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| 1 | Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Rheumatoid arthritis(RA)is an aggressive autoimmune arthritis,and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects.Low-dose interleukin-2(Ld-IL2)is potentially a therapeutic approach to further improve the disease.This randomized,double-blind,placebo-controlled trial was undertaken to evaluate the efficacy and safety of Ld-IL2 in patients with active RA.Patients were randomly assigned(1:1)to receive Ld-IL2,defined as a dose of 1 million IU,or placebo in a 12-week trial with a 12-week follow-up.Three cycles of Ld-IL2 or placebo were administered subcutaneously every other day for 2 weeks(a total of 7 doses),followed by a 2-week break.All patients received a stable dose of methotrexate(MTX).The primary outcomes were the proportion of patients achieving the ACR20,DAS28-ESR<2.6,and the change from baseline in CDAI or SDAI at week 24.Secondary endpoints included other clinical responses and safety.The primary outcomes were achieved in the perprotocol population.The improvements from baseline in CDAI and SDAI were significantly greater across time points for the LdIL2+MTX group(n=17)than for the placebo+MTX group(n=23)(P=0.018 and P=0.015,respectively).More patients achieved ACR20 response in the Ld-IL2+MTX group than those in the placebo+MTX group at week 12(70.6%vs 43.5%)and at week 24(76.5%vs 56.5%)(P=0.014).In addition,low Treg and high IL-21 were associated with good responses to Ld-IL2.Ld-IL-2 treatment was well-tolerated in this study.These results suggested that Ld-IL2 was effective and safe in RA.ClinicalTrials.gov number:NCT 02467504. | Xiaoying Zhang Miao Miao Ruijun Zhang Xu Liu Xiaozhen Zhao Miao Shao Tian Liu Yuebo Jin Jiali Chen Huixin Liu Xia Zhang Yun Li Yunshan Zhou Yue Yang Ru Li Haihong Yao Yanying Liu Chun Li Yuhui Li Limin Ren Yin Su Xiaolin Sun Jing He Zhanguo Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 7 |
| 2 | Hyperuricemia Accompanied with Changes in the Retinal Microcirculation in a Chinese High-risk Population for Diabetes显示文摘Objective To investigate the association of retinal vascular calibers with hyperuricemia in a middle‐aged and elderly population. Methods A cross‐sectional design was applied in this study and 869 participants aged ≥40 years from a high‐risk group for diabetes were recruited. All participants received the anthropometrical measurements and laboratory tests. Retinal arteriolar and venular caliber of the participants were measured with a semi‐automated system. Hyperuricemia was defined as a serum uric acid level >420 μmol/L in men and >360 μmol/L in women. Linear regression models were used to assess the association of hyperuricemia with retinal vascular calibers. These models were additionally adjusted for age, central obesity, hypertension, dyslipidemia, weekly activity, smoking status, and education. Results Among the 869 participants, 133 (15.3%) suffered from hyperuricemia. The crude mean serum uric acid level was 312.3 μmol/L (Standard Deviation 79.5); mean concentration was 355.0 μmol/L (SD 75.5) in male participants, and 288.0 μmol/L (SD 71.1) in female participants (age‐adjusted difference 58.1 μmol/L, 95% Confidence Internal 48.5, 67.6). After adjusting for additional covariates, male participants with hyperuricemia had 3.77 μm (95% CI ‐0.46, 8.00) smaller arteriolar caliber and 6.20 μm (95% CI 0.36, 12.04) larger venule than those without hyperuricemia; the corresponding numbers among female participants were 1.57 μm (95% CI ‐1.07, 4.21) for retinal arteriolar caliber and 2.28 μm (95% CI ‐1.72, 6.27) for retinal venular caliber. Conclusion Hyperuricemia was associated with smaller retinal arteriolar caliber and larger venular caliber mainly in male participants in this study. | YUAN YuanZhi M. Kamran IKRAM JIANG SunFang LIN HuanDong REN LiMin YAN HongMei SHENG JianHua CHEN XuSheng GAO Xin | 2011 | Biomedical and Environmental Sciences2011，24，2： | 6 |
