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| 1 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 2 | Cloning of two zebrafish cDNA that share domains with the MHC class Ⅱ-associated invariant chain显示文摘 | Yoder J A Harle R N Litman G W | 1999 | Immunogenetics1999，50，： | 1 |
| 3 | Distinct patterns of IgH structure and organization in a divergent lineage of chrondrichthyan fishes 显示文摘 | Amemiya C T Litman R T | 1998 | Immunogenetics1998，47，： | 1 |
| 4 | VH Gene organization in a relict species,the coelacanth Latimeria chalumnae:evolutionary implications 显示文摘 | Ohta Y Litman R T | 1993 | Proc Natl Acad Sci USA1993，90，： | 1 |
| 5 | Predicting Success of Theatrical Movies : An Empirical Study 显示文摘 | Barry R Litman | 1983 | Journal of Popu- lar Culture1983，16，4： | 1 |
| 6 | Anesthesia for tracheal or bronchial foreign body removal in children: an analysis of ninety-four cases显示文摘 | LITMAN R S PONNURI J TROGAN I | 2000 | Anesth Analg2000，91，6： | 1 |
| 7 | Ammonia and urea permeability of mammalian aquaporins显示文摘 | Litman T Sogaard R Zeuthen T | 2009 | Handb Exp Pharmacol2009，，190： | 1 |
| 8 | BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ显示文摘 | Litman R Peng M Jin Z | 2005 | Cancer Cell2005，8，3： | 1 |
| 9 | A long form of the skate IgX gene exhibits a striking resemblance to the new shark IgW and IgNARC genes 显示文摘 | Anderson M K Strong S J Litman R T | 1999 | Immunogenetics1999，49，1： | 1 |
| 10 | Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies 显示文摘 | Potkin SG Litman RE Torres R | 2008 | J Clin Psychopharmacol2008，28，2： | 1 |
| 11 | Predicting the success of Theatrical Movies:An Empirical Study 显示文摘 | Litman Barry R | | Journal of popular culture0，16，4： | 1 |
| 12 | Discourse Segmentation by Human and Automated means显示文摘 | Passonneau R Litman D | | 0，，01： | 1 |
| 13 | A long form of the skate IgX gene exhibits a striking resemblance to the new shark IgW and IgNARC genes 显示文摘 | Strong S J Litman R T | 1999 | Immunogenetics1999，49，： | 1 |
| 14 | The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J ceils 显示文摘 | Peng M Litman R Xie J | 2007 | Embo J2007，26，： | 1 |
| 15 | Ammonia and urea permeability of mammalian aquaporins显示文摘 | Litman T Sogaard R Zeuthen T | 2009 | Handb Exp Pharmacol2009，190，4： | 1 |
| 16 | Breathing patrams and levels of consciousness in children suring administration of nitrous oxide after oral midazolam premedication显示文摘 | LITMAN R S KOTTRA J A BERKOWITZ R J | 2001 | Pediatric Anaesthesia2001，55，10： | 1 |
| 17 | Cloning of two zebrafish cDNAs that share domains with the MHC class II-associated invariant chain显示文摘 | Yoder J A Haire R N Litman G W | 1999 | Immunogenetics1999，50，12： | 1 |
| 18 | Diverse organization of immunoglobulin VH gene loci in a primitive vertebrate 显示文摘 | Litman R Shamblott M J | 1988 | EMBO J1988，7，： | 1 |
| 19 | Pediatric airway foreign body retrieval :surgical and anesthetic perspectives显示文摘 | ZUR K B LITMAN R S | 2009 | Pediatr Anesth2009，19，1： | 1 |
| 20 | Discourse segmentation by human and automated means显示文摘 | PASSONEAU R LITMAN D | 1997 | Computational Linguistics1997，23，1： | 1 |
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