|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells显示文摘IL-37 是仅仅最近被识别的反煽动性的 cytokine,并且它高度与煽动性、自体免疫的疾病从病人在纸巾被表示。煽动性的 cytokines 和煽动性的刺激能导致 IL-37 的 upregulation。然而,反煽动性的药是否导致 IL-37 的表示,没被报导。在这个工作,第一次,我们揭开了那主要 bioactive 二个部件, triptolide 和 triptonide,从植物 Tripterygium wilfordii 钩 f。(TwHF ) ,它拥有反煽动性的活动, upregulate IL-37 的表示,和这表情被 ERK1/2 和 p38 MAPK 禁止者压制。总的来说,第一次,我们的研究表明了那反煽动性的活跃部件(triptolide 和 triptonide ) upregulated 经由 ERK1/2 和 p38 MAPK 小径的激活最可能的 IL-37 的表示。 | Lingge He Zhuangyan Liang Fuqian Zhao Lifei Peng Zhangquan Chen | 2015 | Cellular & Molecular Immunology2015，12，4： | 14 |
| 3 | A large volume cubic press with a pressure-generating capability up to about 10?GPa显示文摘 | Xi Liu Jinlan Chen Junjie Tang Qiang He Sicheng Li Fang Peng Duanwei He Lifei Zhang Yingwei Fei | 2012 | High Pressure Research2012，，2： | 1 |
| 4 | Experimental Investigation on Macro Spray Characteristics of Octanol-Biodiesel-Diesel Ternary Fuel Blend显示文摘This study investigates the spray characteristics of ternary blends composed of octanol, biodiesel, and diesel fuel.Experiments are conducted using six materials to examine the variation in spray characteristic and to verify and compare a previously established spray tip penetration model with a modified model. The results show that the addition of OB100(30%of octanol, 70% of biodiesel) improves the spray characteristics of the fuel. Specifically, the addition of 10% or 20% of OB100 leads to a slight increase in the spray tip penetration, average spray cone angle, maximum spray width, and the spray area of the fuel blend;however, further addition of OB100 causes a corresponding decrease in these parameters. Based on previous research, this study uses kinematic viscosity instead of dynamic viscosity and density to modify the prediction model of spray tip penetration. The modified model exhibits a better fit quality and agreement with the experimental data,making it more suitable for predicting the spray tip penetration of fuel blends compared to the Hiroyasu-Arai model. | Tian Junjian Qiu Zhicong Zhao Lifei Li Fengyu Hu Peng Lin Qizhao | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，4： | 0 |
| 5 | First experimental comparisons of laser-plasma interactions between spherical and cylindrical hohlraums at SGⅢ laser facility显示文摘We present our recent laser-plasmas instability(LPI)comparison experiment at the SGIII laser facility between the spherical and cylindrical hohlraums.Three kinds of filling are considered:vacuum,gas-filling with or without a capsule inside.A spherical hohlraum of 3.6 mm in diameter,and a cylindrical hohlraum of 2.4 mm?4.3 mm are used.The capsule diameter is 0.96 mm.A flat-top laser pulse with 3 ns duration and up to 92.73 kJ energy is used.The experiment has shown that the LPI level in the spherical hohlraum is close to that of the outer beam in the cylindrical hohlraum,while much lower than that of the inner beam.The experiment is further simulated by using our 2-dimensional radiation hydrodynamic code LARED-Integration,and the laser back-scattering fraction and the stimulated Raman scatter(SRS)spectrum are post-processed by the high efficiency code of laser interaction with plasmas HLIP.According to the simulation,the plasma waves are strongly damped and the SRS is mainly developed at the plasma conditions of electron density from 0.08 n_(c) to 0.1 n_(c) and electron temperature from 1.5 keV to 2.0 keV inside the hohlraums.However,obvious differences between the simulation and experiment are found,such as that the SRS back-scattering is underestimated,and the numerical SRS spectrum peaks at a larger wavelength and at a later time than the data.These dif-ferences indicate that the development of a 3D radiation hydrodynamic code,with more accurate physics models,is mandatory for spherical hohlraum study. | Yaohua Chen Zhichao Li Xufei Xie Chunyang Zheng Chuanlei Zhai Liang Hao Dong Yang Wenyi Huo Guoli Ren Jie Liu Xiaoshi Peng Tao Xu Yulong Li Sanwei Li Zhiwen Yang Liang Guo Lifei Hou Yonggang Liu Huiyue Wei Xiangming Liu Weiyi Cha Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Haijun Zhang Baibin Jiang Wei Zhang Kai Du Xuewei Deng Yongkun Ding Xiaofeng Wei Wanguo Zheng Xiaodong Chen Xiantu He Ke Lan | 2017 | Matter and Radiation at Extremes2017，2，2： | 0 |