| 3 | Uncommon EGFR mutations in a cohort of Chinese NSCLC patients and outcomes of first-line EGFR-TKIs and platinum-based chemotherapy显示文摘Objective: Data on the clinical activity of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in patients with non-small-cell lung cancer(NSCLC) and uncommon EGFR mutations remain insufficient.This study aimed to investigate the effect of first-line EGFR-TKIs or platinum-based chemotherapy in NSCLC patients with uncommon EGFR mutations.Methods: We retrospectively enrolled 504 patients with EGFR-mutant NSCLC.The clinical characteristics and treatment outcomes were collected and compared between patients with common and uncommon EGFR-mutant NSCLC.Results: Seventy patients(13.9%) harboring uncommon EGFR mutations were included.Thirty of these patients received EGFR-TKIs and 40 received platinum-based chemotherapy as first-line therapy.The objective response rate(ORR) and median progression-free survival(m PFS) of patients treated with TKIs in the uncommon mutation group was significantly inferior to that in the common mutation group(ORR: 23.3% vs.51.8%,P=0.003; m PFS:7.1 vs.10.9 months,P<0.001).In the uncommon group,m PFS was similar between first-line EGFR-TKIs treatment and platinum-based chemotherapy(7.1 vs.6.1 months,P=0.893).In patients with EGFR G719 X or L861 Q mutations,the m PFS was longer in the first-line EGFR-TKIs treatment group than in the chemotherapy group,but the difference was not statistically significant(G719 X: 8.2 vs.5.8 months,P=0.061; L861 Q: 7.6 vs.4.1 months,P=0.872).Multivariate analyses identified adenocarcinoma(P=0.003) as the independent predictive factor for PFS in patients with uncommon EGFR mutations who were treated with first-line EGFR-TKIs.Conclusions: The current study demonstrated that the effect of first-line EGFR-TKIs was similar to that of platinum-based chemotherapy in patients with uncommon EGFR-mutant NSCLC.Adenocarcinoma was the independent predictive factor for PFS in uncommon EGFR-mutant NSCLC patients treated with first-line EGFRTKIs. | Jinpeng Shi Hui Yang Tao Jiang Xuefei Li Chao Zhao Limin Zhang Sha Zhao Xiaozhen Liu Yijun Jia Yan Wang Lei Xi Shijia Zhang Chunxia Su Shengxiang Ren Caicun Zhou | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 4 | Macroporous Ni foam-supported Co_3O_4 nanobrush and nanomace hybrid arrays for high-efficiency CO oxidation显示文摘Herein, we reported the synthesis of well-defined Co_3O_4 nanoarrays(NAs) supported on a monolithic three-dimensional macroporous nickel(Ni) foam substrate for use in highefficiency CO oxidation. The monolithic Co_3O_4 NAs catalysts were obtained through a generic hydrothermal synthesis route with subsequent calcination. By controlling the reaction time,solvent polarity and deposition agent, these Co_3O_4 NAs catalysts exhibited various novel morphologies(single or hybrid arrays), whose physicochemical properties were further characterized by using several analytical techniques. Based on the catalytic and characterization analyses, it was found that the Co_3O_4 NAs-6 catalyst with nanobrush and nanomace arrays displayed enhanced catalytic activity for CO oxidation, achieving an efficient 100% CO oxidation conversion at a gas hourly space velocity(GHSV) 10,000 hr^(-1) and 150°C with longterm stability. Compared with the other Co_3O_4 NAs catalysts, it had the highest abundance of surface-adsorbed oxygen species, excellent low-temperature reducibility and was rich in surface-active sites(Co^(3+)/Co^(2+)= 1.26). | Shengpeng Mo Hui He Quanming Ren Shuangde Li Weixia Zhang Mingli Fu Limin Chen Junliang Wu Yunfa Chen Daiqi Ye | 2019 | Journal of Environmental Sciences2019，31，1： | 4 |
| 5 | Synthesis, crystal structures and fluorescence properties of four mixed-ligands Zn(Ⅱ) and Cd(Ⅱ) coordination compounds显示文摘Four new coordination compounds, [Zn(dba)(bpy)]n (1), {[Zn(dba)(phen)]·2H2O}n (2), [Cd(dba)(bpy)(H2O)2] (3) and [Cd2(dba)2(phen)2]n (4) (H2dba = 2,5-dihydroxy-p-benzenediacetic acid, bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline) have been prepared via solvothermal method and characterized by sin-gle-crystal X-ray diffraction, infrared spectroscopy, elemental analysis and powder X-ray diffraction. 1 and 2 possess 1D infinite chain structures. Complex 3 exhibits a mononuclear structure. Complex 4 owns binuclear symmetry units, which were bridged via the dba ligands forming a 2D framework. The fluorescence properties of 1―4 have been studied. | ZHAO LiMin, REN Peng, ZHANG ZhenJie, FANG Ming, SHI Wei & CHENG Peng Department of Chemistry, Nankai University, Tianjin 300071, China | 2009 | Science China Chemistry2009，52，9： | 3 |
