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| 1 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 2 | Effects of salvianolic acid-A on NIH/3T3 fibroblast proliferation,collagen synthesis and gene expression显示文摘AIM To investigate the mechanisms ofsalvianolic acid A(SA-A)against liver fibrosisin vitro.METHODS NIH/3T3 fibroblasts were culturedroutinely,and incubated with 10-4mol/L-10-7mol/L SA-A for 22 h.The cell viability wasassayed by[3H]proline incorporation,cellproliferation by[3H]TdR incorporation,cellcollagen synthetic rate was measured with[3H]proline impulse and collagenase digestionmethod.The total RNA was prepared from thecontrol cells and the drug treated cellsrespectively,and α(1)I pro-collagen mRNAexpression was semi-quantitatively analyzedwith RT-PCR.RESULTS 10-4mol/L SA-A decreased cellviability and exerted some cytotoxiciy,while10-5mol/L-10-7mol/L SA-A did not affect cellviability,but inhibited cell proliferationsignificantly,and 10-6mol/L SA-A had the besteffect on cell viability among theseconcentrations of drugs.10-5mol/L-10-6mol/LSA-A inhibited intracellular collagen syntheticrate,but no significant influence on extracellularcollagen secretion.Both 10-5mol/L and10-6mol/L SA-A could decrease α(1)I pro-collagen mRNA expression remarkably.CONCLUSION SA-A had potent action againstliver fibrosis.It inhibited NIH/3T3 fibroblastproliferation,intracellular collagen syntheticrate and type I pro-collagen gene expression,which may be one of the main mechanisms of thedrug. | Liu CH Hu YY Wang XL Liu P Xu LM | 2000 | World Journal of Gastroenterology2000，6，3： | 25 |
| 3 | Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.显示文摘 | Zhang J Liu Q Chen Q Liu NQ Li FL Lu ZB Qin C Zhu H Huang YY He W Zhao BL | 2006 | 中国生物学文摘2006，20，9： | 17 |
| 4 | Protective actions of salvianolic acid A on hepatocyte injured by peroxidation in vitro显示文摘INTRODUCTION Salvianolic radix,one of the most commonly usedtraditional Chinese herbs,was widely studied aboutits actions against liver injury and fibrosis,and wasone of the focuses of recent research.Salvianolic acid-A(SA-A)was an aqueous solublecomponent of Salvianolic radix.In our | Hu YY Liu CH Wang RP Liu C Liu P Zhu DY | 2000 | World Journal of Gastroenterology2000，6，3： | 15 |
| 5 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 6 | Morphology Characteristics of Nd-rich Phase Particles in Melt-quenched Ti-5Al-4Sn-2Zr-1Mo-0.25Si-1Nd Alloy显示文摘The morphology of the melt-equenched Ti-5Al-4Sn-2Zr-1Mo-9.25Si-1Nd alloy is uniformly distributed Nd-rich phase particles in matrix. The particles within grains are spherical, and the particles at grain boundaries are elliptical. The Nd-rich phase particle calculated is 6.6 nm in diameter, which is within the 6-15 nm range of average particle diameter experimentally ob served in the alloy The practical interfsce velocity (0.5 m/s) is much greater than the critical velocity (0.15 m/s), hence the Nd-rich phase particles are trapped by the liquid-solid | LI, GP LI, D LIU, YY HU, ZQ | 1995 | Journal of Materials Science & Technology1995，11，6： | 3 |
| 7 | Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter显示文摘 | Gao DM Wang LF Liu J Kong YY Wang Y Xie YH | 2006 | 中国生物学文摘2006，20，7： | 2 |
| 8 | Association between social support and health outcomes:a meta-analysis 显示文摘 | Wang HH Wu SZ Liu YY | 2003 | Kaohsiung J Med Sci2003，19，7： | 2 |
| 9 | Protective effect of prostaglandin E1 on renal microvascular injury in rats of acute aristolochic acid nephropathy显示文摘 | Sun D Liu CX Ma YY | 2011 | Ren Fail2011，33，2： | 1 |
| 10 | Finite Element Simulation for Estimat- ing the Mechanical Properties of Multi-walled Carbon Nanotubes显示文摘 | Fan CW Liu YY Chyanbin H | 2009 | Applied Physical A: Materials Science and Processing2009，95，3： | 1 |
| 11 | Fetal alloantigen is responsible for the expansion of the CD4(+)CD25(+) regulatory T cell pool during pregnancy显示文摘 | Zhao JX Zeng YY Liu Y | | 0，，02： | 1 |
| 12 | 3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-I through the PI3K/Akt signaling pathway 显示文摘 | Liu Z Zhang YY Zhang QW | 2014 | Anticancer Drugs2014，25，4： | 1 |
| 13 | Annealing hardening in detwinning deformation of Mg-3AHZn alloy显示文摘 | YC Xin XJ Zhou HW Chen JF Nie H Zhang YY Zhang Qg Liu | 2014 | Materials Science and Engineering:A2014，594，： | 1 |
| 14 | Salvianolic acid b ameliorates lipopolysaccharide-induced albumin leakage from rat mesenteric venules through src-regulated transcelluar pathway and paracellular pathway显示文摘 | Pan CS Liu YH Liu YY | 2015 | PLo S One2015，10，01： | 1 |
| 15 | Diameter change of common femoral arteries after percutaneous endovascular aortic repair with the use of the preclose technique显示文摘 | Lin YY Shie RF Liu KS et d | 2014 | J Vasc Surg2014，60，1： | 1 |
| 16 | Immunologic variables in acute mania of bipolar disorders 显示文摘 | Liu HC Yang YY Chou YM | 2004 | J Neuroimmunol2004，105，： | 1 |
| 17 | PTEN tumor sup- pressor plays less prognostic role than P53 tumor suppressor in diffuse large Bcell lymphoma 显示文摘 | Liu YY Yao SN Zhao Y | 2010 | Leuk Lymphoma2010，51，9： | 1 |
| 18 | Effect of dexamethasone on postoperative emesis and pain显示文摘 | Liu K Hsu CC Chia YY | 1998 | Br J Anaesthesia1998，80，： | 1 |
| 19 | Fibmblasts in wound healing: transformation, integrin expression, motility and proliferation differences in syndecan - 1 deficient mice显示文摘 | Jurjus RA Liu YY Pal- Ghosh S | 2007 | Faseb Journal2007，5，21： | 1 |
| 20 | Evolution and the clinical implica- tion mutations in acute myeloid leukemia-stability during disease DNMT3 A 显示文摘 | Hou HA Kuo YY Liu CY | 2012 | Blood2012，119，2： | 1 |
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