| 6 | The effects of incident light wavelength difference on the collective stimulated Brillouin scattering in plasmas显示文摘The first laser–plasma interaction experiment using lasers of eight beams grouped into one octad has been conducted on the Shenguang Octopus facility.Although each beam intensity is below its individual threshold for stimulated Brillouin backscattering(SBS),collective behaviors are excited to enhance the octad SBS.In particular,when two-color/cone lasers with wavelength separation 0.3 nm are used,the backward SBS reflectivities show novel behavior in which beams of longer wavelength achieve higher SBS gain.This property of SBS can be attributed to the rotation of the wave vectors of common ion acoustic waves due to the competition of detunings between geometrical angle and wavelength separation.This mechanism is confirmed using massively parallel supercomputer simulations with the three-dimensional laser–plasma interaction code LAP3D. | Qiang Wang Zhichao Li Zhanjun Liu Tao Gong Wenshuai Zhang Tao Xu Bin Li Ping Li Xin Li Chunyang Zheng Lihua Cao Xincheng Liu Kaiqiang Pan Hang Zhao Yonggang Liu Bo Deng Lifei Hou Yingjie Li Xiangming Liu Yulong Li Xiaoshi Peng Zanyang Guan Qiangqiang Wang Xingsen Che Sanwei Li Qiang Yin Wei Zhang Liqiong Xia Peng Wang Xiaohua Jiang Liang Guo Qi Li Minqing He Liang Hao Hongbo Cai Wudi Zheng Shiyang Zou Dong Yang Feng Wang Jiamin Yang Baohan Zhang Yongkun Ding Xiantu He | 2023 | Matter and Radiation at Extremes2023，8，5： | 0 |
| 7 | Dual ultrasound-guided totally implantable venous access ports via the right internal jugular vein in pediatric patients with cancer:a preliminary experience in a single institution显示文摘Objective To assess the efficacy and safety of dual ultrasound-guided(DUG)totally implantable venous access port(TIVAP)implantation(namely,using ultrasoundguided percutaneous puncture with transesophageal echocardiography-guided catheterization)via the right internal jugular vein(IJV)in pediatric patients with cancer.Methods Fifty-five children with cancer requiring chemotherapy underwent DUG-TIVAP implantation via the right IJV.Clinical data were recorded,including the procedure success rate,first attempt success rate,and perioperative and postoperative complications.Results All 55 cases were successfully operated on.The first puncture success rate was 100%.The operation time was 22–41min,with a mean time of 30.8±5.5min.The mean TIVAP implantation time was 253±145 days(range 42–520 days).There were no perioperative complications.The postoperative complication rate was 5.4%(3/55),including skin infections around the port in one case,catheter-related infection in one case,and fibrin sheath formation in one case.The ports were all preserved after anti-infection or thrombolytic therapy.No unplanned port withdrawal was recorded in this study.Conclusions DUG-TIVAP implantation is a technique with a high success rate and a low complication rate;therefore,it provides an alternative for children with cancer.Further randomized controlled studies are needed to confirm the efficacy and safety of DUG-TIVAP via the right IJV in children. | Xiao Bin Deng Liang Peng Jun Zhang Xiangru Kong Zhenzhen Zhao Shan Wang Changchun Li Yifei Du Jianwu Zhou Lifei Liu Chao Yang | 2023 | World Journal of Pediatric Surgery2023，6，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员