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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Recent developments in semiconductor gamma-ray detectors 显示文摘 | Luke P N Amman M TindaU C | 2005 | Journal of Radloanalyrical and Nuclear Chemistry2005，264，1： | 1 |
| 3 | The Associ- ation of Surgical Margins and Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy: A Meta-Analysis显示文摘 | Houssami N Macaskill P Luke Marinovich M | 2014 | Ann Surg Oncol2014，21，3： | 1 |
| 4 | Single - polarity charge sensing in ionization detectors using coplanar electrodes 显示文摘 | Luke P N | 1994 | Appl Phys Lett1994，65，： | 1 |
| 5 | Electrode Configuration and Energy Resolution in Gamma- ray Detectors 显示文摘 | | 1996 | Nucl Instr Meth Phys Res A1996，380，： | 1 |
| 6 | Single- polarity Charge Sensing in Ionization Detectors Using Coplanar Electrodes 显示文摘 | | 1994 | Appl Phys Lett1994，65，： | 1 |
| 7 | Unipolar Charge Sensing with Coplanar Elec- trodes- Application to Semiconductor Detectors 显示文摘 | | 1995 | IEEE Trans Nucl Sci1995，42，4： | 1 |
| 8 | Performance of CdZnTe Coplanar- grid Gamma- Ray Detectors 显示文摘 | | 1996 | IEEE Trans Nucl Sci1996，43，3： | 1 |
| 9 | Coplanar- grid Detector with Single- electrode Readout 显示文摘 | Luke P N | 1997 | Proceeding of SPIE1997，3115，： | 1 |
| 10 | Bone-targeted pyridopyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorption agents显示文摘 | Vu C B Luke G P Kawahata N | 2003 | Bioorg Med Chem Lett2003，13，： | 1 |
| 11 | Degradation of phenol by underwater pulsed corona discharge in combination with TiO2 photocatalysis显示文摘 | P Lukes M Clupek P Sunka F Peterka T Sano N Negishi S Matsuzawa K Takeuchi | 2005 | Research on Chemical Intermediates (-)2005，，4： | 1 |
| 12 | Unipolar charge sensmg with coplanar electrodes; Application to semiconductor detectors 显示文摘 | Luke P N | 1995 | IEEE Transactions on Nuclear Science1995，42，4： | 1 |
| 13 | Electron trapping nonuniformity in high-pressure-Bridg- man-grown CdZnTe显示文摘 | AMMAN M LEE J S LUKE P N | 2002 | J Appl Phys2002，92，6： | 1 |
| 14 | 显示文摘 | Luke P N | 1995 | IEEE Trans Nucl Sci1995，42，4： | 1 |
| 15 | Suicide ideation and attempt in a community cohort of urban Aboriginal youth:A cross-sectional study显示文摘 | Luke J N Anderson I P Gee G J | 2013 | Crisis2013，34，4： | 1 |
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