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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | JUPITER-02 trial: advancing survival for recurrent metastatic nasopharyngeal carcinoma and next steps显示文摘Nasopharyngeal carcinoma(NPC)is a disease with unique epidemiology.It is endemic in Southern China,Southeast Asia,and North Africa,and typically affects males more than females in the 30-60 years age group[1].Globally,133,354 NPC cases were diagnosed in 2020 with 80,008;deaths in the same year[2].While the survival rates of early-stage NPC after radiotherapy(RT)are high,dis-ease recurrences are common in locoregionally-advanced NPC,with the predominant pattern of failure being dis-tant metastasis[3].In this clinical scenario,palliative chemotherapy is the primary treatment modality。 | Laura Ling Ying Tan Quynh-Thu Le Nancy Ying Ying Lee Melvin Lee Kiang Chua | 2022 | Cancer Communications2022，42，1： | 2 |
| 3 | Genome-wide Association and Follow-Up Replication Studies Identified ADAMTS18 and TGFBR3 as Bone Mass Candidate Genes in Different Ethnic Groups显示文摘 | Dong-Hai Xiong Xiao-Gang Liu Yan-Fang Guo Li-Jun Tan Liang Wang Bao-Yong Sha Zi-Hui Tang Feng Pan Tie-Lin Yang Xiang-Ding Chen Shu-Feng Lei Laura M. Yerges Xue-Zen Zhu Victor W. Wheeler Alan L. Patrick ClareAnn H. Bunker Yan Guo Han Yan Yu-Fang Pei Yin-Pi | 2009 | The American Journal of Human Genetics2009，，3： | 1 |
| 4 | Cytokine induced production of monocyte chemoattractant protein-1 by cultured human mesangial cells显示文摘 | Teizo Yoshiumura Laura Tan | 1992 | J Immunol1992，148，： | 1 |
| 5 | Comprehensive Desmosome Mutation Analysis in North Americans With Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy显示文摘 | A Dénise den Haan Boon Yew Tan Michelle N. Zikusoka Laura Iba?ez Lladó Rahul Jain Amy Daly Crystal Tichnell Cynthia James Nuria Amat-Alarcon Theodore Abraham Stuart D. Russell David A. Bluemke Hugh Calkins Darshan Dalal Daniel P. Judge | 2009 | Circulation: Cardiovascular Genetics2009，，5： | 1 |
| 6 | Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer显示文摘 | Klarisa Rikova Ailan Guo Qingfu Zeng Anthony Possemato Jian Yu Herbert Haack Julie Nardone Kimberly Lee Cynthia Reeves Yu Li Yerong Hu Zhiping Tan Matthew Stokes Laura Sullivan Jeffrey Mitchell Randy Wetzel Joan MacNeill Jian Min Ren Jin Yuan Corey E. Bak | 2007 | Cell2007，，6： | 1 |
| 7 | The accuracy of sentinel lymph node biopsy in multicentric and multifocal invasive breast cancers显示文摘 | Eleni Tousimis Kimberly J Van Zee Jane V Fey Laura Weldon Hoque Lee K Tan Hiram S Cody Patrick I Borgen Leslie L Montgomery | 2003 | Journal of the American College of Surgeons2003，，4： | 1 |
| 8 | Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review显示文摘 | Joaquín J. García Laura López‐Pingarrón Priscilla Almeida‐Souza Alejandro Tres Pilar Escudero Francisco A. García‐Gil Dun‐Xian Tan Russel J. Reiter Jose M. Ramírez Milagros Bernal‐Pérez | 2014 | J Pineal Res2014，，3： | 1 |
| 9 | Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review显示文摘 | Joaquín J. García Laura López‐Pingarrón Priscilla Almeida‐Souza Alejandro Tres Pilar Escudero Francisco A. García‐Gil Dun‐Xian Tan Russel J. Reiter Jose M. Ramírez Milagros Bernal‐Pérez | 2014 | J. Pineal Res2014，，3： | 1 |
| 10 | Improved light trapping in microcrystalline silicon solar cells by plasmonic back reflector with broad angular scattering and low parasitic absorption显示文摘 | TAN H R LAURA S YAN B J | 2013 | Appl Phys Lett2013，102，15： | 1 |
| 11 | Extract of Curcuma Ionga L. and (-)-Epigallo Catechin-3-Gallate Enhanced Proliferation of Adipose Tissue-derived Mesenchymal Stem Cells (AD-MSCs) and Differentiation of AD-MSCs into Endothelial Progenitor Cells显示文摘 | Wahyu Widowati Caroline Tan Sardjono Laura Wij aya Dian Ratih Laksmitawati Ferry Sandra | 2012 | Journal of US-China Medical Science2012，9，1： | 0 |
