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| 1 | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease. | Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos | 2018 | World Journal of Gastroenterology2018，24，36： | 19 |
| 2 | Evidence based medicine and surgical approaches for colon cancer: Evidences, benefits and limitations of the laparoscopic vs open resection显示文摘AIM:To report a meta-analysis of the studies that compared the laparoscopic with the open approach for colon cancer resection.METHODS:Forty-seven manuscripts were reviewed,33 of which employed for meta-analysis according to the PRISMA guidelines.The results were differentiated according to the study design(prospective randomized trials vs case-control series)and according to the tu-mor’s location.Outcome measures included:(1)shortterm results(operating times,blood losses,bowel function recovery,post-operative pain,return to the oral intake,complications and hospital stay);(2)oncological adequateness(number of nodes harvested in the surgical specimens);and(3)long-term results(including the survivals’rates and incidence of incisional hernias)and(4)costs.RESULTS:Meta-analysis of trials provided evidences in support of the laparoscopic procedures for a several short-term outcomes including:a lower blood loss,an earlier recovery of the bowel function,an earlier return to the oral intake,a shorter hospital stay and a lower morbidity rate.Opposite the operating time has been confirmed shorter in open surgery.The same trend has been reported investigating case-control series and cancer by sites,even though there are some concerns regarding the power of the studies in this latter field due to the small number of trials and the small sample of patients enrolled.The two approaches were comparable regarding the mean number of nodes harvested and long-term results,even though these variables were documented reviewing the literature but were not computable for meta-analysis.The analysis of the costs documented lower costs for the open surgery,however just few studies investigated the incidence of postoperative hernias.CONCLUSION:Laparoscopy is superior for the majority of short-term results.Future studies should better differentiate these approaches on the basis of tumors’location and the post-operative hernias. | Laura Lorenzon Marco La Torre Vincenzo Ziparo Francesco Montebelli Paolo Mercantini Genoveffa Balducci Mario Ferri | 2014 | World Journal of Gastroenterology2014，20，13： | 8 |
| 3 | A scoping review on the field validation and implementation of rapid diagnostic tests for vector-borne and other infectious diseases of poverty in urban areas显示文摘Background:Health personnel face challenges in diagnosing vector-borne and other diseases of poverty in urban settings.There is a need to know what rapid diagnostic technologies are available,have been properly assessed,and are being implemented to improve control of these diseases in the urban context.This paper characterizes evidence on the field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of poverty.Main body:A scoping review was conducted.Peer-reviewed and grey literature were searched using terms describing the targeted infectious diseases,diagnostics evaluations,rapid tests,and urban setting.The review was limited to studies published between 2000 and 2016 in English,Spanish,French,and Portuguese.Inclusion and exclusion criteria were refined post hoc to identify relevant literature regardless of study design and