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| 1 | 基于原发肿瘤表观扩散系数直方图分析预测高级别浆液性卵巢癌患者铂类药物化疗敏感性显示文摘高级别浆液性卵巢癌(HGSOC)是最常见和最致命的卵巢癌组织学亚型,初始肿瘤细胞减灭术后进行一线铂类药物化疗是其标准的治疗方法,但其治疗后复发率高达75%。运用间隔6个月有无复发这一非常简单有效的方法对铂敏感及铂耐药患者进行分类,并能为后续的个体化治疗方案选择提供客观依据。弥散加权成像(DWI)可以利用表观扩散系数(ADC)检测细胞和细胞膜的完整性,以量化水分子在组织中的扩散程度,而基于ADC分析的直方图则可分析肿瘤的生物异质性。该研究通过治疗前阶段HGSOC原发病变全肿瘤区域和全实性肿瘤区域ADC直方图分析,对患者铂类药物的化疗反应予以预测。 | Lu J Li HM Cai SQ 毛咪咪(编译) | 2022 | 中华医学杂志2022，102，3： | 5 |
| 2 | Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN显示文摘AIM To investigate the pathogenic effect ofSEB and D-GalN on liver and the protection ofcyclosporin A, the relationship between hepaticapoptosis and necrosis and the possiblemechanism of acute hepatic necrosis.METHODS After staphylococcal enterotoxin B(SEB ) mixed with D--galactosamine (D-GaiN )were injected intraperitoneally into Balb/c miceand those previously treated with cyclosporin A,blood samples were collected and livers wereisolated at 2, 6, 12 and 24 h. Patterns othepatocellular death were studiedmorphologically and biochemically, circulatingcytokines (TNF-a, IFN--y ) and mice mortalitywithin 24h was assessed.RESU’LTS The SEB could induce the typicalapoptotic changes of hepatocytes, the D-GaiNcould induce hepatocytes apoptosis anddegeneration at the same time, and the micehaving received the SEB + D-GaiN injectionsdeveloped apoptosis at 2 and 6 h, but after 12 hhepatocytes were characterized by severein jury, whereas all the examinations in thecyclosporin A treated mice were normal.CONCLUSION Hepatic cell apoptosis might berelated to necrosis, and massive hepatocyteapoptosis is likely the initiating step of acutehepatic necrosis in mice. The effects induced bySEB and D--GaiN on hepatocytes might bemediated by T cells, and could be prevented bycyclosporin A. | Yin, T Tong, SQ Xie, YC Lu, DY | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 3 | An anatomical study of the recurrent laryngeal nerve:its branching patterns and rela- tionship to the inferior thyroid artery显示文摘 | Sun SQ Zhao J Lu H | 2001 | Surg Radiol Anat2001，23，6： | 1 |
| 4 | DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk 显示文摘 | Xu SQ Lu WH Sun X | 2004 | Cancer Detect Prey2004，28，3： | 1 |
| 5 | Corporate governance and earnings man- agement in Chinese listed companies: A tunneling per- spective 显示文摘 | Liu SQ Lu Z | 2007 | Journal of Corporate Finance2007，13，5： | 1 |
| 6 | Basic fibroblast growth factor - induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR - 1, MAPK/ERK, and transcription factor AP- 1 显示文摘 | Yang H Xia Y Lu SQ | 2008 | J Biol Chem2008，253，9： | 1 |
| 7 | Quantifying the effects of contact duration, loading rate, and approach velocity on P-selectin-PSGL-1 interactions using AFM显示文摘 | Lu SQ Ye ZZ Zhu C | 2006 | Polymer2006，47，： | 1 |
| 8 | Clinical and biological charac- teristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leu- kemia: a case series of a Chinese population 显示文摘 | Xu XQ Wang JM Lu SQ | 2009 | Haematologica2009，94，： | 1 |
| 9 | Investigations on the prevalence, immunodiagnosis and experimental model of giardiasis 显示文摘 | Wang ZY Lu SQ Zhang YQ | 1986 | Chin Med J1986，99，12： | 1 |
| 10 | A simplified probe preparation for ELISA-based NF-KB activity assay显示文摘 | Jin S Lu D Ye SQ | 2005 | J Biochem Biophys Methods2005，65，1： | 1 |
| 11 | Clinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia:a case series of a Chinese popula- tion显示文摘 | Xu XQ Wang JM Lu SQ | 2009 | Haematologiea2009，94，： | 1 |
| 12 | Draft genome of the kiwifruit Actinidia chinensis 显示文摘 | Huang SX Ding J Deng DJ Tang W Sun HH Liu DY Zhang L Niu XL Zhang X Meng M Yu JD Liu J Han Y Shi W Zhang DF Cao SQ Wei ZJ Cui YL Xia YH Zeng HP Bao K Lin L Min Y Zhang H Miao M Tang XF Zhu YZ Sui Y Li GW Sun HJ Yue JY Sun JQ Liu FF Zhou LQ Lei L Zheng XQ Liu M Huang L Song J Xu CH Li JW Ye KY Zhong SL Lu BR He GH Xiao FM Wang HL Zheng HK Fei ZJ Liu YS | 2013 | Nat Commun2013，4，： | 1 |
| 13 | Molecular comparison of Giardia lamblia isolates显示文摘 | Lu SQ Baruch AC Adam RD | 1998 | Int J Parasitol1998，28，9： | 1 |
| 14 | Experience of 1166thyroidectomy without use of prophylactic antibiotic显示文摘 | Lu Q Xie SQ Chen SY | 2014 | Biomed Res Int2014，，： | 1 |
| 15 | Effects of oxymat rine on the antitumor activity and toxicity of cyclophosphamide in mice显示文摘 | Yuan C Lu SQ Yao X | 1987 | Yao Xue Xue Bao1987，22，4： | 1 |
| 16 | Economic evaluation of universal newborn hepatitis B vaccination in China 显示文摘 | Lu SQ McGhee SM Xie X | 2013 | Vaccine2013，31，14： | 1 |
| 17 | Face recognition with radial basis function(rbf)neural networks显示文摘 | Er MJ Wu SQ Lu JW | 2002 | IEEE Transactions on Neural Networks2002，13，3： | 1 |
| 18 | Chlorpyrifos induces delayed cytotoxicity after withdrawal in pri- mary hippocampal neurons through extraceUular signal-regulated kinase inhibition 显示文摘 | Tan DH Peng SQ Wu YL Wang YM Lu CF Ding W | 2009 | Biol Pharm Bull2009，32，10： | 1 |
| 19 | Secondhand smoke (SHS) exposures: workplace exposures, related perceptions of SHS risk, and reactions to smoking in catering workers in smoking and nonsmoking premises 显示文摘 | Lu SQ Fielding R Hedley AJ | 2011 | Nicotine Tob Res2011，13，5： | 1 |
| 20 | Forced dissociation of selectin-ligand complexes using Steered Molecular Dynamics simulation显示文摘 | Lu SQ Long M | 2005 | Mol Cell Biomech2005，2，4： | 1 |
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