| 6 | The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosisthrough inhibition of de novo lipogenesis in high-fructose-fed rats显示文摘 | Lu-Ping Ren Guang-Yao Song Zhi-Juan Hu Mingming Zhang Lanbo Peng Shu-Chun Chen Limin Wei Fan Li Wen Sun | 2013 | International Journal of Molecular Medicine2013，，： | 2 |
| 7 | Influence of slug flow on flow fields in a gas–liquid cylindrical cyclone separator:A simulation study显示文摘A simulation method for slug flow based on the VOF multiphase flow model was implemented in ANSYS?Fluent via a user-defined function(UDF)and applied to the dissipation of liquid slugs in the inlet pipe of a gas–liquid cylindrical cyclone(GLCC)separator while varying the expanding diameter ratio and angle of inclination.The dissipation of liquid slug in inlet pipe is analyzed under different expanding diameter ratios and inclination angles.In the inlet pipe,it is found that increasing expanding diameter ratio and inclination angle can reduce the liquid slug stability and enhancing the effect of gravity,which is beneficial to slug flow dissipation.In the cylinder,increasing the expanding diameter ratio can significantly reduce the liquid carrying depth of the gas phase but result in a slightly increase of the gas content in the liquid phase space.Moreover,increasing the inclination angle results in a decrease in the carrying depth of liquid in the vapor phase,but enhances gas–liquid mixing and increases the gas-carrying depth in the liquid phase.Taking into consideration the dual effects of slug dissipation in the inlet pipe and carrying capacity of gas/liquid spaces in the cylinder,the optimal expanding diameter ratio and inclination angle values can be determined. | Xiaoming Luo Jing Ren Tong Chen YibinWang Yuling Lü Limin He | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 2 |
| 8 | Immersing Treatment of Steel Plate Surface in Steel-Aluminum Solid to Liquid Bonding显示文摘The interfacial status of the steel-aluminum solid to liquid bonding plates (their steel plate surfaces were or were not immersed in flux aqueous solution) were measured by using SEM (Scanning Electron Microscope) and X-ray diffraction . The results showed that the layer of flux (the minimum thickness was 15 μm on the steel plate surface) could protect the steel plate surface from oxidizing effectively at high temperature in solid to liquid bonding. The melt temperatUre of the flux should be lower than 580 ℃ so that it could be melted and removed completely. No. 1 flux (patent product made by the author) made up of halogeindes could also force liquid aluminum to infiltrate into steel plate surface and thus the interfacial shear strength of the bonding plate was rather large. | Peng Zhang Yunhui Du Xueping Ren Yonglin Kang Hanwu Liu Jianzhong Cui Limin Ba (Material Science and Engineering School, University of Science and Technique Beijing, Beijing 100083, China)(Metal Forming Department Northeastern University, Shenyang 1 | 1999 | International Journal of Minerals,Metallurgy and Materials1999，13，1： | 2 |
