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| 1 | Enhanced Photoprotection by Protein-Bound vs Free Xanthophyll Pools: A Comparative Analysis of Chlorophyll b and Xanthophyll Biosynthesis Mutants显示文摘当植物吸收的光超过光合作用的能力时,黄色色素 violaxanthin 是 reversibly de-epoxidized 到在所谓的黄色色素周期的玉米黄质。玉米黄质迎着过量光在光合的有机体的保护起一个关键作用,由支持很快可逆(qE ) 并且长期(qI ) 激动的叶绿素熄灭,并且阻止类脂化合物氧化。玉米黄质,免费的任何一个或到轻收获的建筑群(Lhcs ) 的界限的 photoprotective 角色,被使用缺乏 Chl b (ch1 ) 或特定的黄色色素种类的异种调查了(npq, lut2 ) 。ch1 变化原因(1 ) Lhcb 蛋白质的缺席;(2 ) 反馈 de 刺激(qE ) 的强壮的减小;并且(3 ) 是的黄色色素的累积免费颜料进 thylakoids。Ch1 异种在高光显示出极端敏感到相片氧化的应力,由于更高的汗衫氧(1O2 ) 版本。双变异的 ch1npq1 比 ch1 对相片氧化更敏感,证明甚至当时,那玉米黄质确实保护类脂化合物在膜免费。不过,玉米黄质的缺乏在包含 Lhcs 植物(WT 对 npq1 ) 有类脂化合物 peroxidation 诚实的强壮得多的影响关于 Lhc 少些种(ch1 对 ch1npq1 ) ,暗示它的保护的效果被和天线蛋白质的相互作用提高。玉米黄质的抗氧化剂能力面对 PSIILHCsZea 建筑群被授权,这被建议,当它 qE 的改进上的效果仅仅提供次要的贡献时。到外长的 1O2 的 WT 对 npq1 植物的敏感的比较建议除 1O2 清除以外,至少一另外的机制涉及叶绿体 photoprotection。 | Luca Dall'Osto Stefano Cazzaniga Michel Havaux Roberto Bassi | 2010 | Molecular Plant2010，3，3： | 8 |
| 2 | Ectopic expression of the osteogenic master gene RUNX2 in melanoma显示文摘The transcription factor RUNX2 is the osteogenic master gene expressed in mesenchymal stem cells during osteogenic commitment as well as in pre-osteoblasts and early osteoblasts.However,RUNX2 is also ectopically expressed in melanoma and other cancers.Malignant melanoma(MM)is a highly metastatic skin cancer.The incidence of MM has increased considerably in the past half-century.The expression levels and mutation rates of genes such as BRAF,KIT,NRAS,PTEN,P53,TERT and MITF are higher in melanoma than in other solid malignancies.Additionally,transcription factors can affect cellular processes and induce cellular transformation since they control gene expression.Recently,several studies have identified alterations in RUNX2 expression.In particular,the regulation of KIT by RUNX2 and the increased expression of RUNX2 in melanoma specimens have been shown.Melanocytes,whose transformation results in melanoma,arise from the neural crest and therefore show'stemness'features.RUNX2 plays an important role in the re-activation of the MAPK and PI-3K/AKT pathways,thus endowing melanoma cells with a high metastatic potential.In melanoma,the most frequent metastatic sites are the lung,liver,brain and lymph nodes.In addition,bone metastatic melanoma has been described.Notably,studies focusing on RUNX2may contribute to the identification of an appropriate oncotarget in melanoma. | Maria Teresa Valenti Luca Dalle Carbonare Monica Mottes | 2018 | World Journal of Stem Cells2018，10，7： | 2 |
| 3 | Transcription factor Runx2 and its application to hone tissue engineering显示文摘 | Luca Dalle Carbonare L Innamorati G Valenti MT | 2012 | Stem Cell Rev2012，8，3： | 1 |
| 4 | Study of thermal deactivation of a de-NOx commercial catalyst显示文摘 | Isabella Nova Lorenzo dall'Acqua Luca Lietti | 2001 | Applied Catalysis B:Environmental2001，，35： | 1 |
| 5 | Exploring networks with traceroute-like probes: Theory and simulations显示文摘 | Luca Dall’Asta Ignacio Alvarez-Hamelin Alain Barrat Alexei Vázquez Alessandro Vespignani | 2006 | Theoretical Computer Science2006，，1： | 1 |
| 6 | Gene expression analysis in osteoblastic differentiation from peripheral blood mesenchymal stem cells显示文摘 | Maria Teresa Valenti Luca Dalle Carbonare Luca Donatelli Francesco Bertoldo Mirko Zanatta Vincenzo Lo Cascio | 2008 | Bone2008，，6： | 1 |
| 7 | Analysis of Horse Myostatin Gene and Identification of Single Nucleotide Polymorphisms in Breeds of Different Morphological Types显示文摘 | Stefania Dall’Olio Luca Fontanesi Leonardo Nanni Costa Marco Tassinari Laura Minieri Adalberto Falaschini Peter Dovc | 2010 | Journal of Biomedicine and Biotechnology2010，，： | 1 |
| 8 | CRISPR/Cas system: An emerging technology in stem cell research显示文摘The identification of new and even more precise technologies for modifying and manipulating the genome has been a challenge since the discovery of the DNA double helix.The ability to modify selectively specific genes provides a powerful tool for characterizing gene functions,performing gene therapy,correcting specific genetic mutations,eradicating diseases,engineering cells and organisms to achieve new and different functions and obtaining transgenic animals as models for studying specific diseases.Clustered regularly interspaced short palindromic repeats(CRISPR)/Cas9 technology has recently revolutionized genome engineering.The application of this new technology to stem cell research allows disease models to be developed to explore new therapeutic tools.The possibility of translating new systems of molecular knowledge to clinical research is particularly appealing for addressing degenerative diseases.In this review,we describe several applications of CRISPR/Cas9 to stem cells related to degenerative diseases.In addition,we address the challenges and future perspectives regarding the use of CRISPR/Cas9 as an important technology in the medical sciences. | Maria Teresa Valenti Michela Serena Luca Dalle Carbonare Donato Zipeto | 2019 | World Journal of Stem Cells2019，11，11： | 1 |
