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	题名	作者	年代	出处	被引量
1	Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation.	Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon	2012	World Journal of Gastrointestinal Oncology2012，4，5：	5
2	Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking显示文摘瞄准:为了调查一个模糊逻辑模型是否能预言肤色,表面的癌症(CRC ) 风险由在世袭 non-polyposis 肤色吸表面的癌症(HNPCC ) 病人产生了。方法:从 Creighton 大学世袭癌症研究所登记的 340 个 HNPCC 失配修理(MMR ) 变化搬运人为当模特儿被选择。年龄依赖者曲线被产生阐明开发 CRC 的概率上的在基因变化(hMLH1 或 hMSH2 ) 之间的联合效果,性,和吸烟地位。结果:在男 hMSH2 变化搬运人的吸烟显著地增加的 CRC 风险(P < 0.05 ) 。hMLH1 变化为男性相对 hMSH2 变化搬运人扩充了 CRC 风险(P < 0.05 ) 。男性们非为 hMLH1 比女性有 CRC 的显著地更高的风险吸烟者(P < 0.05 ) , hMLH1 吸烟者(P < 0.1 ) 并且 hMSH2 吸烟者(P < 0.1 ) 。以在在男性的 hMSH2 的一种剂量依赖者方式的吸烟支持的 CRC (P < 0.05 ) 。有 hMSH2 变化的女性和与 hMLH1 组一起的两性仅仅在广泛的吸烟历史以后表明了吸烟效果(P < 0.05 ) 。结论:由在 HNPCC 病人吸烟的 CRC 提升依赖于基因变化,性和年龄。这些数据证明模糊建模可以启用临床的风险分数的明确的表达,从而允许 CRC 预防策略的 individualization。	Rhonda M Brand David D Jones Henry T Lynch Randall E Brand Patrice Watson Ramesh Ashwathnayaran Hemant K Roy	2006	World Journal of Gastroenterology2006，12，28：	5
3	A double-blind, placebocontrolled trial of sertraline for depressive symptoms in patients with stable,chronic schizophrenis 显示文摘	Mulholland C Lynch G King D J	2003	J Psychopharmacol2003，17，：	1
4	Mass conservation in finite element groundwater models显示文摘	Lynch D	1984	Advances in Water Resources1984，7，2：	1
5	The cracked tooth syndrome显示文摘	Lynch C D McConnell R J	2002	J Can Dent Assoc2002，68，8：	1
6	Lipoxygenase-generated hydroperoxides account for the nonphysiological features of ethylene formation from 1-aminocyclopropane-1-carboxylic acid by microsomal membranes of carnations显示文摘	Lynch D V Sridhara S Thompson J E	1995	Planta1995，164，：	1
7	Lymphomatoid granulomatosis:radiologic features and pathologic correlations显示文摘	Lee JS Tuder R Lynch D	2000	AJR2000，175，11：	1
8	Iron an blood donation 显示文摘	Skikne B Lynch S Borek D	1984	Clin Haematol1984，，：	1
9	查看详情显示文摘	LYNCH B J ZHAO Y TRUHLAR D G		0，，：	1
10	查看详情显示文摘	D W Yoon D E Gross V M Lynch J M Sessler B P Hay C H Lee		0，，：	1
11	The effect of the nitrification inhibitor dicyandiamide (DCD) on herbage production when applied at different times and rates in the autumn and winter显示文摘	O'Connor PJ Hennessy D Brophy C O'Donovan M Lynch MB	2012	Agricultural Ecosystems & Environment2012，152，：	1
12	Electromyographic latency changes in the ankle musculature during inversion moments 显示文摘	Lynch SA Eklund U Gottlieb D	1996	Am J Sports Med1996，24，3：	1
13	Biotransformation of sevoflurane in dogs and rats 显示文摘	Lynch S Napoli M D	1981	Anesth Analg1981，60，：	1
14	Dependence of the stimulated emission cross section of Yb3+on host glass composition显示文摘	Weber M Lynch J Blackburn D	1983	IEEE J Quantum Electronics1983，19，10：	1
15	Myocardial infarction and normal coronary arteriography:a 10 year clinical and risk analysis of 74 patients显示文摘	Raymond R Lynch J Underwood D	1988	J Am Coll Cardiol1988，11，3：	1
16	A New Potential Energy Surface for H2Br and Its Use to Calculate Branching Ratios and Kinetic Isotope Effects for the H+ HBr Reaction显示文摘	LYNCH G C TRUHLAR D G BROWN F B	1995	J Phys Chem1995，，99：	1
17	Internal tide and nonlinear internal wave behavior at the continental slope in the northern South China Sea显示文摘	Duda T F Lynch J F Irish J D	2004	IEEE Journal of Oceanic Engineering2004，29，4：	1
18	Interaction of Iron with Other Nutrients 显示文摘	Scan R Lynch M D	1997	Nutrition Reviews1997，55，4：	1
19	Targeted disruption of the melanocortin-4 receptor results in obesity in mice显示文摘	Huszar D Lynch C A Fairchild H V		0，，01：	1
20	Impact of wild-type and genetically modified Pseudomonas fluorescens on soil enzyme activities and microbial population structure in the rhizosphere of pea显示文摘	Naseby D C Lynch J M	1998	Molecular Ecology1998，7，5：	1

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