geography.A total of 179 documents of the 7806 initially screened were included in the analysis.Malaria(n=100)and tuberculosis(n=47)accounted for the majority of studies that reported diagnostics performance,impact,and implementation outcomes.Fewer studies,assessing mainly performance,were identified for visceral leishmaniasis(n=9),filariasis and leptospirosis(each n=5),enteric fever and schistosomiasis(each n=3),dengue and leprosy(each n=2),and Chagas disease,human African trypanosomiasis,and cholera(each n=1).Reported sensitivity of rapid tests was variable depending on several factors.Overall,specificities were high(>80%),except for schistosomiasis and cholera.Impact and implementation outcomes,mainly acceptability and cost,followed by adoption,feasibility,and sustainability of rapid tests are being evaluated in the field.Challenges to implementing rapid tests range from cultural to technical and administrative issues.Conclusions:Rapid diagnostic tests for vector-borne and other diseases of poverty are being used in the urban context with demonstrated impact on case detection.However,most evidence comes from malaria rapid diagnostics,with variable results.While rapid tests for tuberculosis and visceral leishmaniasis require further implementation studies,more evidence on performance of current tests or development of new alternatives is needed for dengue,Chagas disease,filariasis,leptospirosis,enteric fever,human African trypanosomiasis,schistosomiasis and cholera. | Lyda Osorio Jonny Alejandro Garcia Luis Gabriel Parra Victor Garcia Laura Torres Stephanie Degroote Valery Ridde | 2018 | Infectious Diseases of Poverty2018，7，1： | 2 |
| 4 | Genetic diversity of the pln locus among oenological Lactobacillus plantarum strains显示文摘 | Yolanda Sáenz Beatriz Rojo-Bezares Laura Navarro Lorena Díez Sergio Somalo Myriam Zarazaga Fernanda Ruiz-Larrea Carmen Torres | 2009 | International Journal of Food Microbiology2009，，3： | 1 |
| 5 | Comparative study of the pln locus of the quorum-sensing regulated bacteriocin-producing L. plantarum J51 strain显示文摘 | Laura Navarro Beatriz Rojo-Bezares Yolanda Sáenz Lorena Díez Myriam Zarazaga Fernanda Ruiz-Larrea Carmen Torres | 2008 | International Journal of Food Microbiology2008，，2： | 1 |
| 6 | Utility of Stool Sample–based Tests for the Diagnosis of Helicobacter pylori Infection in Children显示文摘 | Yelda A Leal Roberto Cedillo-Rivera J Abraham Simón Juan R Velázquez Laura L Flores Javier Torres | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，6： | 1 |
| 7 | The expression of epidermal growth factor receptor results in a worse prognosis for patients with rectal cancer treated with preoperative radiotherapy: a multicenter, retrospective analysis显示文摘 | Jordi Giralt Manuel de las Heras Laura Cerezo Aranzazu Eraso Edurado Hermosilla Dolores Velez Juan Lujan Eloi Espin Jose Rossello Joaquin Majó Sergi Benavente Manel Armengol I. de Torres | 2005 | Radiotherapy and Oncology2005，，2： | 1 |
| 8 | Early management of type 2 diabetes based on a SMBG strategy: the way to diabetes regression—the St Carlos study显示文摘 | Nuria García de la Torre Alejandra Durán Laura Valle Manuel Fuentes Idoya Barca Patricia Martín Carmen Monta?ez Natalia Perez-Ferre Rosario Abad Fuencisla Sanz Mercedes Galindo Miguel A. Rubio Alfonso L. Calle-Pascual | 2013 | Acta Diabetologica2013，，4： | 1 |
| 9 | Number of harvested lymph nodes is the main prognostic factor in Stage IIa colorectal cancer patients显示文摘 | Marco La Torre Laura Lorenzon Emanuela Pilozzi Viola Barucca Marco Cavallini Vincenzo Ziparo Mario Ferri | 2012 | J Surg Oncol2012，，4： | 1 |