| 9 | Impacts of nano-scale pore structure and organic amine assembly in porous silica on the kinetics of CO_(2) adsorptive separation显示文摘Nano structure including pore structure and amine assembly is critical for improving sorption and desorption kinetics for adsorptive CO_(2) separation.The present work delineates(1)the influence of the nano-scale pore structure of amine-functionalized solid sorbents,and(2)effect of changing the assembly of amine molecules on surface of nano-porous SiO_(2) on the rates of adsorption and desorption of CO_(2).50PEI-MSN sorbent with inverted cone-shaped pores was prepared by using mesoporous silica nanospheres(MSN)with inverted cone-shaped pores for the loading of polyethyleneimine(PEI).Co-structure-directing(CSD)method was used to synthesize the sorbent with arranged amine assembly at nano-scale(2N-CSD).By comparison with 50PE卜SBA15 as a benchmark sorbent,both sorbents have improved sorption and desorption kinetics.There are significant effects of nano pore structure and amine assembly on the sorption and desorption kinetics.The inverted cone-shaped pores in MSN allow loading polymeric amines in their narrower ends and leaving larger pore mouths open for the transport of CO_(2);50PEI-MSN shows a maximum sorption rate of 81.4 mg·g^(-1)·min^(-1) with average sorption rate of 25.4mg·g^(-1)·min^(-1) at 80℃ which are 34%and 59%higher than the corresponding values for 50PEI-SBA15;a maximum desorption rate of 38.4mg·g^(-1)·min^(-1) with average desorption rate of 11.8 mg·g^(-1)·min^(-1) ramping from 30 to 95℃ which are 37%and 156%higher than the corresponding values for 50PEI-SBA15.The arranged monolayer-like amine assembly on surface of nanoporous SiO_(2) likely provides high amine sorption sites through improved accessibility of amine,and 2N-CSD shows a maximum sorption rate of 60.5 mg·g^(-1)·min^(-1),with average sorption rate of 12.8mg·g^(-1)·min^(-1) at 300C which are 108%and 205%higher than the corresponding values for 50PEI-SBA15;a lower maximum desorption rate of 9.7 mg g'1min'1 and average desorption rate of 9.8mg·g^(-1)·min^(-1) ramping from 30 to 95℃ which is 250%higher than the corresponding value for 50PEI-SBA15.The present work demonstrates the importance of tailoring nano-scale pore structure and amine assembly for significantly improving sorption and desorption kinetics of adsorptive CO_(2) separation. | Feijian Lou Guanghui Zhang Limin Ren Xinwen Guo Chunshan Song | 2021 | Nano Research2021，14，9： | 2 |
| 10 | ESCRT-Ⅲ component OsSNF7.2 modulates leaf rolling by trafficking and endosomal degradation of auxin biosynthetic enzyme OsYUC8 in rice显示文摘The endosomal sorting complex required for transport(ESCRT)is highly conserved in eukaryotic cells and plays an essential role in the biogenesis of multivesicular bodies and cargo degradation to the plant vacuole or lysosomes.Although ESCRT components affect a variety of plant growth and development processes,their impact on leaf development is rarely reported.Here,we found that OsSNF7.2,an ESCRT-Ⅲ component,controls leaf rolling in rice(Oryza sativa).The Ossnf7.2 mutant rolled leaf 17(rl17)has adaxially rolled leaves due to the decreased number and size of the bulliform cells.OsSNF7.2is expressed ubiquitously in all tissues,and its protein is localized in the endosomal compartments.OsSNF7.2 homologs,including OsSNF7,OsSNF7.3,and OsSNF7.4,can physically interact with OsSNF7.2,but their single mutation did not result in leaf rolling.Other ESCRT complex subunits,namely OsVPS20,OsVPS24,and OsBRO1,also interact with OsSNF7.2.Further assays revealed that OsSNF7.2 interacts with OsYUC8 and aids its vacuolar degradation.Both Osyuc8and rl17 Osyuc8 showed rolled leaves,indicating that OsYUC8 and OsSNF7.2 function in the same pathway,conferring leaf development.This study reveals a new biological function for the ESCRT-Ⅲcomponents,and provides new insights into the molecular mechanisms underlying leaf rolling. | Liang Zhou Saihua Chen Maohong Cai Song Cui Yulong Ren Xinyue Zhang Tianzhen Liu Chunlei Zhou Xin Jin Limin Zhang Minxi Wu Shuyi Zhang Zhijun Cheng Xin Zhang Cailin Lei Qibing Lin Xiuping Guo Jie Wang Zhichao Zhao Ling Jiang Shanshan Zhu Jianmin Wan | 2023 | Journal of Integrative Plant Biology2023，65，6： | 1 |
| 11 | A joint call for actions to advance taxonomy in China显示文摘Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China. | Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin Ge Jun Chen Yibo Hu Xuming Zhou Gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha Qiang Lin Meng Qu Jianping Jiang Jiatang Li Jing Che Xuelong Jiang Xiaoyong Chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su Chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu Hu Li Huaijun Xue Zhen Ye Xuexin Chen Pu Tang Shujun Wei Hong Pang Qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou Chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei Yin Wu Dai Cong Wei Xiaolei Huang Jingxian Liu Xiangsheng Chen Tianci Yi Zhisheng Zhang Zhulidezi Aishan Qin Li Hongying Hu | 2022 | Zoological Systematics2022，47，3： | 1 |
