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您的检索式：作者名="Lingchen Fu"
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| 1 | The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury显示文摘Sentrin-specific protease 3(SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication in myocardial ischemia reperfusion(MIR) injury is unclear. Here, we observed that SENP3 was expressed and upregulated in the mouse heart depending on reactive oxygen species(ROS) production in response to MIR injury. By utilizing si RNA-mediated cardiac specific gene silencing, SENP3 knockdown was demonstrated to significantly reduce MIR-induced infarct size and improve cardiac function. Mechanistic studies indicated that SENP3 silencing ameliorated myocardial apoptosis mainly via suppression of endoplasmic reticulum(ER) stress and mitochondrial-mediated apoptosis pathways. By contrast, adenovirusmediated cardiac SENP3 overexpression significantly exaggerated MIR injury. Further molecular analysis revealed that SENP3 promoted mitochondrial translocation of dynamin-related protein 1(Drp1) in reperfused myocardium. In addition, mitochondrial division inhibitor-1(Mdivi-1), a pharmacological inhibitor of Drp1, significantly attenuated the exaggerated mitochondrial abnormality and cardiac injury by SENP3 overexpression after MIR injury. Taken together, we provide the first direct evidence that SENP3 upregulation pivotally contributes to MIR injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury. | Lingchen Gao Yichao Zhao Jie He Yang Yan Longwei Xu Nan Lin Qingqi Ji Renyang Tong Yanan Fu Yu Gao Yuanyuan Su Ancai Yuan Ben He Jun Pu | 2018 | Journal of Genetics and Genomics2018，45，3： | 5 |
| 2 | Prostaglandin E 2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice显示文摘 | Dingzhi Wang Lingchen Fu Haiyan Sun Lixia Guo Raymond N. DuBois | 2015 | Gastroenterology2015，，7： | 1 |
| 3 | auto-activation of c-Jun gene by amino acid deprivation of hepatocellular carcinoma cells reveals a novel c-Jun- mediated signaling pathway显示文摘 | Lingchen Fu Mukundh Balasubramanian Jixiu Shan | 2011 | J Biol Chem2011，286，36： | 1 |
| 4 | iHair Recolorer: deep image-to-video hair color transfer显示文摘In this paper, we present i Hair Recolorer, the first deep-learning based approach for examplebased hair color transfer in videos. Given an input video and a reference image, our method automatically transfers the hair color in the reference image to the hair in the video while keeping other hair attributes(e.g.,shape, structure, and illumination) untouched, producing vivid color-transferred dynamic hair in the video.Our method performs the color transfer purely in the image space, without any form of intermediate 3 D hair reconstruction. The key enabler of our method is a carefully designed conditional generative model that explicitly disentangles various hair attributes into their corresponding sub-spaces, which are implemented as conditional modules integrated into a generator. We introduce a novel spatially and temporally normalized luminance map to represent the structure and illumination of the hair. Such a representation can largely ease the burden of the generator to synthesize temporally coherent vivid dynamic hairs in the video. We further introduce a cycle consistency loss to enforce the faithfulness of the generated results with respect to the reference. We demonstrate our system’s superiority in video hair color transfer by extensive experiments and comparisons to alternative methods. | Keyu WU Lingchen YANG Hongbo FU Youyi ZHENG | 2021 | Science China(Information Sciences)2021，64，11： | 0 |
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