| 10 | Escherichia coli of poultry food origin as reservoir of sulphonamide resistance genes and integrons显示文摘 | Leila Soufi Yolanda Sáenz Laura Vinué Mohamed Salah Abbassi Elena Ruiz Myriam Zarazaga Assia Ben Hassen Salah Hammami Carmen Torres | 2010 | International Journal of Food Microbiology2010，，： | 1 |
| 11 | Fungal peritonitis in a large chronic peritoneal dialysis population: a report of 55 episodes显示文摘 | Sue J. Goldie Laura Kiernan-Troidle Carlos Torres Nancy Gorban-Brennan Dana Dunne Alan S. Kliger Frederic O. Finkelstein | 1996 | American Journal of Kidney Diseases1996，，1： | 1 |
| 12 | Interactive effects of n -TiO 2 and 2,3,7,8-TCDD on the marine bivalve Mytilus galloprovincialis显示文摘 | Laura Canesi Giada Frenzilli Teresa Balbi Margherita Bernardeschi Caterina Ciacci Simonetta Corsolini Camilla Della Torre Rita Fabbri Claudia Faleri Silvano Focardi Patrizia Guidi Anton Ko?an Antonio Marcomini Michela Mariottini Marco Nigro Karla Pozo-Gal | 2013 | Aquatic Toxicology2013，，： | 1 |
| 13 | Role of gemcitabine in metastatic breast cancer patients: A short review显示文摘 | Nicola Silvestris Saverio Cinieri Ignazia La Torre Giuseppe Pezzella Gianmauro Numico Laura Orlando Vito Lorusso | 2007 | The Breast2007，，3： | 1 |
| 14 | Vascular and Psychosocial Factors in Alzheimer’s Disease:Epidemiological Evidence Toward Intervention显示文摘 | Jack C. de la Torre Chengxuan Qiu Weili Xu Laura Fratiglioni | 2010 | Journal of Alzheimer’s Disease2010，，： | 1 |
| 15 | Efficacy of linezolid compared to vancomycin in an experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated pigs*显示文摘 | Pilar Martinez-Olondris Montserrat Rigol Dolors Soy Laura Guerrero Carlos Agusti Maria Angels Quera Gianluigi Li Bassi Mariano Esperatti Nestor Luque Manto Liapikou Xavier Filella Francesc Marco Jordi Puig de la Bellacasa Antoni Torres | 2012 | Critical Care Medicine2012，，1： | 1 |
| 16 | Rheological and hydration characterization of calcium sulfoaluminate cement pastes显示文摘 | Marta García-Maté Isabel Santacruz ángeles G. De la Torre Laura León-Reina Miguel A.G. Aranda | 2012 | Cement and Concrete Composites2012，，5： | 1 |
| 17 | Coculture-inducible bacteriocin activity of Lactobacillus plantarum strain J23 isolated from grape must显示文摘 | Beatriz Rojo-Bezares Yolanda Sáenz Laura Navarro Myriam Zarazaga Fernanda Ruiz-Larrea Carmen Torres | 2006 | Food Microbiology2006，，5： | 1 |
| 18 | The Role of the Solar Cycle in the Relationship Between the North Atlantic Oscillation and Northern Hemisphere Surface Temperatures显示文摘北方大西洋摆动(NAO ) 是在北半球的气候可变性的领先的模式之一。它清楚地在气象学的变量联系到变化,这被显示出,例如地面温度,在半球的规模。然而,最近的研究表明了 NAO 空间模式也取决于太阳的强迫。因此,它气象学的变量上的效果必须变化取决于这个因素。而且,它能是阳光通过可变性模式影响气候,是这研究的焦点的一个假设。我们发现在 NAO/AO 和半球的温度之间的关系变化取决于太阳活动。结果看积极重要关联太阳活动是否仅仅高。另外,结果支持那项太阳活动影响对流的想法在经由同温层的极的旋涡的变化的北半球的球的气候变化。 | Laura DE LA TORRE Luis GIMENO Juan Antonio AEL Raquel NIETO | 2007 | Advances in Atmospheric Sciences2007，24，2： | 0 |
