaction 显示文摘 | Vu D Murty M McMorran M | 2002 | Canadian Advers Drug Reaction Newsletter2002，12，： | 1 |
| 16 | Blocking probability for priority classes in optical burst switching networks 显示文摘 | Vu H L Zukerman M | 2002 | IEEE Communications Letters2002，6，5： | 1 |
| 17 | Comparison of llama VH sequences from conventional and heavy chain antibodies显示文摘 | VU K B GHAHROUDI M A WYNS L | 1997 | Mol Immunol1997，34，1617： | 1 |
| 18 | Comparison of Bone and 2-deoxy-2- Fluoro-D-glucose Positron Emission Tomography in the Evaluation of Bony Metastases in Lung Cancer显示文摘 | Gayed I Vu T Johnson M | 2003 | Mol Imaging Biol2003，5，1： | 1 |
| 19 | Does jejunal feeding activate exocrine pancreatic secretion 显示文摘 | Vu MK Van der Veek PP Frolich M | 1999 | Eur J Clin Invest1999，29，： | 1 |
| 20 | Halogen lamp recrystallization of silion on insulating substrates显示文摘 | VU D P HAOND M BENSAHEL D | 1983 | J Appl Phys1983，54，1： | 1 |
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