| 12 | 深圳证券交易所显示文摘股票市场的本质是投机买卖:基于资本,而非物质。深圳证券交易所可被设想为虚拟股票市场的具体实践:这一栋拥有悬浮基座的建筑物不但能发挥物理功能,为股票市场提供场地,更重要的是它象征了股票市场。一般来说,基座用以锚固结构,并将其牢牢地与地面连接;然而,深圳证券交易所的基座却沿着塔楼从地面往高处攀升, | Kunle Adeyemi Ryann Aoukar Sebastian Appl Laura Baird Waichuen Chan Jan Dechow Lukas Drasnar Matthew Engele Leo Ferretto Clarisa Garcia Fresco Alasdair Graham Jaitian Gu Matthew Haseltine Joo Ferreira Marques Jesus Matthew Jull Alexde Jong Santiago Hierro Kennedy Klaas Kresse Miranda Lee Anna Little Luxiang Liu David Eugin Moon Cristina Murphy Se Yoon Park Ferdjan Vander Pijl Franscesca Portesine Idrees Rasouli Korbinian Schneider Wolfgang Schwarzwalder Felix Schwimmer Richard Sharam Lukasz Skalec Christine Svensson Lukasz Szlachcic Ken Yang Tan Michela Tonus Miroslav Vavrina Na Wei Xinyuan Wang Leonie Wenz Su Xia Yunchao Xu Yang Yang Yun Zhang | 2014 | 城市环境设计2014，，6： | 0 |
| 13 | Forecasting the number of species of asexually reproducing fungi(Ascomycota and Basidiomycota)显示文摘Asexually reproducing fungi play a significant role in essential processes in managed and wild ecosystems such as nutrients cycling and multitrophic interactions.A large number of such taxa are among the most notorious plant and animal pathogens.In addition,they have a key role in food production,biotechnology and medicine.Taxa without or rare sexual reproduction are distinguished based on their sporulating structures and conidiomata in traditional morphology-based taxonomy.The number,variation and diversity of asexually reproducing taxa are insufficiently known,even though fungi capable of asexual reproduction may provide an untapped,rich biological resource for future exploitation.Currently,ca.30,000 asexual species belonging to ca.3800 genera have been reported(including 1388 coelomycetous and 2265 hyphomycetous genera).Recent reports(2017–2020)reiterate that the number of asexually producing fungi is higher than the number of frequently sexually-reproducing fungi.With the advent of molecular tools and the abandonment of the dual nomenclature system for pleomorphic fungi,priority criteria were established and revisited in the latest outline of fungi and fungus-like taxa.However,species numbers and taxonomic boundaries of pleomorphic taxa and their synanamorphs or synasexual morphs have yet to be addressed.The number of species of speciose genera(e.g.Alternaria,Aspergillus,Cercospora,Fusarium,Phoma and Pseudocercospora),cryptic species,species of pleomorphic genera,less studied life modes(such as lichenicolous taxa,taxa from extreme environments)and species from biodiversity-rich areas still need evaluation to achieve more reliable estimates of their diversity.This paper discusses the current knowledge on the matter,with diversity estimates,and potential obstacles in several chapters on(1)speciose genera;(2)pleomorphic genera;(3)cryptic species;(4)well-studied but insufficiently resolved taxa,e.g.leaf inhabiting species,marine fungi,(5)less studied life modes,e.g.lichenicolous,rock-inhabiting fungi,insect-associated and yeast-forming taxa and(6)species from biodiversity-rich areas. | Nalin N.Wijayawardene Alan J.L.Phillips Diana Santos Pereira Dong-Qin Dai AndréAptroot Josiane S.Monteiro Irina S.Druzhinina Feng Cai Xinlei Fan Laura Selbmann Claudia Coleine Rafael F.Castañeda-Ruiz Martin Kukwa Adam Flakus Patricia Oliveira Fiuza Paul M.Kirk Kunhiraman C.Rajesh Kumar Ilesha S.leperuma Arachchi Nakarin Suwannarach Li-Zhou Tang Teun Boekhout Chen Shuhui Tan R.P.Prabath K.Jayasinghe Marco Thines | 2022 | Fungal Diversity2022，，3： | 0 |
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