| 19 | Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of Cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday显示文摘Following a large-scale phylogenetic study of the lichenized genus Cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 years.Based on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been sequenced.Species of Cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is provided.The new species are:Cora accipiter Moncada,Madrin˜a´n&Lücking spec.nov.,C.applanata Moncada,Soto-Medina&Lücking spec.nov.,C.arachnodavidea Moncada,Dal Forno&Lücking spec.nov.,C.arborescens Dal Forno,Chaves&Lücking spec.nov.,C.arcabucana Moncada,C.Rodrı´guez&Lücking spec.nov.,C.aturucoa Lücking,Moncada&C.Vargas spec.nov.,C.auriculeslia Moncada,Ya´nez-Ayabaca&Lücking spec.nov.,C.barbifera Moncada,Patin˜o&Lücking spec.nov.,C.boleslia Lücking,E.Morales&Dal Forno spec.nov.,C.caliginosa Holgado,Rivas Plata&Perlmutter spec.nov.,C.campestris Dal Forno,Eliasaro&Spielmann spec.nov.,C.canari Nugra,Dal Forno&Lücking spec.nov.,C.caraana Lücking,Martins&Lucheta spec.nov.,C.casasolana Moncada,R.-E.Pe´rez&Lücking spec.nov.,C.caucensis Moncada,M.Gut.&Lücking spec.nov.,C.celestinoa Moncada,CabreraAmaya&Lücking spec.nov.,C.comaltepeca Moncada,R.-E.Pe´rez&Herrera-Camp.spec.nov.,C.corani Lücking,E.Morales&Dal Forno spec.nov.,C.corelleslia Moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.crispoleslia Moncada,J.Molina&Lücking spec.nov.,C.cuzcoensis Holgado,Rivas Plata&Perlmutter spec.nov.,C.dalehana Moncada,Madrin˜a´n&Lücking spec.nov.,C.davibogotana Lücking,Moncada&Coca spec.nov.,C.davicrinita Moncada,Madrin˜a´n&Lücking spec.nov.,C.davidia Moncada,L.Vargas&Lücking spec.nov.,C.dewisanti Moncada,A.Sua´rez-Corredor&Lücking spec.nov.,C.dulcis Moncada,R.-E.Pe´rez&Lücking spec.nov.,C.elephas Lücking,Moncada&L.Vargas spec.nov.,C.fuscodavidiana Lücking,Moncada&L.Vargas spec.nov.,C.garagoa Simijaca,Moncada&Lücking spec.nov.,C.gigantea Lücking,Moncada&Coca spec.nov.,C.gomeziana Dal Forno,Chaves&Lücking spec.nov.,C.guajalitensis Lücking,Robayo&Dal Forno spec.nov.,C.hafecesweorthensis Moncada,Lücking&R.Pela´ez spec.nov.,C.haledana Dal Forno,Chaves&Lücking spec.nov.,C.hawksworthiana Dal Forno,P.Nelson&Lücking spec.nov.,C.hochesuordensis Lücking,E.Morales&Dal Forno spec.nov.,C.hymenocarpa Lücking,Chaves&Lawrey spec.nov.,C.imi Lücking,Chaves&Lawrey spec.nov.,C.itabaiana Dal Forno,Aptroot&M.Ca´ceres spec.nov.,C.leslactuca nov.,C.maxima Wilk,Dal Forno&Lücking spec.nov.,C.minutula Lücking,Moncada&Ya´nez-Ayabaca spec.nov.,C.palaeotropica Weerakoon,Aptroot&Lücking spec.nov.,C.palustris Dal Forno,Chaves&Lücking spec.nov.,C.parabovei Dal Forno,Kukwa&Lücking spec.nov.,C.paraciferrii Lücking,Moncada&J.E.Hern.spec.nov.,C.paraminor Dal Forno,Chaves&Lücking spec.nov.,C.pastorum Moncada,Patin˜o&Lücking spec.nov.,C.pichinchensis Paredes,Jonitz&Dal Forno spec.nov.,C.pikynasa J.-M.Torres,Moncada&Lücking spec.nov.,C.pseudobovei Wilk,Dal Forno&Lücking spec.nov.,C.pseudocorani Lücking,E.Morales&Dal Forno spec.nov.,C.putumayensis L.J.Arias,Moncada&Lücking spec.nov.,C.quillacinga Moncada,F.Ortega&Lücking spec.nov.,C.rothesiorum Moncada,Madrin˜a´n&Lücking spec.nov.,C.rubrosanguinea Nugra,Moncada&Lücking spec.nov.,C.santacruzensis Dal Forno,Bungartz&Ya´nezAyabaca,spec.nov.,C.schizophylloides Moncada,C.Rodrı´guez&Lücking spec.nov.,C.smaragdina Lücking,Rivas Plata&Chaves spec.nov.,C.soredavidia Dal Forno,Marcelli&Lücking spec.nov.,C.subdavicrinita Moncada,J.Molina&Lücking spec.nov.,C.suturifera Nugra,Besal&Lücking spec.nov.,C.terrestris Dal Forno,Chaves&Lücking spec.nov.,C.terricoleslia Wilk,Dal Forno&Lücking spec.nov.,C.udebeceana Moncada,R.Pela´ez&Lücking,Moncada&R.Pela´ez spec.Lücking spec.nov.,C.urceolata Moncada,Coca&Lücking spec.nov.,C.verjonensis Lücking,Moncada&Dal Forno spec.nov.,C.viliewoa Lücking,Chaves&Soto-Medina spec.nov.,and C.yukiboa Mercado-Dı´az,Moncada&Lücking spec.nov.Furthermore,the taxonomic status of the recently described or recognized species