| 12 | Designed Copper-Amine Complex as an Efficient Template for One-Pot Synthesis of Cu-SSZ-13 Zeolite with Excellent Activity for Selective Catalytic Reduction of NOx by NH3 显示文摘 | Ren Limin Zhu Longfeng Chen Yanmei | 2011 | Chem Commun2011，47，35： | 1 |
| 13 | Organo- template-free and seed-directed synthesis of ZSM-34 zeolite with good performance in methanol-to-olefins显示文摘 | Yang Chengguang Ren Limin Zhang Haiyan | 2012 | J Mater Chem2012，22，12： | 1 |
| 14 | Efficient and stable solid acid catalysts synthesized from sulfonation of swelling mesoporous polydivinylbenzenes显示文摘 | Fujian Liu Xiangju Meng Yonglai Zhang Limin Ren Faisal Nawaz Feng-Shou Xiao | 2010 | Journal of Catalysis2010，，1： | 1 |
| 15 | Effect of Different Thawing Methods on Post-thaw Motility of Cow Semen in Cryopreservation Straws显示文摘The study was to investigate the effects of different thawing temperatures(5,15,40,75,90 ℃) and times(1- 120 s) on properties of post-thaw cow semen by detecting frozen-thawed semen motility,acrosome integrity and tail membrane integrity,further obtaining the optimal thawing method of straw frozen semen from dairy cow. The results showed that(1) Thawing of the straw frozen semen of dairy cow at 75 ℃ for 3 s yielded the highest semen motility,followed by 40 ℃for 20 s,and the least by low temperature 5 ℃ and room temperature 15 ℃ with a semen motility of 0. 3,moreover thawing at high temperature 90 ℃ was not suitable for large scale production due to the difficult control of the temperature;(2) The acrosome intact rate and plasma membrane integrity rate of semens thawed at90 ℃ were remarkably lower than that at 40 ℃ and 75 ℃ significantly(P < 0. 05),while its semen malformation rate was significantly higher than that at 40 ℃and 75 ℃(P < 0. 05);(3) The Survival time of semens at 37 ℃ varied largely among different thawing temperature,in detail by 40 ℃ > 75 ℃ > 90 ℃. In practice,the thawing method of straw frozen semen of dairy cow should be selected according to the specific circumstance and inseminated immediately,with the recommended condition of thawing at 75 ℃ for 3 s. If the thawed semen could not be inseminated immediately,the thawing should be performed at 20 s for 40 ℃to maintain the motility for a longer term. | Qiao Limin Guo Tong Qiao Fuqiang Yao Hua Xiao Xishan Hou Yinxu Fu Jingtao Ren Kang | 2014 | Animal Husbandry and Feed Science2014，6，4： | 1 |
| 16 | High-Tcmpcraturc Synthesis of Stable and Ordered Mcsoporous Polymer Monoliths with Low Diclcctric Constants 显示文摘 | LIU Fujian LI Caijin REN Limin ct al | 2009 | J Mater Chcm2009，19，： | 1 |
| 17 | Surface form inspection with contact coordinate measurement:a review显示文摘Parts with high-quality freeform surfaces have been widely used in industries,which require strict quality control during the manufacturing process.Among all the industrial inspection methods,contact measurement with coordinate measuring machines or computer numerical control machine tool is a fundamental technique due to its high accuracy,robustness,and universality.In this paper,the existing research in the contact measurement field is systematically reviewed.First,different configurations of the measuring machines are introduced in detail,which may have influence on the corresponding sampling and inspection path generation criteria.Then,the entire inspection pipeline is divided into two stages,namely the pre-inspection and post-inspection stages.The typical methods of each sub-stage are systematically overviewed and classified,including sampling,accessibility analysis,inspection path generation,probe tip radius compensation,surface reconstruction,and uncertainty analysis.Apart from those classical research,the applications of the emerging deep learning technique in some specific tasks of measurement are introduced.Furthermore,some potential and promising trends are provided for future investigation. | Yijun Shen Jieji Ren Nuodi Huang Yang Zhang Xinquan Zhang Limin Zhu | 2023 | International Journal of Extreme Manufacturing2023，5，2： | 1 |
