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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Utility of balanced steady-state free precession MR venography in the diagnosis of lowerextremity deep venous thrombosis 显示文摘 | Lindquist CM Karlicki F Lawrence P | 2010 | AJR Am J Roentgenol2010，194，5： | 1 |
| 3 | Variability in the in expression of ma- ternal behaviour in primiparous sheep : effects of genotype and litter size 显示文摘 | DWYER CM LAWRENCE AB | 1998 | Applied animal behaviour science1998，58，： | 1 |
| 4 | Halo eczema-resolution after excision of the central naevus alone显示文摘 | Cox NH Bloxham CA Lawrence CM | 1991 | Clin Exp Dermatol1991，16，1： | 1 |
| 5 | Three-dimensional computed tomography of acetabular fracture显示文摘 | Lawrence DB Dona CM Willian HK | 1985 | Radiology1985，155，： | 1 |
| 6 | Crystal structure of the ectodomain of human transferrin receptor 显示文摘 | Ray S Babyonyshev M | 1999 | Science1999，286，5440： | 1 |
| 7 | X-ray crystal structure of HLA-DR4 (DRA*0101,DRB1*0401) complexed with a peptide from human collagen Ⅱ显示文摘 | Dessen A Lawrence CM Cupo S | 1997 | Immunity1997，7，： | 1 |
| 8 | Halo eczema-resolution after excision of the central naevus alone显示文摘 | Cox NH Bloxham CA Lawrence CM | 1991 | Clin Exp Dermatol1991，16，1： | 1 |
| 9 | X-ray crystal structure of HLA-DR4 (DRA * 0101, DRB 1 * 0401 ) complexed with a peptide from human collagen Ⅱ显示文摘 | Dessen A Lawrence CM Cupo S | 1997 | Immunity1997，，： | 1 |
| 10 | Frequency of class I HLA-restricted anti-CD+8 T cells in individuals receiving highly active antiretroviral therapy(HAART)显示文摘 | Gray CM Lawrence J Schapiro JM | 1999 | J Immunol1999，162，3： | 1 |
| 11 | Formalin-fixed tissue Mohs surgery (slow Mohs) for basal cell carcinoma: 5-year follow-up data显示文摘 | Lawrence CM Haniffa M Dahl MG | 2009 | Br J Dermatol2009，160，3： | 1 |
| 12 | Improved visual function and attenuation of declines in health-related quality of life after cataract extraction显示文摘 | Mangione CM Phillips RS Lawrence MG | 1994 | Arch Ophthalmol1994，112，11： | 1 |
| 13 | ProMED-mail: An early warning system for emerging diseases 显示文摘 | Lawrence CM | 2004 | Surfing the Web2004，39，2： | 1 |
| 14 | Crystal structure of the ectodomain of human transferrin receptor显示文摘 | Lawrence CM Ray S Babyonyshev M | 1999 | Science1999，286，5440： | 1 |
| 15 | Wound complications following diagnostic skin biopsies in dermatology inpatients显示文摘 | Wahie S Lawrence CM | 2007 | Arch Dermatol2007，143，10： | 1 |
| 16 | The treatment of chondrodermatitis noduiaris with carti-lage removal alone 显示文摘 | Lawrence CM | 1991 | Arch Dermatol1991，127，4： | 1 |
| 17 | Treatment of myxoid cysts显示文摘 | De Berker DA Lawrence CM | 2001 | DermatolSurg2001，27，： | 1 |
| 18 | Measurement of involved surface area in patients with psoriasis显示文摘 | Ramsay B Lawrence CM | 1991 | Br J Dermatol1991，124，： | 1 |
| 19 | Utility of balanced steady- state free precession Mr venography in the diagnosis of lower extremity deep venous thrombosis 显示文摘 | Lindquist CM Karlicki F Lawrence P | 2010 | Am J Roentgenol2010，194，： | 1 |
| 20 | Selective sweat gland remo- val with minimal skin excision in the treatment of axillary hyperhidrosis: a retrospective clinical and histological review of 15 patients显示文摘 | Lawrence CM Lonsdale Eccles AA | 2006 | BrJ Dermatol2006，155，1： | 1 |
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