C.arachnoidea,C.aspera,C.ciferrii,and C.reticulifera,is revised. | Robert Lücking Manuela Dal Forno Bibiana Moncada Luis Fernando Coca Leidy Yasmín Vargas-Mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego Mauricio Cabrera-Amaya Marcela E.S.Cáceres José Luis Chaves Sionara Eliasaro Martha Cecilia Gutiérrez Jesús E.Hernández Marin María de los Ángeles Herrera-Campos María E.Holgado-Rojas Harald Jonitz Martin Kukwa Fabiane Lucheta Santiago Madriñán Marcelo Pinto Marcelli Suzana Maria de Azevedo Martins Joel A.Mercado-Díaz Jorge Alberto Molina Eduardo A.Morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata Javier Robayo Camilo Rodríguez Diego Fernando Simijaca Edier Soto-Medina Adriano Afonso Spielmann Alejandra Suárez-Corredor Jean-Marc Torres Carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk Marcela Celis Pacheco Mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick M.Gillevet Masoumeh Sikaroodi James D.Lawrey | 2017 | Fungal Diversity2017，，3： | 0 |
| 20 | Current strategies to diagnose and manage positive surgical margins and local recurrence after partial nephrectomy显示文摘Objective:No standard strategy for diagnosis and management of positive surgical margin(PSM)and local recurrence after partial nephrectomy(PN)are reported in literature.This review aims to provide an overview of the current strategies and further perspectives on this patient setting.Methods:A non-systematic review of the literature was completed.The research included the most updated articles(about the last 10 years).Results:Techniques for diagnosing PSMs during PN include intraoperative frozen section,imprinting cytology,and other specific tools.No clear evidence is reported about these methods.Regarding PSM management,active surveillance with a combination of imaging and laboratory evaluation is the first option line followed by surgery.Regarding local recurrence management,surgery is the primary curative approach when possible but it may be technically difficult due to anatomy resultant from previous PN.In this scenario,thermal ablation(TA)may have the potential to circumvent these limitations representing a less invasive alternative.Salvage surgery represents a valid option;six studies analyzed the outcomes of nephrectomy on local recurrence after PN with three of these focused on robotic approach.Overall,complication rates of salvage surgery are higher compared to TA but ablation presents a higher recurrence rate up to 25%of cases that can often be managed with repeat ablation.Conclusion:Controversy still exists surrounding the best strategy for management and diagnosis of patients with PSMs or local recurrence after PN.Active surveillance is likely to be the optimal first-line management option for most patients with PSMs.Ablation and salvage surgery both represent valid options in patients with local recurrence after PN.Conversely,salvage PN and radical nephrectomy have fewer recurrences but are associated with a higher complication rate compared to TA.In this scenario,robotic surgery plays an important role in improving salvage PN and radical nephrectomy outcomes. | Umberto Carbonara Daniele Amparore Cosimo Gentile Riccardo Bertolo Selcuk Erdem Alexandre Ingels Michele Marchioni Constantijn H.J.Muselaers Onder Kara Laura Marandino Nicola Pavan Eduard Roussel Angela Pecoraro Fabio Crocerossa Giuseppe Torre Riccardo Campi Pasquale Ditonno | 2022 | Asian Journal of Urology2022，9，3： | 0 |
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