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| 1 | Cycling and the Built Environment:A US Perspective显示文摘 | Moudon A V Lee C Cheadle A D Collier C W Johnson D Schmid T L Weather R D | 2005 | Transportation Research Part D2005，，10： | 1 |
| 2 | A high-throughput screen to identify LRRK2 kinase inhibitors for the treatment of Parkinson's disease using RapidFire mass spectrometry 显示文摘 | Melanie Leveridge Lee Collier | 2015 | J Biorrml Screen2015，21，2： | 1 |
| 3 | pH-dependent perforation of macrophage phagosomes by Listeriolysin O from Listeria monocytogenes显示文摘 | Beauregard KE Lee KD Collier RJ | 1997 | J Exp Med1997，186，7： | 1 |
| 4 | Cycling and the Built Environment: A US Perspective显示文摘 | Moudon A V Lee C Cheadle A D Collier C W Johnson D Sehmid T L Weather R D | 2005 | Transportation Research Part D2005，，10： | 1 |
| 5 | Cycling and the Built Environment:A US Perspective显示文摘 | Vernez Moudon A Lee C Cheadle A Collier C Johnson D Schmid T Weather R | 2005 | Transportation Research D2005，10，3： | 1 |
| 6 | Economic production as chemistry显示文摘 | Padgett F J lee D Collier N | 2004 | Industrial and Corporate Change2004，12，： | 1 |
| 7 | Sheet resistance measurement of thin metallic films and stripes at both 130 GHz and DC显示文摘 | LEE M H J COLLIER R J | 2005 | Instrumentation and Measurement IEEE Transactions2005，54，： | 1 |
| 8 | The sheet resistance of thin metallic films and stripes at both DC and 130 GHz显示文摘 | LEE M H J COLLIER R J | 2004 | Microelectronic Engineering2004，7374，： | 1 |
| 9 | An unexplained 10–40° shift in the location of some diverse neutral atom data at 1 AU显示文摘 | Michael R Collier Thomas E Moore David Simpson Aaron Roberts Adam Szabo Stephen Fuselier Peter Wurz Martin A Lee Bruce T Tsurutani | 2004 | Advances in Space Research2004，，1： | 1 |
| 10 | Synthesis and preliminary evaluation of novel^(11)C-labeled GluN2B-selective NMDA receptor negative allosteric modulators显示文摘N-methyl-D-aspartate receptors(NMDARs)play critical roles in the physiological function of the mammalian central nervous system(CNS),including learning,memory,and synaptic plasticity,through modulating excitatory neurotransmission.Attributed to etiopathology of various CNS disorders and neurodegenerative diseases,GluN2B is one of the most well-studied subtypes in preclinical and clinical studies on NMDARs.Herein,we report the synthesis and preclinical evaluation of two^(11)C-labeled GluN2B-selective negative allosteric modulators(NAMs)containing N,N-dimethyl-2-(1H-pyrrolo[3,2-b]pyridin-1-yl)acetamides for positron emission tomography(PET)imaging.Two PET ligands,namely[^(11)C]31 and[^(11)C]37(also called N2B-1810 and N2B-1903,respectively)were labeled with[^(11)C]CH3I in good radiochemical yields(decay-corrected 28%and 32%relative to starting[^(11)C]CO_(2),respectively),high radiochemical purity(>99%)and high molar activity(>74 GBq/μmol).In particular,PET ligand[^(11)C]31 demonstrated moderate specific binding to GluN2B subtype by in vitro autoradiography studies.However,because in vivo PET imaging studies showed limited brain uptake of[^(11)C]31(up to 0.5 SUV),further medicinal chemistry and ADME optimization are necessary for this chemotype attributed to low binding specificity and rapid metabolism in vivo. | Ji-yun Sun Katsushi Kumata Zhen Chen Yi-ding Zhang Jia-hui Chen Akiko Hatori Hua-long Fu Jian Rong Xiao-yun Deng Tomoteru Yamasaki Lin Xie Kuan Hu Masayuki Fujinaga Qing-zhen Yu Tuo Shao Thomas Lee Collier Lee Josephson Yi-han Shao Yun-fei Du Lu Wang Hao Xu Ming-rong Zhang Steven H Liang | 2021 | Acta Pharmacologica Sinica2021，42，3： | 0 |
| 11 | 化纤及其产品的贸易格局正在改变显示文摘虽说未来的化纤生产领域将逐渐被中国和亚洲其他国家所主导,但仍有部分产品亚洲化纤生产商是不具备能力涉足的,这部分产品依然由欧洲和北美的化纤生产商控制。针对这一由欧洲和北美生产商控制的市场,应利用化纤产品的核心创新技术,并联合当地相关方面的专家学者进行不断的研究和开发。 | N. Bywater D. Collier C. Nava R. Lee 李刚 | 2009 | 国际纺织导报2009，37，2： | 0 |
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