| 18 | H_(3)PO_(4) activated biochars derived from different agricultural biomasses for the removal of ciprofloxacin from aqueous solution显示文摘Biochars were prepared by the pyrolysis of various H_(3)PO_(4) activated agricultural biomasses at 600℃and subsequently used as adsorbents for the removal of ciprofloxacin(CIP)from aqueous solution.Peanut shell-based biochar(PSBC),corncob-based biochar(CCBC)and cotton-based biochar(CTBC)had high surface areas(571.0-1006.3 m^(2)/g),well-developed pore structures(mesopores with large pore volumes)and available adsorption functional groups(C=C,C-N and C-O-C).The CIP adsorption onto the biochars was investigated by batch experiments(kinetics,isotherms,thermodynamics,pH,etc.).Thermodynamics calculations showed the spontaneous(ΔG^(θ)<0)and endothermic(ΔH^(θ)>0)nature of the mechanism.In particular,CCBC exhibited high adsorption capacity(120.6 mg/g)of CIP in real lake water and it also had significant removal efficiency of other common pharmaceutical contaminants from real lake environ-ment,and even in a coexisting quintuple system.Finally,multiple interaction mechanisms of CIP adsorption onto aromatized biochar were explored combining characterization analysis and theoretical calculations.Elucidation of the mechanism of CIP adsorption onto biochar provides new insights into the assessment of the removal of pharmaceuticals from the aqueous environment. | Jinbo Ouyang Jian Chen Wenqian Chen Limin Zhou Di Cai Cong Ren | 2023 | Particuology2023，，4： | 0 |
| 19 | Review on Pond Aquaculture Tail Water Treatment Technologies显示文摘Carrying out the treatment of aquaculture tail water and realizing the discharge and recycling of the aquaculture tail water are the inevitable trend in the development of the fishery industry at present and in the future.For this reason,this paper reviewed the characteristics of pond aquaculture tail water,the sources of pollutants in intensive aquaculture tail water,the important parameters in the water body that affect the growth of cultured organisms,and the water treatment methods in the process of aquaculture,and prospected from the technical level and industrial policy level,hoping to accumulate data for promoting the green development of aquaculture and cleaner production. | Shunlong MENG Lihua REN Xi CHEN Liping QIU Chao SONG Limin FAN Dandan LI Jiazhang CHEN Pao XU | 2022 | Agricultural Biotechnology2022，11，2： | 0 |
| 20 | Core-drilling kinematic modeling and analysis of Jiaolong submersible manipulator显示文摘The complicated topographies of the deep sea pose significant challenges for the core drilling with the Jiaolong submersible manipulator.To address this problem,we proposed a core-drilling kinematic model and evaluated the core-drilling behavior of the submersible manipulator by comprehensively considering the uncertain posture of the Jiaolong submersible.First,we established a forward kinematic model for the core-drilling task in deep sea,which satisfied the requirement of gravitational-direction core drilling.Based on the forward kinematic equations,we then built a double-redundancy inverse kinematic model,which was able to determine the required motion trajectories of six active joints according to the desired core-drilling trajectory.The core-drilling workspaces and the motions of the Jiaolong submersible manipulator were assessed with several calculation examples.The established forward and inverse kinematic models are constructed with clear analytic equations,and thus are directly applicable to the Jiaolong submersible manipulator-based core-drilling task. | Xu YANG Xin LIU Shizhen LI Yugang REN Limin ZHU | 2023 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2023，24，11： | 0 |
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