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您的检索式：作者名="Louis P.Sandjo"
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| 1 | Isobavachalcone:An Overview显示文摘Isobavachalcone (IBC ) 或(E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)-phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 或(E)-4,2,4-trihydroxy-3-prenylchalcone;2,4,4-trihydroxy-3-prenyl-transchalcone,是班 flavonoid 的 prenylated chalcone,第一在 1968 从 Psoralea 孤立 corylifolia。IBC 被知道拥有大量生物活动,抗菌剂,抗真菌, anticancer,反反向的 transcriptase, antitubercular 和抗氧化剂。混合物从植物家庭被孤立,主要 Moraceae 和 Fabaceae。这评论一起拿出 IBC 上的知识,和罐头为未来研究和物价稳定措施成就用作起点。 | Victor Kuete Louis P.Sandjo | 2012 | Chinese Journal of Integrative Medicine2012，18，7： | 2 |
| 2 | Taxifolin stability: In silico prediction and in vitro degradation with HPLC-UV/UPLCe ESI-MS monitoring显示文摘Taxifolin has a plethora of therapeutic activities and is currently isolated from the stem bark of the tree Larix gmelinni(Dahurian larch). It is a flavonoid of high commercial interest for its use in supplements or in antioxidant-rich functional foods. However, its poor stability and low bioavailability hinder the use of flavonoid in nutritional or pharmaceutical formulations. In this work, taxifolin isolated from the seeds of Mimusops balata, was evaluated by in silico stability prediction studies and in vitro forced degradation studies(acid and alkaline hydrolysis, oxidation, visible/UV radiation, dry/humid heating) monitored by high performance liquid chromatography with ultraviolet detection(HPLC-UV) and ultrahigh performance liquid chromatography-electrospray ionization-mass spectrometry(UPLC-ESI-MS). The in silico stability prediction studies indicated the most susceptible regions in the molecule to nucleophilic and electrophilic attacks, as well as the sites susceptible to oxidation. The in vitro forced degradation tests were in agreement with the in silico stability prediction, indicating that taxifolin is extremely unstable(class 1) under alkaline hydrolysis. In addition, taxifolin thermal degradation was increased by humidity.On the other hand, with respect to photosensitivity, taxifolin can be classified as class 4(stable).Moreover, the alkaline degradation products were characterized by UPLC-ESI-MS/MS as dimers of taxifolin. These results enabled an understanding of the intrinsic lability of taxifolin, contributing to the development of stability-indicating methods, and of appropriate drug release systems, with the aims of preserving its stability and improving its bioavailability. | Fernanda Cristina Stenger Moura Carmem Lúciados Santos Machado Favero Reisdorfer Paula Angelica Garcia Couto Maurizio Ricci Valdir Cechinel-Filho Tiago J.Bonomini Louis P.Sandjo Tania Mari Belle Bresolin | 2021 | Journal of Pharmaceutical Analysis2021，11，2： | 0 |
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