| 9 | An EPR Study of the Surface Chemistry of the V 2 O 5 –WO 3 /TiO 2 Catalyst: Redox Behaviour and State of V(IV)显示文摘 | Maria Cristina Paganini Lorenzo Dall’Acqua Elio Giamello Luca Lietti Pio Forzatti Guido Busca | 1997 | Journal of Catalysis1997，，2： | 1 |
| 10 | Polyphenolic Composition of Hazelnut Skin显示文摘 | Daniele Del Rio Luca Calani Margherita Dall Asta | 2011 | Journal of Agricultural and Food Chemistry2011，59，： | 1 |
| 11 | Mesenchymal stem cells: A new diagnostic tool?显示文摘Mesenchymal stem cells(MSCs) are progenitor cells capable of self-renewal that can differentiate in multiple tissues and, under specific and standardizedculture conditions, expand in vitro with little phenotypic alterations. In recent years, preclinical and clinical studies have focused on MSC analysis and understanding the potential use of these cells as a therapy in a wide range of pathologies, and many applications have been tested. Clinical trials using MSCs have been performed(e.g., for cardiac events, stroke, multiple sclerosis, blood diseases, auto-immune disorders, ischemia, and articular cartilage and bone pathologies), and for many genetic diseases, these cells are considered an important resource. Considering of the biology of MSCs, these cells may also be useful tools for understanding the physiopathology of different diseases, and they can be used to develop specific biomarkers for a broad range of diseases. In this editorial, we discuss the literature related to the use of MSCs for diagnostic applications and we suggest new technologies to improve their employment. | Maria Teresa Valenti Antonio Mori Giovanni Malerba Luca Dalle Carbonare | 2015 | World Journal of Stem Cells2015，7，5： | 0 |
| 12 | Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem Ⅰfrom Arabidopsis thaliana显示文摘Cyclic electron transport/flow(CET/CEF)in chloroplasts is a regulatory process essential for the optimization of plant photosynthetic efficiency.A crucial CEF pathway is catalyzed by a membrane-embedded NADH dehydrogenase-like(NDH)complex that contains at least 29 protein subunits and associates with photosystem I(PSI)to form the NDH-PSI supercomplex.Here,we report the 3.9Åresolution structure of the Arabidopsis thaliana NDH-PSI(AtNDH-PSI)supercomplex.We constructed structural models for 26 AtNDH subunits,among which 11 are unique to chloroplasts and stabilize the core part of the NDH complex.In the supercomplex,one NDH can bind up to two PSI-light-harvesting complex I(PSI-LHCI)complexes at both sides of its membrane arm.Two minor LHCIs,Lhca5 and Lhca6,each present in one PSI-LHCI,interact with NDH and contribute to supercomplex formation and stabilization.Collectively,our study reveals the structural details of the AtNDH-PSI supercomplex assembly and provides a molecular basis for further investigation of the regulatory mechanism of CEF in plants. | Xiaodong Su Duanfang Cao Xiaowei Pan Lifang Shi Zhenfeng Liu Luca Dall’Osto Roberto Bassi Xinzheng Zhang Mei Li | 2022 | Molecular Plant2022，15，3： | 0 |
| 13 | Loss of CDKN1B induces an age-related clonal hematopoietic disorder via Notch2 activity dysregulation显示文摘Dear Editor,The tumor suppressor gene CDKN1B,encoding for the p27^(Kip1)(p27)protein,defines the smallest region of deletion on chromosome 12p13 described in clonal hematopoietic disorders(CHDs)[1].Among them,myelodysplastic syndromes(MDSs)display typical onset in the elderly and an indolent behavior that may evolve in acute myeloid leukemia(AML)[2].Recent evidences support a model of parallel clonal evolution at the stem or progenitor cell level and implicate the need of more preclinical,translational and clinical research to identify better ways to timely target clones that may evolve toward malignancy[3,4]. | Ilenia Segatto Gian Luca Rampioni Vinciguerra Ilenia Pellarin Alessandra Dall’Acqua Stefania Berton Francesca Citron Sara D’Andrea Giorgia Mungo Davide Viotto Lorena Musco Arianna Di Napoli Maria Antonietta Aloe Spiriti Vincenzo Canzonieri Valter Gattei Andrea Vecchione Barbara Belletti Gustavo Baldassarre | 2023 | Cancer Communications2023，43，7： | 0 |
| 14 | Role of autophagy in bone and muscle biology显示文摘Autophagy in eukaryotic cells is a constitutive process and functions as a homeostatic mechanism; it is up-regulated in response to specific stress stimuli such as starvation, hypoxia and as oxidative stress. In addition to playing a crucial role in adaptive responses to different stimuli, autophagy is also required for intracellular quality control. This second aspect is important to prevent the activation of pathological processes. Autophagy also plays a central role in cellular development and differentiation because it is involved in the regulation of energetic balance. This final aspect is critical for maintaining proper bone and muscle function as well as to prevent any pathological changes. Therefore, identifying new molecular targets involved in autophagy is critical to assure a good quality of life. | Maria Teresa Valenti Luca Dalle Carbonare Monica Mottes | 2016 | World Journal of Stem Cells2016，8，12： | 0 |
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