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| 1 | Similar efficacy and safety of tenofovir in Asians and non-Asians with chronic hepatitis B显示文摘AIM:To compare the efficacy and safety of tenofovir disoproxil fumarate(TDF)in Asian and non-Asian chronic hepatitis B(CHB)patients.METHODS:The efficacy and safety of the initial 48wk of treatment with TDF was compared in a posthoc analysis of combined data from 217 Asians and299 non-Asians included in Studies 102 and 103and a post-approval,open-label trial(Study 123).Patient groups were compared according to baseline hepatitis B e antigen(HBe Ag)status and viral load.The main outcome measures included the proportion of patients who achieved a hepatitis B virus(HBV)DNA level<400 copies/m L at Week 48 of treatment.Secondary measures included:HBV DNA and alanine aminotransaminase(ALT)levels over time;proportion of patients with normal ALT levels;proportion of patients with HBe Ag loss/seroconversion and proportion of patients with hepatitis B surface antigen loss/seroconversion;changes in liver histology.Safety and tolerability were evaluated by the occurrence of adverse events(AEs),serious AEs,laboratory abnormalities,discontinuation of the study drug due to AEs,or death.The primary efficacy and safety analysis set included all patients who were randomly assigned to treatment and received at least one dose of study drug.RESULTS:At week 48,similar proportions of Asians and non-Asians reached HBV DNA<400 copies/m L(96%of Asian and 97%of non-Asian patients with HBe Ag-negative CHB and 83%of Asian and 79%of non-Asian patients with HBe Ag-positive CHB had HBV DNA)and normal ALT(78%of Asian and 81%of nonAsian patients with HBe Ag-negative CHB and 71%of Asian and 74%of non-Asian patients with HBe Agpositive CHB had normal ALT).On-treatment HBV DNA decline rates were similar between Asians and nonAsians regardless of baseline HBe Ag status and viralload.HBV DNA decline during the first four weeks was2.9 log10 copies/m L in HBe Ag-negative Asians and nonAsians,and in HBe Ag-positive non-Asians,and 3.1log10 copies/m L in HBe Ag-positive Asians.HBe Ag loss and seroconversion was achieved in 14%of Asians vs 26%and 24%,respectively,in non-Asians.Liver histology improved in 77.2%of Asians and 71.5%of non-Asians.No resistance to TDF developed.No renal safety signals were observed.CONCLUSION:TDF demonstrated similar viral suppression,normalization of ALT,improvements in liver fibrosis,and no detectable resistance in Asian and non-Asian patients regardless of baseline HBe Ag status. | Calvin Q Pan Sing Chan Huy Trinh Alan Yao Ho Bae Lillian Lou | 2015 | World Journal of Gastroenterology2015，21，18： | 4 |
| 2 | Selective detection of HCHO gas using mixed oxides of ZnO/ZnSnO3 显示文摘 | XU J Q JIA X H LOU X D | 2007 | Sensors and Actuators B2007，120，： | 1 |
| 3 | 查看详情显示文摘 | Zhang J P Yang H P Han K L Deng W Q He G Z Lou N Q | | 0，，： | 1 |
| 4 | A highly active bagasse-derived solid acid catalyst with properties suitable for production of biodiesel显示文摘 | LOU W Y GUO Q CHEN W J | 2012 | ChemSusChem2012，5，8： | 1 |
| 5 | Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China显示文摘 | Song Q Wang D Lou Y | 2011 | Diagn Pathol2011，21，6： | 1 |
| 6 | Effect of minor niobium addition on microstructure of a nickel-base directionally solidified superalloy显示文摘 | ZHAO K LOU L H MAY H HU Z Q | 2008 | Materials Science and Engineering A2008，476，12： | 1 |
| 7 | Ultrasonic pulse method for detecting internal defects and cracks in concrete structures显示文摘 | LOU Q X | 1993 | Non-Destructive Testing in Civil Enginecring1993，，2： | 1 |
| 8 | Relations of the laser intensity value, the laser ranging value and the laser incident angle显示文摘 | Cheng X J Tan K Lou Q Y | 2013 | AppliedMechanics and Materials2013，239，： | 1 |
| 9 | Inhibition of the angiogenesis and growth of Alion in human cocorectal cancer in vitro and in vivo显示文摘 | Pan Q Pan H Lou H | 2013 | Cancer Cell International2013，13，1： | 1 |
| 10 | Numerical simulation of steady and unsteady aluminum profile extrusion processes using fi- nite volume method 显示文摘 | Lou S M Zhao G Q Wang R | 2008 | Engineering Computations2008，25，6： | 1 |
| 11 | Effect of heavy metal stress on antioxidative enzymes and liquid peroxidation in leaves and roots of two mangrove plant seedling显示文摘 | Zhang F Q Wang Y S Lou Z P | 2007 | Chemosphere2007，67，： | 1 |
| 12 | Calseques- trin 2 deletion causes sinoatrial node dysfunction and atrial ar- rhythmias associated with altered sarcoplasmic reticulum calci- um cycling and degenerative fibrosis within the mouse atrial pacemaker complexl显示文摘 | Glukhov AV Kalyanasundaram A Lou Q | 2015 | Eur Heart J2015，36，11： | 1 |
| 13 | Oxidation of alcohols catalyzed by a new potassium permanganate adsorbed on graphite reagent 显示文摘 | Lou J D Wang G Q Li L | 2005 | Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry2005，35，4： | 1 |
| 14 | Enzymatic hydrolysis of eater sulphfate in a gyp sum-amended Podzol using an immobilized sulphate in soil organic matter extracts显示文摘 | LOU G Q J WARMAN P R | 1992 | Biology and Fertility of Soils1992，14，4： | 1 |
| 15 | Mining dependency in distributed systems through unstructured logs analysis显示文摘 | Lou J G Fu Q Wang Y | 2010 | Operating Systems Review(ACM)2010，44，1： | 1 |
| 16 | Activation of telomerase by human cytomegalovirus 显示文摘 | Strt K Liu C Rahbar A Zhu Q Liu L Wolmer- Solberg N Lou F Liu Z Shen J Jia J Kyo S Bj6rkholm M Sj6berg J S6derberg-Naucl6r C Xu D | 2009 | J Natl Cancer Inst2009，101，7： | 1 |
| 17 | Analysis and fabrication of corner cube array based on laser direct writing technology显示文摘 | LOU Y WANG H LIU Q | 2010 | Applied Optics2010，49，29： | 1 |
| 18 | Numerical studies on the effects of the lateral boundary on soil-structure interaction in homogeneous soil foundations显示文摘 | LI Z N LI Q S LOU M L | 2005 | Structural Engineering and Mechanics2005，20，4： | 1 |
| 19 | Labile ester sulphfate in organic matter extracted from podzolic soils显示文摘 | LOU G Q J WARMAN P R | 1992 | Biology and Fertility of Soils1992，14，4： | 1 |
| 20 | Right ventricular ar- rhythmogenesis in failing human heart: the role of conduction and repolarization remodeling显示文摘 | LOU Q JANKS D L HOLZEM K M | 2012 | Am J Physiol Heart Circ Physiol2012，303，12： | 1 |
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